Here are the 'most wanted' superbugs that desperately need new drugs to fight them


The World Health Organization has just released its own version of the FBI's Most Wanted List, but its targets are much more elusive than any single person could be.

On Monday, the WHO published a rogues' gallery of the antibiotic-resistant bacteria that are the most high-priority targets for new drugs. The list, created at the behest of the WHO's member states, is made up of 12 bacterial families and categorized by the level of urgent attention they deserve. The superbugs range from common infections, like the germ behind the STD gonorrhea, to those rarer but nearly untreatable with conventional drugs, like a family of bacteria called Carbapenem-resistant Enterobacteriaceae (CRE) that can resist the last line of effective antibiotics we have available.

"This list is a new tool to ensure R&D responds to urgent public health needs," said Dr. Marie-Paule Kieny, WHO's Assistant Director-General for Health Systems and Innovation, in a statement. "Antibiotic resistance is growing, and we are fast running out of treatment options. If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time."

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Superbugs: Victims and outbreaks
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Superbugs: Victims and outbreaks
Kelly and Ryan Breaux stand holding a portrait of their deceased daughter Emma Breaux, at their home in Breaux Bridge, Louisiana, on June 16, 2016. The husband and wife lost twins, Emma and Talon, to different superbugs that they contracted while in the neonatal unit at Lafayette General Hospital. U.S. Picture taken June 16, 2016. TO MATCH SPECIAL REPORT USA-UNCOUNTED/SURVEILLANCE REUTERS/Edmund Fountain
Kelly and Ryan Breaux sit holding a portrait of their deceased daughter Emma Breaux in their home in Breaux Bridge, Louisiana, on June 16, 2016. The husband and wife lost twins, Emma and Talon, to different superbugs that they contracted while in the neonatal unit at Lafayette General Hospital. U.S. Picture taken June 16, 2016. TO MATCH SPECIAL REPORT USA-UNCOUNTED/SURVEILLANCE REUTERS/Edmund Fountain
Four-year-old Luke Reimer, of Batavia, Illinois, holds a photograph, June 18, 2009, of his twin sister Madeline who died after being born with MRSA (Methicillin resistant Staphylococcus aureus), a bacterium that is resistant to many antibiotics. (Photo by Chuck Berman/Chicago Tribune/MCT via Getty Images)
Stephanie Hall (L), sits on the couch with her sister, Crystal Silva (R), and their ten year old niece Destini and nephew Kane in El Paso, Texas, U.S. on July 2, 2016. The children's mother, Natalie Silva, contracted Methicillin-resistant Staphylococcus aureus, more commonly known as MRSA, a skin infection that can turn fatal once it enters the bloodstream, when she went to the hospital to deliver Kane. After a 10 month battle with MRSA, Silva died, leaving Hall and the family to raise the two children. TO MATCH SPECIAL REPORT USA-UNCOUNTED/SURVEILLANCE REUTERS/Dan Dalstra
Monica Berckes, poses with the funeral program of her late mother Marianne Rumsey, who died at 61, several months after contracting MRSA during heart surgery, at her home in Secaucus, New Jersey, June 2, 2016. Picture taken June 2, 2016. TO MATCH SPECIAL REPORT USA-UNCOUNTED/SURVEILLANCE REUTERS/Mike Segar
Zachary Rubin (C), medical director of clinical epidemiology and infection prevention, and Robert Cherry (R), chief medical and quality officer for UCLA Health System, attend a news conference by UCLA Health System and county officials at the Ronald Reagan UCLA Medical Center in Los Angeles, California February 19, 2015. The large Los Angeles teaching hospital has told scores of patients they were possibly exposed to a drug-resistant bacterial "superbug" during endoscopy procedures that infected seven patients and may have contributed to two deaths. REUTERS/Jonathan Alcorn (UNITED STATES - Tags: HEALTH DISASTER)
A sample bottle containing E. coli bacteria is seen at the Health Protection Agency in north London March 9, 2011. For decades scientists have managed to develop new medicines to stay at least one step ahead of the ever-mutating enemy, bacteria. Now, though, we may be running out of road. Methicillin-resistant Staphylococcus aureus, commonly known as MRSA, alone is estimated to kill around 19,000 people every year in the United States -- far more than HIV and AIDS -- and a similar number in Europe, and other drug-resistant superbugs are spreading. Picture taken March 9, 2011. To match Special Report ANTIBIOTICS/ REUTERS/Suzanne Plunkett (BRITAIN - Tags: HEALTH SCI TECH)
An employee displays MRSA (Methicillin-resistant Staphylococcus aureus) bacteria strain inside a petri dish containing agar jelly for bacterial culture in a microbiological laboratory in Berlin March 1, 2008. MRSA is a drug-resistant "superbug", which can cause deadly infections. REUTERS/Fabrizio Bensch (GERMANY)
A view of the UCLA Medical Center in Los Angeles, California March 19, 2015. UCLA, the hospital at the center of the "superbug" outbreak that killed two people and infected seven last month has received poor patient safety scores and had its payments cut by Medicare for high rates of hospital-acquired infections. REUTERS/Lucy Nicholson
This digitally-colorized scanning electron micrograph depicts four magenta-colored, spherical methicillin-resistant Staphylococcus aureus (MRSA) bacteria in the process of being phagocytized by a blue-colored human white blood cells in this undated handout photo. TO MATCH SPECIAL REPORT USA-UNCOUNTED/SURVEILLANCE National Institute of Allergy and Infectious Diseases (NIAID)/Handout via REUTERS ATTENTION EDITORS - THIS IMAGE WAS PROVIDED BY A THIRD PARTY. EDITORIAL USE ONLYONLY
MIAMI - OCTOBER 17: Miami VA Medical Center hospital registered nurse, Rafael Sepulveda, pulls on rubber gloves while attending to patients in the Emergency room October 17, 2007 in Miami, Florida. The hospital has strict policies in place to ensure that the staff uses procedures in the fight against methicillin-resistant Staphylococcus aureus bacteria, commonly referred to as MRSA. The staph bacterium is resistant to most common antibiotics and has been responsible for more than nearly 19,000 deaths each year, according to the Centers for Disease Control and Prevention (Photo by Joe Raedle/Getty Images)
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The three most crucial superbugs, which includes CRE, are all often deadly hospital infections that are resistant to the last-line antibiotic carbapenems. What makes these germs even more dangerous is that because of their structure, they are hard to treat with antibiotics to begin with. By the time they've picked up the gene mutations that lets them shrug off carbapenems, some strains have already learned to resist every other antibiotic in the arsenal, making them pan-resistant.

More: The Attack Of The Superbugs

Those under the high priority category include less hardy but still dangerous bacteria like Staphylococcus aureus strains that are resistant to common antibiotics as well as vancomycin, a last-resort drug for staph; Salmonella strains that are resistant to fluoroquinolones and cause food poisoning; and Helicobacter pylori strains that are resistant to the first line drug clarithromycin and often cause chronic ulcers. And those under the medium priority umbrella include resistant Streptococcus pneumoniae, a common cause of pneumonia, and resistant Shigella, a foodborne germ.

Though the list does include many of the most dangerous antibiotic-resistant bacteria around, their order doesn't necessarily reflect their overall public health priority. Rather, it's intended as a spotlight for superbugs that need more funding and research. Indeed, one noticeable absence is multidrug-resistant tuberculosis, left off because there are already well-established programs that have driven down rates of resistant TB over time.

Health agencies like the Centers for the Disease Control and Prevention have created their own superbug list in recent years, though, more explicitly based on their public health threat. But just like the WHO's list, CREs are at the top of the heap.

It's expected that antibiotic resistance, and the WHO's list, will be one of the topics discussed at a preliminary conference of the G20 summit to be held later this week in Berlin, Germany. The annual summit itself, an international forum of representatives from 20 major economies brought together to discuss global issues, will be held later this July in Hamburg.

The post Here Are The 'Most Wanted' Superbugs That Desperately Need New Drugs appeared first on Vocativ.

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