Cold air will dive down from Canada and greet much of the central and eastern United States by the end of the week.
Following a swath of snow pushing through the northern tier early in the week, colder air will move in behind and move even farther south into parts of the south.
While the temperatures expected during the middle of the week will not be as brutal as the last cold spell, it will still be a drastic change.
"Before the storm that moves through the eastern half of the country, places from Chicago to Philadelphia will experience temperatures that are on the order of 5-10 degrees Fahrenheit above normal for mid-February," said AccuWeather Meteorologist Max Gawryla.
On Monday, a high of 40 is forecast in Chicago, while Philadelphia may top out at 52 on Tuesday.
Once the colder air sweeps in, the springlike temperatures will be erased and replaced with conditions more similar to January.
"Cold will send temperatures tumbling on Tuesday night across the Midwest, with lows in the single digits," added Gawryla.
Temperatures will be well below zero across parts of northern Illinois, Iowa, Wisconsin and Minnesota by Wednesday night.
By Thursday morning, temperatures will be as low as 10 to 20 degrees below zero across parts of Minnesota and Wisconsin.
Without much wind to accompany the cold, AccuWeather RealFeel® temperatures will not be too far below the actual mercury reading. During the day, when the sun is shining, RealFeel® temperatures may actually be a little higher than the normal temperature.
The coldest air, and the lowest temperatures, will wait to reach the Northeast until Friday morning.
During the morning on Friday, temperatures are expected in the single digits and teens across interior parts of the Northeast, from 14 degrees in Pittsburgh to 0 degrees in Syracuse, New York.
All of these sub-freezing temperatures will help to retain the recent snowpack across the Upper Midwest, Great Lakes and northern New England.
Although temperatures won't be subzero, the colder air will not halt in the northern tier of the country, but rather dive down into the Tennessee Valley.
"On Tuesday night, lows will remain quite mild, only falling into the mid-50s across much of the area. Just 24 hours later, low temperatures will easily drop by 20 degrees or more," said Gawryla.
Nashville's typical high in the lower 50s will be replaced by a high in the mid-40s Thursday, and will dive down into the lower 20s Thursday night. Such temperatures are about 10 degrees below normal for mid-February.
Similar drops in temperature are expected cities like Little Rock, Arkansas; Atlanta and Charlotte, North Carolina.