"I am sick and tired of the negative, dark, divisive, dangerous vision and the anger of people who support Donald Trump," Clinton said as she pointed a finger at the protester.
The heckler began shouting: "Bill Clinton is a rapist" at the top of the Democratic presidential candidate's 20-minute speech. The heckler also held a sign with the phrase written on it.
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"We're not going backwards, we're going forward into a brighter future," Clinton said as the crowd began to chant "Hillary! Hillary! Hillary!"
Clinton's security detail quickly removed the heckler from the audience.
See photos of Bill and Hillary through the years:
Bill Clinton and Hillary Clinton through the years
Bill Clinton and Hillary Clinton through the years
FILE WASHINGTON, DC - JAN 6, 1994:
President Bill Clinton is escorted by Hillary to a waiting helicopter. The president was leaving for Arkansas after learning of the death of his mother.
(Photo by Margaret Thomas/The Washington Post via Getty Images)
US Secretary of State Hillary Clinton (L) and US President barack Obama (R) are greeted by Myanmar pro-democracy leader Aung San Suu Kyi (C) at her residence in Yangon on November 19, 2012 . Obama arrived in Myanmar for a historic visit aimed at encouraging a string of dramatic political reforms in the former pariah state. AFP PHOTO / Nicolas ASFOURI (Photo credit should read NICOLAS ASFOURI/AFP/Getty Images)
US Secretary of State Hillary Clinton (L) looks on as US President Barack Obama (2nd L) speaks during a bilateral meeting with Japanese Prime Minister Yoshihiko Noda (2nd R) on the sidelines of the East Asian Summit at the Peace Palace in Phnom Penh on November 20, 2012. During the two-day East Asia Summit in Phnom Penh, Obama was scheduled to hold talks with the leaders of the 10-member Association of Southeast Asian Nations (ASEAN) along with Chinese Premier Wen Jiabao and Japan's Yoshihiko Noda. AFP PHOTO / Jewel Samad (Photo credit should read JEWEL SAMAD/AFP/Getty Images)
US President Barack Obama and Secretary of State Hillary Clinton board Air Force One at the airport in Yangon on November 19, 2012. Huge crowds greeted Barack Obama in Myanmar on the first visit by a serving US president to the former pariah state to encourage a string of startling political reforms. AFP PHOTO/Jewel Samad (Photo credit should read JEWEL SAMAD/AFP/Getty Images)
US President Barack Obama(2nd-L), First Lady Michelle Obama(L) along with former president Bill Clinton(3rd-L) and former secretary of state Hillary Clinton(4th-L) take part in a wreath-laying ceremony in honour of the late 35th president of the US John F. Kennedy at Kennedy's gravesite in Arlington National Cemetery on November 20, 2013 in Arlington, Virginia. AFP PHOTO/Mandel NGAN (Photo credit should read MANDEL NGAN/AFP/Getty Images)
BERLIN, GERMANY - JULY 06: Copies of the German translation of the book 'Hard Choices' ('Entscheidungen' in German) by Hillary Rodham Clinton, former United States Secretary of State, U.S. Senator, and First Lady of the United States, stand on display at the Staatsoper in the Schiller Theater on July 6, 2014 in Berlin, Germany. (Photo by Adam Berry/Getty Images)
BERLIN, GERMANY - JULY 06: Hillary Rodham Clinton, former United States Secretary of State, U.S. Senator, and First Lady of the United States, speaks during the presentation of the German translation of her book 'Hard Choices' ('Entscheidungen' in German) at the Staatsoper in the Schiller Theater on July 6, 2014 in Berlin, Germany. (Photo by Adam Berry/Getty Images)
AUSTIN, TX - JUNE 20: Hillary Rodham Clinton appears on stage during 'A Conversation With Former Secretary of State Hillary Rodham Clinton' at the Long Center on June 20, 2014 in Austin, Texas. (Photo by Gary Miller/Getty Images)
BERLIN, GERMANY - JULY 06: Hillary Rodham Clinton, former United States Secretary of State, U.S. Senator, and First Lady of the United States (R), speaks next to Christoph Amend, editor in chief of Zeit Magazin, during the presentation of the German translation of her book 'Hard Choices' ('Entscheidungen' in German) at the Staatsoper in the Schiller Theater on July 6, 2014 in Berlin, Germany. (Photo by Adam Berry/Getty Images)
EAST HAMPTON, NY - AUGUST 16: Hillary Rodham Clinton signs copies of her book 'Hard Choices' at BookHampton on August 16, 2014 in East Hampton, New York. (Photo by Sonia Moskowitz/Getty Images)
OAKLAND, CA - JULY 23: Former Secretary of State Hillary Clinton speaks during a during a round table event to launch the 'Talking is Teaching: Talk Read Sing' campaign at the
Children's Hospital Oakland Research Institute on July 23, 2014 in Oakland, California. Former Secretary of State Hillary Clinton launched the 'Talking is Teaching; Talk Read Sing' campaign in partnership withToo Small to Fail and the Bill, Hillary and Chelsea Foundation that encourages parents and caregivers to close the word gap by talking, singing and reading to children every day from the birth. (Photo by Justin Sullivan/Getty Images)
NEW YORK, NY - JANUARY 06: Former president of United States (US) Bill Clinton (R) and his wife, former US Secretary of State Hillary Clinton (L), leave St. Ignatius Loyola Church after the funeral of former three-term governor Mario Cuomo on January 6, 2015 in New York City. (Photo by Selcuk Acar/Anadolu Agency/Getty Images)
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On Tuesday evening, Donald Trump campaigned in Wisconsin and encouraged early voters who went for Clinton to switch their choice to him.
This is a message for any Democratic voters who have already cast their ballots for Hillary Clinton and are having a bad case of buyers' remorse — in other words, you want to change your vote. Wisconsin is one of several states where you can change your early ballot if you think you've made a mistake," Trump said. "We'll make America great again."