Ponder and the San Francisco 49ers quarterback got married in Dec. 2012 and already share daughter Bowden "Scout" Sainte-Claire, 2. She announced that they were expecting a second child late last year and revealed that she's due this spring.
The 31-year-old "College GameDay" host took a stand against her haters amid divisive rumors that she could replace Chris Berman on "Sunday NFL Countdown." Fans of Berman, who left the show in January, were vocal on Twitter about their disapproval of the potential replacement.
This wouldn't be the first time Ponder has replaced a highly-regarded ESPN personality. She took over on "College GameDay" from Erin Andrews back in 2012.
See photos of Samantha Ponder:
ESPN's Samantha Ponder out and about
ESPN's Samantha Ponder out and about
ATLANTA, GA - DECEMBER 31: ESPN sideline reporter Sam Ponder talks during the Chick-fil-A Bowl game between the Texas A&M Aggies and the Duke Blue Devils at the Georgia Dome on December 31, 2013 in Atlanta, Georgia. (Photo by Mike Zarrilli/Getty Images)
TALLAHASSEE, FL - OCTOBER 29: ESPN field reported Sam Ponder during an NCAA football game between the Florida State Seminoles and the Clemson Tigers on October 29, 2016, at Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, FL. (Photo by Logan Stanford/Icon Sportswire via Getty Images)
TALLAHASSEE, FL - OCTOBER 29: Clemson quarterback Deshaun Watson (4) in a postgame interview with Sam Ponder after an NCAA football game between the Florida State Seminoles and the Clemson Tigers on October 29, 2016, at Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, FL. Clemson defeated Florida State 37-34. (Photo by Logan Stanford/Icon Sportswire via Getty Images)
JIMMY KIMMEL LIVE - 'Jimmy Kimmel Live' airs every weeknight at 11:35 p.m. EST and features a diverse lineup of guests that include celebrities, athletes, musical acts, comedians and human interest subjects, along with comedy bits and a house band. The guests for Tuesday, December 13 included Rami Malek ('Mr. Robot'), Sportscaster Samantha Ponder (College Football Playoff on ESPN), musical guest Gucci Mane featuring Travis Scott and Aubrey Logan sitting in with Cleto and the Cletones. (Randy Holmes/ABC via Getty Images)
NASHVILLE, TN - NOVEMBER 02: Kirk Herbstreit and Samantha Ponder speak onstage at the 50th annual CMA Awards at the Bridgestone Arena on November 2, 2016 in Nashville, Tennessee. (Photo by Erika Goldring/FilmMagic)
BATTLEBOTS - 'Gr8 Expectations: The Quarterfinals' - The robot carnage continues as competitors put their minds and metal to the test on part one of the season finale of 'BattleBots,' THURSDAY, SEPTEMBER 1 (8:00-9:00 p.m. EDT), on the ABC Television Network. The next-generation robots will go head to head in the Quarterfinals, as eight teams fight their way to the championship in hopes of scoring the ultimate prize, the Giant Nut. (Adam Taylor/ABC via Getty Images)
PHOENIX, AZ - JANUARY 09: Samantha Ponder and Christian Ponder attend the Allstate party at the Playoff Blue Carpet on January 9, 2016 in Phoenix, Arizona. (Photo by Mike Moore/Getty Images for ESPN)
12 January 2015: ESPN's Rece Davis and Samantha Ponder during the Ohio State Buckeyes game versus the Oregon Ducks in the College Football Playoff National Championship at AT&T Stadium in Arlington, TX. Ohio State won 42-20. (Photo by Ray Carlin/Icon Sportswire/Corbis via Getty Images)
THE VIEW - Stacy London and Samantha Ponder guest co-host Thursday, February 26, 2015. Guests include ABC News' Diane Sawyer; Teri Polo, Sherri Saum, Maia Mitchell (ABC Family's 'The Fosters'); Vine week on 'The View' featuring self-proclaimed digital magician Zach King from Portland, Oregon. 'The View' airs Monday-Friday (11:00 am-12:00 pm, ET) on the ABC Television Network.
(Photo by Lou Rocco/ABC via Getty Images)
10 January 2015: ESPN reporter Samantha Ponder during the College Football Playoff National Championship media day held at the Dallas Convention Center in Dallas, Texas. (Photo by Matthew Visinsky/Icon Sportswire/Corbis via Getty Images)
LOUISVILLE, KY - SEPTEMBER 1: ESPN college football reporter Samantha Steele Ponder is seen during the game between the Miami Hurricanes and the Louisville Cardinals at Papa John's Cardinal Stadium on September 1, 2014 in Louisville, Kentucky. (Photo by Joe Robbins/Getty Images)
ATLANTA, GA - SEPTEMBER 26: ESPN reporter Samantha Ponder interviews head coach Frank Beamer and Logan Thomas #3 of the Virginia Tech Hokies after their 17-10 win over the Georgia Tech Yellow Jackets at Bobby Dodd Stadium on September 26, 2013 in Atlanta, Georgia. (Photo by Kevin C. Cox/Getty Images)
NEW YORK, NY - APRIL 25: Sportscaster Samantha Ponder poses for a picture as Sportiqe and ESPN host a NBA Playoff Party at Bloomingdale's 59th Street Store on April 25, 2013 in New York City. (Photo by Mike Coppola/Getty Images for Sportique)
HOLLYWOOD, CA - JULY 16: Professional basketball player Christian Ponder (L) and ESPN Sportscaster Samantha Ponder attend ESPN The Magazine 5th annual 'Body Issue' party at Lure on July 16, 2013 in Hollywood, California. (Photo by Michael Kovac/WireImage)
CHAPEL HILL, NC - MARCH 09: Seth Curry #30 of the Duke Blue Devils speaks with Samantha Steele Ponder of ESPN after a game against the North Carolina Tar Heels on March 09, 2013 at the Dean E. Smith Center in Chapel Hill, North Carolina. Duke won 69-53. (Photo by Peyton Williams/UNC/Getty Images)
ANN ARBOR, MI - FEBRUARY 5: Michigan Wolverines fans pose for a photo with ESPN sideline reporter Samantha Ponder before the game against the Ohio State Buckeyes at Crisler Center on February 5, 2013 in Ann Arbor, Michigan. Michigan won the game 76-74 in overtime. (Photo by Joe Robbins/Getty Images)
NEW ORLEANS, LA - FEBRUARY 02: (L-R) Quarterback Christian Ponder of the Minnesota Vikings, ESPN sportscaster Samantha Steele and Offensive Rookie of the Year Robert Griffin aka RG3 of the Washington Redskins attend CAA Sports Super Bowl Party presented By LG at Contemporary Arts Center on February 2, 2013 in New Orleans, Louisiana. (Photo by Kevin Mazur/WireImage)
NEW ORLEANS, LA - FEBRUARY 01: Samantha Steele and NFL player Christian Ponder attend ESPN The Magazine's 'NEXT' Event at Tad Gormley Stadium on February 1, 2013 in New Orleans, Louisiana. (Photo by Robin Marchant/Getty Images for ESPN)
ORLANDO, FL - JANUARY 1: Samantha Ponder gets set to do postgame interviews after the Capital One Bowl between the Georgia Bulldogs and the Nebraska Cornhuskers at the Citrus Bowl on January 1, 2013 in Orlando, Florida. (Photo by Scott Cunningham/Getty Images)