WATCH: Democrats mount major Senate floor protest against Betsy DeVos

UPDATE: This event has ended.

Senate Democrats announced on Monday that they have launched a marathon session on the Senate floor ahead of the confirmation vote for President Donald Trump's education secretary pick, Betsy DeVos, in an attempt to derail her confirmation.

"Democrats will hold the floor for the next 24 hours, until the final vote, to do everything we can to persuade just one more Republican to join us," Sen. Patty Murray of Washington said Monday. "And I strongly encourage people across the country to join us — to double down on your advocacy — and to keep making your voices heard for these last 24 hours."

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Betsy DeVos through the years

Continuing a day of one-on-one meetings with candidates for positions in his cabinet, President-elect Donald Trump met with Betsy DeVos, two polar opposites thought to be in contention for the education portfolio.

(Photo by Andy Katz/Pacific Press/LightRocket via Getty Images)

U.S. President-elect Donald Trump and Vice President-elect Mike Pence stand with Betsy DeVos before their meeting at the main clubhouse at Trump National Golf Club in Bedminster, New Jersey, U.S., November 19, 2016.

(REUTERS/Mike Segar)

U.S. President-elect Donald Trump and Vice President-elect Mike Pence emerge with Betsy DeVos after their meeting at the main clubhouse at Trump National Golf Club in Bedminster, New Jersey, U.S., November 19, 2016.

(REUTERS/Mike Segar)

Continuing a day of one-on-one meetings with candidates for positions in his cabinet, President-elect Donald Trump and Vice President Mike Pence met with Betsy DeVos, two polar opposites thought to be in contention for the education portfolio.

(Photo by Andy Katz/Pacific Press/LightRocket via Getty Images)

Grant Hill #33 of the Los Angeles Clippers shakes hands with Owner Dick DeVos, Chairman of Amway and his wife Betsy DeVos during the game against the Orlando Magic during the game on February 6, 2013 at Amway Center in Orlando, Florida.

(Photo by Fernando Medina/NBAE via Getty Images)

US President George W. Bush and First Lady Laura Bush wave after they were introduced by the Chair of the Michigan Republican Party Betsy DeVos 30 October 2004 in Grand Rapids, Michigan. Bush is on his final three days of campaigning prior for the election November 02.

(STEPHEN JAFFE/AFP/Getty Images)

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Democrats will be speaking out against DeVos, who Senate Minority Leader Chuck Schumer called "least qualified nominee in a historically unqualified cabinet," in an effort to court one more GOP senator to oppose her nomination.

Democrats have complained that DeVos, a billionaire businesswoman, is unqualified to hold position and accuse her of failing to understand education and being fundamentally opposed to public schools. Her business ties have also been questioned.

Two Republican senators, Sens. Susan Collins of Maine and Lisa Murkowski of Alaska, announced plans to oppose her, which could result in a 50-50 Senate vote Tuesday afternoon, forcing Vice President Mike Pence to cast a rare tie-breaking vote.

If Democrats can convince an additional Republican to join them in opposing DeVos, they can block Trump's pick.

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