Debate goes off the rails as Donald Trump unleashes on moderators: 'It's one-on-three'

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The second presidential debate hit a contentious stretch when Donald Trump criticized both his Democratic opponent Hillary Clinton and the debate moderators.

Midway through Sunday's debate, Trump aggressively condemned Clinton's use of a private email server while serving as secretary of state. When Trump interjected during Clinton's response, Cooper told Trump to let the Democratic presidential nominee speak.

"Please allow her to respond, she didn't talk while you talked," Cooper said.

"That's true, I didn't," Clinton said, smiling.

"Because you had nothing to say," Trump shot back.

See photos from the tense debate:

43 PHOTOS
Donald Trump, Hillary Clinton take the stage for the second presidential debate
See Gallery
Donald Trump, Hillary Clinton take the stage for the second presidential debate
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton acknowledge each other at the start of their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton stand together at the start of their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump speaks as Democratic U.S. presidential nominee Hillary Clinton listens during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Lucy Nicholson
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton appear together during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Mike Segar
Republican U.S. presidential nominee Donald Trump listens as Democratic U.S. presidential nominee Hillary Clinton speaks during their presidential town hall debate with at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Saul Loeb/Pool
Democratic U.S. presidential nominee Hillary Clinton speaks during their presidential town hall debate with Republican U.S. presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Saul Loeb/Pool
Republican U.S. presidential nominee Donald Trump speaks at the start of the second U.S. presidential town hall debate between Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump speaks as Democratic U.S. presidential nominee Hillary Clinton listens and takes notes during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump turns his back as Democratic U.S. presidential nominee Hillary Clinton talks about his comments about women during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Bourg
Moderators Anderson Cooper and Martha Raddatz speak before the start of the second U.S. presidential debate between Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Melania Trump, Ivanka Trump, Eric Trump and Donald Trump Jr. stand before the presidential town hall debate between Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016.
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton acknowledge each other at the start of their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Saul Loeb/Pool
Republican U.S. presidential nominee Donald Trump speaks during the second U.S. presidential town hall debate between Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump speaks as Democratic U.S. presidential nominee Hillary Clinton listens during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Democratic U.S. presidential nominee Hillary Clinton speaks during the second U.S. presidential town hall debate between Clinton and Republican U.S. presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Democratic U.S. presidential nominee Hillary Clinton listens during their presidential town hall debate with Republican U.S. presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Rick Wilking
The family of U.S. Republican presidential nominee Donald Trump, (L-R) Melania, Ivanka, Eric and Donald Jr. wait for the presidential town hall debate with U.S. Democratic presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S. October 9, 2016. REUTERS/Brian Snyder
Marc Mezvinsky, Chelsea Clinton and Former U.S. President Bill Clinton sit at the presidential town hall debate between Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Bourg
Republican U.S. presidential nominee Donald Trump listens as Democratic nominee Hillary Clinton answers a question from the audience during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Rick Wilking
Democratic U.S. presidential nominee Hillary Clinton speak during her debate against Republican U.S. presidential nominee Donald Trump (L) at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump speaks during his presidential town hall debate against Democratic U.S. presidential nominee Hillary Clinton (not shown) at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Aaron P. Bernstein
Republican U.S. presidential nominee Donald Trump speaks during the presidential town hall debate with Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Shannon Stapleton TPX IMAGES OF THE DAY
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton speak during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young TPX IMAGES OF THE DAY
U.S. Democratic presidential nominee Hillary Clinton and her husband, former U.S. President Bill Clinton, board her campaign plane after the presidential town hall debate against U.S. Republican presidential nominee Donald Trump in St. Louis, Missouri, U.S. October 9, 2016. REUTERS/Brian Snyder
Former U.S. President Bill Clinton watches as Republican U.S. presidential nominee Donald Trump (L) and his wife, Democratic U.S. presidential nominee Hillary Clinton, participate in their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Shannon Stapleton
Democratic U.S. presidential nominee Hillary Clinton speaks during their presidential town hall debate with Republican U.S. presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Lucy Nicholson
Republican U.S. presidential nominee Donald Trump speaks during the presidential town hall debate with Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Shannon Stapleton
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton pause at the conclusion of their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Saul Loeb/Pool
Republican U.S. presidential nominee Donald Trump speaks as Democratic U.S. presidential nominee Hillary Clinton listens during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Saul Loeb/Pool
Democratic U.S. presidential nominee Hillary Clinton speaks during the presidential town hall debate with Republican U.S. presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Lucy Nicholson
Republican U.S. presidential nominee Donald Trump listens as Democratic U.S. presidential nominee Hillary Clinton speaks during their presidential town hall debate with at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Shannon Stapleton
(L-R) Kathleen Willey, Juanita Broaddrick and Kathy Shelton sit together in the audience before Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton begin their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Mike Segar
Republican U.S. presidential nominee Donald Trump speaks as Democratic U.S. presidential nominee Hillary Clinton listens during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Lucy Nicholson
Republican U.S. presidential nominee Donald Trump's daughters-in-laws Lara Trump, Vanessa Trump and daughter Tiffany Trump (L-R) are seated at the start of the second U.S. presidential town hall debate between Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Chelsea Clinton and Former U.S. President Bill Clinton arrive at the presidential town hall debate between Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Rick Wilking
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton face the audience during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Lucy Nicholson
Republican U.S. presidential nominee Donald Trump looks at Democratic U.S. presidential nominee Hillary Clinton during their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young TPX IMAGES OF THE DAY
Republican U.S. presidential nominee Donald Trump is seen during his presidential town hall debate against Democratic U.S. presidential nominee Hillary Clinton (not shown) at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Journalists Anderson Cooper and Martha Raddatz prepare to moderate the presidential town hall debate between U.S. Democratic presidential nominee Hillary Clinton and U.S. Republican presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S. October 9, 2016. REUTERS/Brian Snyder
Democratic U.S. presidential nominee Hillary Clinton makes her opening remarks at the start of the second U.S. presidential town hall debate between Clinton and Republican U.S. presidential nominee Donald Trump at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton take the stage at the start of their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Bourg
Republican U.S. presidential nominee Donald Trump and Democratic U.S. presidential nominee Hillary Clinton shake hands at the end of their presidential town hall debate at Washington University in St. Louis, Missouri, U.S., October 9, 2016. REUTERS/Jim Young TPX IMAGES OF THE DAY
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"I didn't in the first debate, and I'm trying not to in this debate," Clinton said.

"And get off this question," Trump said.

Clinton then knocked the real-estate mogul over the fallout from the release of a video on Friday of Trump boasting about grabbing and kissing women without their consent.

RELATED: During the Presidential debates, are you interested in seeing... Debate moderators challenging candidates if they say things that are not true?

"I know you're into big diversion tonight, anything to avoid talking about your campaign and the way it's exploding and the way Republicans are leaving you, but let's at least focus on the issues that some people care about," Clinton said.

When Cooper attempted to turn to a question from an audience member, the real-estate mogul cut in.

"I'd like to know, Anderson, why aren't you bringing up the emails?" Trump said.

RELATED: See the GOP congressmen who've come out against Trump

23 PHOTOS
30 former GOP congressmen come out against Trump
See Gallery
30 former GOP congressmen come out against Trump

Bob Bauman (R-MD)

(Photo via US Government/Wikipedia)

Steve Bartlett (R-TX)

(Photo via US Government/Wikipedia)

Sherwood Boehlert (R-NY)

(Photo by Chris Kleponis/Bloomberg via Getty Images)

Jack Buechner (R-MO)

(Photo via US Government/Wikipedia)

Tom Campbell (R-CA)

(Photo by Douglas Graham/Congressional Quarterly/Getty Images)

Bill Clinger (R-PA)

(Photo via US Government/Wikipedia)

Tom Coleman (R-MO)

(Photo via US Government/Wikipedia)

Geoff Davis (R-KY)

(Photo By Bill Clark/Roll Call via Getty Images)

Mickey Edwards (R-OK)

(Photo via US Government/Wikipedia)

Harris Fawell (R-IL)

(Photo via US Government/Wikipedia)

Ed Foreman (R-TX) (R-NM)

(Photo via US Government/Wikipedia)

Amo Houghton, Jr. (R-NY)

(Photo via US Government/Wikipedia)

Jim Leach (R-IA) 

(Photo by Matthew Staver/Bloomberg via Getty Images)

Connie Morella (R-MD)

(Photo by Susan Biddle/The Washington Post/Getty Images)

John Porter (R-IL)

(Photo by Scott J. Ferrell/Congressional Quarterly/Getty Images)

Claudine Schneider (R-RI)

(Photo via US Government/Wikipedia)

John "Joe" Schwarz (R-MI)

(Photo via US Government/Wikipedia)

Chris Shays (R-CT)

(Photo By Tom Williams/CQ Roll Call)

Peter Smith (R-VT)

(Photo via US Government/Wikipedia)

Edward Weber (R-OH)

(Photo via US Government/Wikipedia)

Vin Weber (R-MN)

(Photo by Joshua Roberts/Bloomberg via Getty Images)

G. William Whitehurst (R-VA)

(Photo via US Government/Wikipedia)

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"We brought up the emails," Cooper responded.

"No it hasn't, it hasn't, and it hasn't been finished," Trump said.

As he walked back toward his stool, the Republican presidential nominee got in one final barb.

"It's nice to — one-on-three," Trump said, referencing the moderators.

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