The coronavirus is straining the global health care system, with one piece of lifesaving medical equipment in particularly scarce supply: mechanical ventilators.
A ventilator helps patients who cannot properly breathe on their own by pumping air into their lungs through a tube that has been surgically inserted into their windpipes. Because COVID-19, the disease caused by the coronavirus, affects the respiratory system, the number of hospitalized patients in need of breathing assistance has exploded since the pandemic began.
Most hospitals in the United States had enough ventilators to serve their patients prior to the pandemic, said Dr. Albert Rizzo, chief medical officer at the American Lung Association. But now, many are fearing they will run out — and soon.
"This is a disease that people are dying of because of respiratory illness. They're not dying because their heart fails, they're not dying of shock," Rizzo said. "They're dying because they just can't get oxygen to their bloodstream, and that makes other organs fail, as well."
"This is a disease that people are dying of because of respiratory illness. They're not dying because their heart fails, they're not dying of shock."
The vast majority of those infected by the coronavirus do not need hospitalization, with a report last month finding that 80 percent of people who got the coronavirus in China had mild symptoms that could be treated at home. Of the 20 percent who required hospitalization, 13.8 percent had severe disease, including respiratory problems, and 6.1 percent had critical illness, including respiratory failure.
The statistics may seem small, but because the coronavirus has infected so many people — nearly half a million people worldwide so far — hospitals are overtaxed.
"With the high proportion of the people who are getting the disease to begin with, and we know that a substantial fraction of them will go on to develop critical illness necessitating a mechanical ventilator, that’s the reason we are at a vulnerability to run out of ventilators as a critical resource," said Dr. Benjamin Singer, assistant professor of medicine in pulmonary and critical care at Northwestern University Feinberg School of Medicine.
What is a ventilator and who needs one?
Ventilators are hospital bedside machines that assist with two critical functions: getting enough oxygen into the bloodstream and clearing carbon dioxide out, which can build up when the patient is too weak or sick to move air in and out of the lungs. The decision to hook a patient up to one is made when it is clear that their lungs have become too inflamed or injured to do those functions on their own, and when steps that are less invasive, like an oxygen mask placed over a person's nose and mouth, fails to deliver what the patient needs.
"Through different types of settings, we're able to sync up with how the patient is breathing and assist them with extra pressure, extra volume, extra flow using that mechanical ventilator," Singer said.
Those who receive ventilators are typically the sickest patients in the hospital, and the decision to put them on a ventilator is often the last resort in an attempt to save their lives. Patients do not always recover, and there is a possibility that they acquire a case of pneumonia that they did not have prior to being put on the ventilator, Rizzo said. Their lung injuries can also be exacerbated if ventilators are not on just the right setting. (There are also patients who are on ventilators for reasons other than respiratory issues, such as those with neuromuscular diseases including ALS, or patients with brain damage.)
With illnesses like the coronavirus, which is spread through respiratory droplets, there are risks associated with ventilators for health care providers, too.
The ventilator is a closed system, so once the patient is on the ventilator, there are not necessarily extra dangers to being around them. But the process of placing the breathing tube in, called intubation, can expose health care workers to the illness through aerosols that escape from the patient's airway. These minuscule droplets can be inhaled in the absence of proper personal protective equipment, such as N95 respirator masks, which are also in short supply around the world.
"There are things in the hospital that generate aerosols, very, very fine droplet particles that can still carry the virus, can linger in the air for much longer than the droplet, and we think poses a much higher risk," Singer said.
The amount of time a patient stays on a ventilator can vary from days to weeks, experts said. At the Tulane Medical Center in New Orleans, coronavirus patients have typically been on ventilators for one or two weeks, Dr. Joshua Denson, a pulmonary medicine and critical care physician, said.
“Very few get better quickly,” meaning in fewer than three days, Denson said.
Once a patient no longer needs a ventilator, the tubing connected to it is thrown out, and the ventilator is used for the next patient after a thorough cleaning.
But without enough ventilators in their stockpiles, hospitals could be overwhelmed. In Italy, the European epicenter of the coronavirus outbreak, doctors have been forced to make heartwrenching decisions of who receives ventilators and who does not as their hospitals overflow with coronavirus patients. Fearing a similar scenario could happen in the United States, New York Gov. Andrew Cuomo has pleaded for federal assistance securing more ventilators for his state, which has over 30,000 coronavirus cases, more than any other state in this country.
The ventilators themselves are only part of what patients with significant breathing difficulties need, said Dr. David Zaas, president of Duke Raleigh Hospital and associate professor of pulmonary and critical care medicine at the Duke University School of Medicine. They also need highly trained staff monitoring them around the clock in the intensive care unit.
"We could make a million ventilators, but do we have enough respiratory therapists that are trained to care for patients on ventilators, and do we have enough nurses that are trained in caring for patients that are critically ill?" he said.
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The U.S. has approximately 160,000 ventilators, according to a 2018 analysis from the Johns Hopkins Center for Health Security, a number that experts have warned will not suffice if social distancing measures and other attempts to flatten the curve of the disease do not work quickly enough.
Health officials, lawmakers and businesses are exploring ways to get more: Car companies including General Motors and Ford are pitching in to make ventilators. And health officials in New York have proposed hooking two patients up to one ventilator at a time, something that has not been tried before.
"I think there are ways to do that and probably to do it safely, understanding that how long you want to do that for is a question we're still answering," Zaas said.
"We are all, as part of our emergency management planning, exploring how we would do things which would not be our typical care," he added. "But in atypical times, we need to come up with creative and innovative solutions to try to save lives."