San Francisco Mayor Ed Lee dead at 65

San Francisco Mayor Ed Lee died just after 1 a.m. local time at Zuckerberg San Francisco General Hospital, the San Francisco Examiner reports.

"It is with profound sadness and terrible grief that we confirm that Mayor Edwin M. Lee passed away on Tuesday, December 12 at 1:11 a.m. at Zuckerberg San Francisco General Hospital. Family, friends and colleagues were at his side," his office said in a statement, according to the Examiner.

"Our thoughts and prayers are with his wife Anita, his two daughters, Brianna and Tania, and his family."

See images of Ed Lee through the years:

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Ed Lee through the years
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Ed Lee through the years
SAN FRANCISCO, CA - MAY 15: San Francisco mayor Ed Lee speaks during a news conference at the site of a street repaving project on May 15, 2017 in San Francisco, California. San Francisco mayor Ed Lee announced a two-year $90 million street repair project to repave the city's aging roads. (Photo by Justin Sullivan/Getty Images)
San Francisco Mayor Ed Lee speaks during the North American Climate Summit in Chicago, Illinois, U.S., December 5, 2017. Picture taken December 5, 2017. REUTERS/Kamil Krzaczynski
San Francisco Mayor Ed Lee (R) shakes hands with Santa Monica Mayor Ted Winterer after signing the Chicago Climate Charter during the North American Climate Summit in Chicago, Illinois, U.S., December 5, 2017. Picture taken December 5, 2017. REUTERS/Kamil Krzaczynski
CHICAGO, IL - DECEMBER 05: San Francisco Mayor Ed Lee (L), Chicago Mayor Rahm Emanuel (C) and Paris Mayor Anne Hidalgo share a laugh after posing for pictures at The North American Climate Summit on December 5, 2017 in Chicago, Illinois. The summit was held to bring together leaders from the U.S., Canada and Mexico to commit thier cities to addressing climate change at the local level. (Photo by Scott Olson/Getty Images)
San Francisco Mayor Ed Lee speaks during the North American Climate Summit in Chicago, Illinois, U.S., December 5, 2017. Picture taken December 5, 2017. REUTERS/Kamil Krzaczynski
SAN FRANCISCO, CA - NOVEMBER 28: San Francisco mayor Ed Lee sorts pears at the SF-Marin Food Bank on November 28, 2017 in San Francisco, California. A day after consumers spent billions of dollars on Cyber Monday, millions of people in the United States and in countries around the world will volunteer and donate money on Giving Tuesday. (Photo by Justin Sullivan/Getty Images)
SAN FRANCISCO, CA - AUGUST 16: Director George Nolfi (L) and actor Philip Ng (R) pose for a photo with San Francisco Mayor Ed Lee (center) at a special screening of BH Tilt & WWE Studios' 'Birth of the Dragon' at the AMC Dine-In Kabuki 8 theater on August 16, 2017 in San Francisco, California. (Photo by Kelly Sullivan/Getty Images for Blumhouse Productions, LLC)
SAN FRANCISCO, CA - JANUARY 13: San Francisco Mayor Ed Lee (R) looks on as Dr. Suzanne Barakat speaks during a news conference at the Islamic Society of San Francisco on January 13, 2017 in San Francisco, California. Lee announced the launch of the Equity and Immigrant Services campaign that will provide support for immigration related legal services. (Photo by Justin Sullivan/Getty Images)
SAN FRANCISCO, CA - JANUARY 13: San Francisco Mayor Ed Lee speaks during a news conference at the Islamic Society of San Francisco on January 13, 2017 in San Francisco, California. Lee announced the launch of the Equity and Immigrant Services campaign that will provide support for immigration related legal services. (Photo by Justin Sullivan/Getty Images)
CHICAGO, IL - DECEMBER 05: Vancouver Mayor Gregor Robertson, San Francisco Mayor Ed Lee (L), Chicago Mayor Rahm Emanuel (C), Paris Mayor Anne Hidalgo and Portland, Oregon Mayor Ted Wheeler gather for a picture at The North American Climate Summit on December 5, 2017 in Chicago, Illinois. The summit was held to bring together leaders from the U.S., Canada and Mexico to commit thier cities to addressing climate change at the local level. (Photo by Scott Olson/Getty Images)
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Lee will be succeeded by San Francisco Board of Supervisors President London Breed. Lee was originally appointed by the board as mayor in 2011, and won reelection in 2015.

As of Tuesday morning Lee's cause of death remains unclear.

As recently as last week, Lee joined his "Fix-It Team" cleaning up the streets of the city and addressing quality of life issues.

Lee presided over San Francisco during pivotal years when Silicone Valley giants took off and revolutionized industry while causing home prices in his city to skyrocket.

But Lee's run as mayor ran into international controversy recently, when he accepted a statue from South Korea commemorating the "comfort women" who the Japanese military used as sex slaves during World War II.

As a result, Osaka ended its "sister city" relationship with San Francisco.

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