WATCH: Democrats mount major Senate floor protest against Betsy DeVos

UPDATE: This event has ended.

Senate Democrats announced on Monday that they have launched a marathon session on the Senate floor ahead of the confirmation vote for President Donald Trump's education secretary pick, Betsy DeVos, in an attempt to derail her confirmation.

"Democrats will hold the floor for the next 24 hours, until the final vote, to do everything we can to persuade just one more Republican to join us," Sen. Patty Murray of Washington said Monday. "And I strongly encourage people across the country to join us — to double down on your advocacy — and to keep making your voices heard for these last 24 hours."

RELATED: Betsy DeVos through the years

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Betsy DeVos through the years
U.S. Education Secretary Betsy DeVos speaks at Harvard University's Kennedy School of Government in Cambridge, Massachusetts, U.S., September 28, 2017. REUTERS/Mary Schwalm

Continuing a day of one-on-one meetings with candidates for positions in his cabinet, President-elect Donald Trump met with Betsy DeVos, two polar opposites thought to be in contention for the education portfolio.

(Photo by Andy Katz/Pacific Press/LightRocket via Getty Images)

U.S. Secretary of Education Betsy DeVos, U.S. first lady Melania Trump and Jordan?s Queen Rania speak with students and administrators at the Excel Academy public charter school in Washington, U.S., April 5, 2017. REUTERS/Joshua Roberts
U.S. Secretary of Education Betsy DeVos speaks before U.S. President Donald Trump signed a memorandum "Increasing Access to High-Quality Science, Technology, Engineering and Math (STEM) Education" in the Oval Office of the White House in Washington, U.S., September 25, 2017. REUTERS/Joshua Roberts
WASHINGTON, DC - OCTOBER 30: U.S. Education Secretary Betsy DeVos (L), who was dressed as Ms. Frizzle from 'The Magic Schoolbus' series, and Counselor to the President Kellyanne Conway attend Halloween at the White House on the South Lawn October 30, 2017 in Washington, DC. President Donald Trump and first lady Melania Trump gave cookies away to costumed trick-or-treaters one day before the Halloween holiday. (Photo by Chip Somodevilla/Getty Images)

U.S. President-elect Donald Trump and Vice President-elect Mike Pence stand with Betsy DeVos before their meeting at the main clubhouse at Trump National Golf Club in Bedminster, New Jersey, U.S., November 19, 2016.

(REUTERS/Mike Segar)

Continuing a day of one-on-one meetings with candidates for positions in his cabinet, President-elect Donald Trump and Vice President Mike Pence met with Betsy DeVos, two polar opposites thought to be in contention for the education portfolio.

(Photo by Andy Katz/Pacific Press/LightRocket via Getty Images)

U.S. President Donald Trump (C, background) waits to interrupt Education Secretary Betsy DeVos as she speaks to students at a school choice event at the White House in Washington, U.S. May 3, 2017. REUTERS/Jonathan Ernst

Grant Hill #33 of the Los Angeles Clippers shakes hands with Owner Dick DeVos, Chairman of Amway and his wife Betsy DeVos during the game against the Orlando Magic during the game on February 6, 2013 at Amway Center in Orlando, Florida.

(Photo by Fernando Medina/NBAE via Getty Images)

US President George W. Bush and First Lady Laura Bush wave after they were introduced by the Chair of the Michigan Republican Party Betsy DeVos 30 October 2004 in Grand Rapids, Michigan. Bush is on his final three days of campaigning prior for the election November 02.

(STEPHEN JAFFE/AFP/Getty Images)

Education Secretary Betsy DeVos makes remarks during a major policy address on Title IX enforcement, which in college covers sexual harassment, rape and assault, at George Mason University, in Arlington, Virginia, U.S., September 7, 2017. REUTERS/Mike Theiler
U.S. Secretary of Education Betsy DeVos and U.S. first lady Melania Trump are greeted by a student during a visit the Excel Academy public charter school in Washington, U.S., April 5, 2017. REUTERS/Joshua Roberts
U.S. Secretary of Education Betsy DeVos (C) and Secretary of Health and Human Services (HHS) Tom Price (R) attend a cabinet meeting with President Donald Trump at the White House in Washington, U.S. March 13, 2017. REUTERS/Jonathan Ernst
U.S. President Donald Trump, joined by U.S. Senator Marco Rubio (from L), advisor Jared Kushner and U.S. Education Secretary Betsy DeVos, thanks fourth-grade students Janayah Chatelier (3rd R) and Landon Fritz (R) for the "Happy Birthday Florida" card they gave him as he visits their classroom at Saint Andrew Catholic School in Orlando, Florida, U.S. March 3, 2017. REUTERS/Jonathan Ernst
U.S. President Donald Trump talks to U.S. Secretary of Education Betsy DeVos during a meeting with teachers and parents at the White House in Washington, U.S., February 14, 2017. REUTERS/Kevin Lamarque
U.S. Education Secretary Betsy DeVos (2nd R) and U.S. Senator Marco Rubio (R-FL) (R) arrive with President Donald Trump aboard Air Force One at Orlando International Airport in Orlando, Florida, U.S. March 3, 2017. REUTERS/Jonathan Ernst
CAMBRIDGE, MA - SEPTEMBER 28: U.S. Secretary of Education Betsy DeVos speaks in a forum at Harvard University Kennedy School of Government on Thursday, September 28, 2017. (Photo by Katye Martens Brier for The Washington Post via Getty Images)

U.S. President-elect Donald Trump and Vice President-elect Mike Pence emerge with Betsy DeVos after their meeting at the main clubhouse at Trump National Golf Club in Bedminster, New Jersey, U.S., November 19, 2016.

(REUTERS/Mike Segar)

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Democrats will be speaking out against DeVos, who Senate Minority Leader Chuck Schumer called "least qualified nominee in a historically unqualified cabinet," in an effort to court one more GOP senator to oppose her nomination.

Democrats have complained that DeVos, a billionaire businesswoman, is unqualified to hold position and accuse her of failing to understand education and being fundamentally opposed to public schools. Her business ties have also been questioned.

Two Republican senators, Sens. Susan Collins of Maine and Lisa Murkowski of Alaska, announced plans to oppose her, which could result in a 50-50 Senate vote Tuesday afternoon, forcing Vice President Mike Pence to cast a rare tie-breaking vote.

If Democrats can convince an additional Republican to join them in opposing DeVos, they can block Trump's pick.

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