Throughout his storied career, which earned him four Grammys, Scruggs worked with the likes of Waylon Jennings, Alison Krauss, Toby Keith, Dolly Parton and Dixie Chicks, among many others.
Scruggs was born in Nashville in 1953 and was the second of three songs born to Earl and Louise Scruggs.
See photos of Randy Scruggs:
Randy Scruggs throughout his career
Randy Scruggs throughout his career
Randy Scruggs at the BMI Country Awards at the BMI Nashville building in Nashville, Tennessee. 11/5/02. Photo by Scott Gries/Getty Images
(Original Caption) Vince Gill and Randy Scruggs with their award for 'A Soldier's Joy'. (Photo by Frank Trapper/Corbis via Getty Images)
LOS ANGELES, CA - FEBRUARY 23: (L-R) Randy Scruggs, Deana Carter and Steve Wariner attend Orville H. Gibson Guitar Awards on February 23, 1999 at the Hard Rock Cafe in Los Angeles, California. (Photo by Ron Galella, Ltd./WireImage)
Randy Scruggs, Kris Kristofferson, Heidi Newfield and guest (Photo by Frank Mullen/WireImage)
NASHVILLE, TN - NOVEMBER 5: Randy Scruggs, winner of the 'Musician of the Year Award,' poses backstage at the '37th Annual CMA Awards' at the Grand Ole Opry House November 5, 2003 in Nashville, Tennessee. (Photo by Rusty Russell/Getty Images)
Randy Scruggs during the 2 hour special that premieres Saturday November 15th at 8pm EST/PST on CMT (Photo by R. Diamond/WireImage)
Earl Scruggs and Randy Scruggs during EMI Post-GRAMMY Party - Arrivals at Beverly Hill Hotel in Beverly Hills, California, United States. (Photo by Victor Spinelli/WireImage)
NASHVILLE, TN - NOVEMBER 7: Honoree Earl Scruggs (C), flanked by sons Gary (L) and Randy (R) pose at the 2005 Nashville Chapter Recording Academy Honors November 7, 2005 in Nashville, Tennessee. (Photo by Kathleen Barry/Getty Images)
Randy Scruggs, Earl Scruggs and Gary Scruggs during The Recording Academy HONORS - Nashville Chapter at Loews Vanderbilt Plaza Hotel in Nashville, Tennessee, United States. (Photo by Rick Diamond/WireImage)
Randy Scruggs and Dwight Yoakam during 2006 CMT Music Awards - Backstage and Audience at Curb Event Center at Belmont University in Nashville, Tennessee, United States. (Photo by Rick Diamond/WireImage)
Randy Scruggs at the Gaylord Entertainment Center in Nashville, Tennessee (Photo by Stephen Lovekin/WireImage)
Musician Randy Scruggs arrives at the BMI Country Awards and reception honoring Willie Nelson at the BMI building on November 6, 2007 in Nashville, Tennessee. (Photo by Rick Diamond/WireImage)
LOS ANGELES, CA - FEBRUARY 09: Randy Scruggs, Earl Scruggs and Congressperson Howard Coble N.C. after Earl Scruggs accepts The Lifetime Achievement Award presented by Recording Academy President and CEO, Neil Portnow at The 50th Annual Grammy Awards, Special Merit Awards Cermony held at The Wilshire - Ebell Theater in Los Angeles California on February 9, 2008 (Photo by Rick Diamond/WireImage)
NASHVILLE, TN - FEBRUARY 26: Glenn Worf, Singer/Songwriter Marinda Lambert and Musician Randy Scruggs at the BMI Honors Miranda Lambert's for her First #1single with a 1940's style bash and a few hundred of her friends at The Cellar on February 26, 2010 in Nashville, Tennessee. (Photo by Rick Diamond/Getty Images for BMI)
NASHVILLE, TN - SEPTEMBER 20: Musician Randy Scruggs attends the 4th Annual ACM Honors at the Ryman Auditorium on September 20, 2010 in Nashville, Tennessee. (Photo by Rick Diamond/Getty Images for ACM)
NASHVILLE, TN - SEPTEMBER 20: Top Specialty Instrument Player of the Year Randy Scruggs performs during the 4th Annual ACM Honors at the Ryman Auditorium on September 20, 2010 in Nashville, Tennessee. (Photo by Frederick Breedon/Getty Images for ACM)
NASHVILLE, TN - SEPTEMBER 20: Randy Scruggs attends the 4th Annual ACM Honors on September 20, 2010 in Nashville, Tennessee. (Photo by Frederick Breedon/WireImage)
NASHVILLE, TN - NOVEMBER 04: Music producer Randy Scruggs and singer-songwriter Keith Urban attend the BMI 2014 Country Awards at BMI on November 4, 2014 in Nashville, Tennessee. (Photo by Rick Diamond/Getty Images for BMI)
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"It had to have been incredibly hard to grow up as the son of Earl Scruggs," said WSM DJ and Grand Ole Opry announcer Eddie Stubbs, USA Today reports. "But Randy in his own way carved a very successful path out for himself in a multifaceted career. I know that his parents were both very proud of him and his brothers Gary and Steve. If you were to get into Earl Scruggs’ car and see what he had musically at his fingertips, it was generally a CD by the original Carter Family, something by Uncle Dave Macon and the latest project that Randy was involved in."
Scruggs performed as part of a duo with his brother, Gary, as well as with his father and brothers in the Earl Scruggs Revue for more than a decade. He went on to release a solo album, Crown of Jewels, in 1998. The album featured collaborations with the likes of Trisha Yearwood and Vince Gill.
Randy Scruggs is survived by wife Sandy, daughter Lindsey and brother Gary, the Tennessean reports.