South Carolina, Xavier among biggest upsets of March Madness so far

After a whirlwind of First and Second Round games, March Madness moves on with 16 teams left advancing to the next series of play.

Most NCAA tournaments include a few major upsets -- that is, lower-seeded teams defeating higher-seeded squads in bracket-busting victories. This year, a select number of March Madness' first weekend match-ups fell nothing short of stunning.

Here is a rundown of the biggest March Madness upsets to date:

South Carolina (7) over Duke (2)

No. 7 seed South Carolina defeated No. 2 seed Duke in a stunning 88-81 upset victory on Sunday night. A tournament favorite to win the championship by many expert standards, this was the greatest upset of the tournament thus far.

The South Carolina Gamecocks scored 65 points in the second half alone against the Blue Devils, after shooting 7-for-35 in the first 20 minutes of play. SEC Player of the Year Sindarius Thornwell led the Gamecocks in scoring with 24 points.

SEE ALSO: Full NCAA tournament schedule

The game was also played in Greenville, South Carolina after the NCAA pulled tournament play out of North Carolina in protest of the state's anti-transgender HB2 bathroom bill. The semi-home play advantage may have contributed to the Gamecocks victory.

South Carolina faces Baylor on Friday.

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UNC

NCAA seed: 3

Bovada odds: +140

Vegas Insider: 8/5

Updated March 27, 2017

Gonzaga

NCAA seed: 4

Bovada odds: +180

Vegas Insider: 3/2

Updated March 27, 2017

South Carolina

NCAA seed: 26

Bovada odds: +750

Vegas Insider: 8/1

Updated March 27, 2017

Oregon

NCAA seed: 9

Bovada odds: +550

Vegas Insider: 4/1

Updated March 27, 2017

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Wisconsin (8) over Villanova (1)

The defending NCAA champion Villanova squad suffered a 65-62 loss against the Wisconsin Badgers last Saturday, when they became the first No. 1 seed to exit the 2017 tournament.

Villanova had a chance to tie after Wisconsin's Vitto Brown missed a free throw, but the attempt fell short.

Wisconsin faces Florida on Friday.

Xavier (11) over Maryland (6) and Florida State (3)

No. 11 seed Xavier enters the Sweet Sixteen with the worst odds out of any other team, but has proven their worth on the court so far with upset victories over both No. 6 seed Maryland and No. 3 seed Florida State. The Xavier Musketeers defeated Maryland 76-65 in the First Round, and went on to trample the Florida State Seminoles 91-66. Xavier's Trevon Bluiett put up 29 points against FSU, while Kaiser Gates came off the bench to put up a respective 14 points.

Xavier faces Arizona on Thursday.

RELATED: Maryland vs. Xavier -- March Madness 2017

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Maryland vs. Xavier -- March Madness 2017
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Maryland vs. Xavier -- March Madness 2017
ORLANDO, FL - MARCH 16: Sean O'Mara #54 of the Xavier Musketeers dunks the ball against Damonte Dodd #35 of the Maryland Terrapins in the first half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
Mar 16, 2017; Orlando, FL, USA; Maryland Terrapins forward Damonte Dodd (35) defends against Xavier Musketeers guard Trevon Bluiett (5) during the first half in the first round of the NCAA Tournament at Amway Center. Mandatory Credit: Logan Bowles-USA TODAY Sports
ORLANDO, FL - MARCH 16: Sean O'Mara #54 of the Xavier Musketeers dunks the ball against Damonte Dodd #35 of the Maryland Terrapins in the first half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
Mar 16, 2017; Orlando, FL, USA; Maryland Terrapins guard Kevin Huerter (4) shoots against Xavier Musketeers guard Trevon Bluiett (5) and forward Sean O'Mara (54) during the second half in the first round of the NCAA Tournament at Amway Center. Mandatory Credit: Logan Bowles-USA TODAY Sports
Mar 16, 2017; Orlando, FL, USA; General view of the March Madness logo prior to the game between the Maryland Terrapins and the Xavier Musketeers in the first round of the NCAA Tournament at Amway Center. Mandatory Credit: Kim Klement-USA TODAY Sports
Mar 16, 2017; Orlando, FL, USA; Maryland Terrapins guard Kevin Huerter (4) and Xavier Musketeers guard Trevon Bluiett (5) go after a loose ball during the first half in the first round of the NCAA Tournament at Amway Center. Mandatory Credit: Kim Klement-USA TODAY Sports
ORLANDO, FL - MARCH 16: Sean O'Mara #54 of the Xavier Musketeers and RaShid Gaston #35 react after defeating the Maryland Terrapins 76-65 in the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: Melo Trimble #2 of the Maryland Terrapins reacts after being defeated by the Xavier Musketeers 76-65 in the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
Mar 16, 2017; Orlando, FL, USA; General view of a March Madness basketball prior to the game between the Maryland Terrapins and the Xavier Musketeers in the first round of the NCAA Tournament at Amway Center. Mandatory Credit: Kim Klement-USA TODAY Sports
ORLANDO, FL - MARCH 16: Kaiser Gates #22 of the Xavier Musketeers shoots the ball in the second half against the Maryland Terrapins during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
ORLANDO, FL - MARCH 16: Ivan Bender #13 of the Maryland Terrapins and Sean O'Mara #54 of the Xavier Musketeers battle for position during a free throw in the second half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
ORLANDO, FL - MARCH 16: Actor Bill Murray reacts during the game between the Xavier Musketeers and the Maryland Terrapins in the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
ORLANDO, FL - MARCH 16: Maryland Terrapins cheerleaders perform during the game between the Xavier Musketeers and the Maryland Terrapins in the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
ORLANDO, FL - MARCH 16: Anthony Cowan #0 of the Maryland Terrapins shoots a free throw in the first half against the Xavier Musketeers during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: (L-R) Kaiser Gates #22 of the Xavier Musketeers, Justin Jackson #21 of the Maryland Terrapins and J.P. Macura #55 of the Xavier Musketeers battle for position during a free throw in the first half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
ORLANDO, FL - MARCH 16: Sean O'Mara #54 of the Xavier Musketeers dunks the ball against Damonte Dodd #35 of the Maryland Terrapins in the first half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: Malcolm Bernard #11 of the Xavier Musketeers battles for the ball with Justin Jackson #21 of the Maryland Terrapins in the second half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: Trevon Bluiett #5 of the Xavier Musketeers reacts in the second half against the Maryland Terrapins during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: Head coach Mark Turgeon of the Maryland Terrapins reacts in the second half against the Xavier Musketeers during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: Head coach Chris Mack of the Xavier Musketeers reacts in the second half against the Maryland Terrapins during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: Justin Jackson #21 of the Maryland Terrapins dunks the ball against Sean O'Mara #54 of the Xavier Musketeers in the first half during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
ORLANDO, FL - MARCH 16: J.P. Macura #55 of the Xavier Musketeers sits next to the scorer's table in the first half against the Maryland Terrapins during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Mike Ehrmann/Getty Images)
ORLANDO, FL - MARCH 16: Trevon Bluiett #5 of the Xavier Musketeers attempts to handle the ball in the first half against the Maryland Terrapins during the first round of the 2017 NCAA Men's Basketball Tournament at Amway Center on March 16, 2017 in Orlando, Florida. (Photo by Rob Carr/Getty Images)
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Middle Tennessee (12) over Minnesota (5)

The No. 12 seeded Middle Tennessee defeated No. 5 seed Minnesota in the First Round last week, in a 81-72 victory. Although Middle Tennessee was technically the lower-seeded team, the Blue Raiders were actually the Vegas favorite by 1.5 points. While Vegas did not consider this an upset, they were -- nevertheless -- the lower-seeded team.

Middle Tennessee was eliminated in the Second Round by Butler.

Rhode Island (11) over Creighton (6)

In their first NCAA tournament appearance since 1999, No. 11 seed Rhode Island defeated No. 6 seed Creighton 84-72 in the First Round last week.

Rhode Island outscored Creighton 11-4 in the first seven minutes as both teams struggled to get into offensive rhythm. The Rams went up 15-8 on a jumper by Iverson before the Bluejays came back to tie the game on a 3-pointer by Cole Huff.

URI was defeated by Oregon in the Second Round.

RELATED: Nate Silver's top March Madness picks for Sweet Sixteen

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Nate Silver's top March Madness picks
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Nate Silver's top March Madness picks

Gonzaga: 42%

Updated March 27, 2017

UNC: 24%

Updated March 27, 2017

Oregon: 21%

Updated March 27, 2017

South Carolina: 14%

Updated March 27, 2017

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