Ellen Pompeo is opening up about the relationships she has with her co-stars.
During her guest appearance on Jada Pinkett Smith's Red Table Talk Facebook Watch series, the 49-year-old actress revealed that she hasn't spoken to her former onscreen lover, Patrick Dempsey, since his Grey's Anatomy exit in 2015.
"We haven't spoken since he's left the show," said Pompeo, who portrays Dr. Meredith Grey on the popular ABC series. "I have no hard feelings toward him. He's a wonderful actor, and we made the best TV you can make together."
"That's a talented man right there. He did 11 amazing years," she continued. "Typically, when people leave the show, they need to sort of find themselves, who they are without the show, because the show takes up so much of your life. You need that time to figure out who you are without the show, so, we have not spoken, but I will always have a place in my heart for Patrick."
When ET exclusively spoke with Dempsey in October, he had nothing but amazing things to say about Pompeo and the rest of the Grey's cast.
"That was a very special bond that just -- there was a magic to our connection and that's special," he gushed. "I think it started with the original cast and the length that it has and the new people that have come in, and it's amazing and it's continuing to affect so many people and to really be a strong part of so many people's lives. You're a part of television history. It's really remarkable."
Pompeo was also a guest on The Ellen DeGeneres Show in October, where she got emotional while reflecting on the impact of Grey's Anatomy.
"Everywhere I go -- whether it's Italy, whether it's France, London, Kansas -- people come up to me with tears in their eyes and tell me how meaningful it is to them," Pompeo said, adding that fans can expect a 16th season because "there's just no end in sight" for the medical drama. "So I gotta keep doing it, man. Because we're touching lives and making a difference."
Ellen Pompeo through the years
Ellen Pompeo through the years
Ellen Pompeo during 'Catch Me If You Can' Los Angeles Premiere at Mann Village Theatre in Westwood, California, United States. (Photo by Jim Smeal/WireImage)
Ellen Pompeo during 2002 Toronto Film Festival - Motorola 'Moonlight Mile' Party at Power Plant in Toronto, Ontario, Canada. (Photo by J. Vespa/WireImage)
Ellen Pompeo (Photo by George Pimentel/WireImage)
Actress Ellen Pompeo stars in the fall movie 'Moonlight Mile' with Jake Guylenhall, Dustin Hoffman and Susan Sarandon. Here she is photographed in Wattles Garden Park. 08/23/2002 (Photo by Anne Cusack/Los Angeles Times via Getty Images)
Ellen Pompeo (Photo by Jean-Paul Aussenard/WireImage)
Ellen Pompeo during DreamWorks Premiere of Old School - Arrivals at Grauman's Chinese Theatre in Hollywood, CA, United States. (Photo by Jeff Kravitz/FilmMagic, Inc)
Ellen Pompeo at the The Beverly Hilton Hotel in Beverly Hills, California (Photo by Lester Cohen/WireImage)
Ellen Pompeo during 'Collateral' Los Angeles Premiere - Arrivals at Orpheum Theatre in Los Angeles, California, United States. (Photo by Jeffrey Mayer/WireImage)
Ellen Pompeo during Prada Opens Beverly Hills Epicenter - Arrivals at Rodeo Drive in Beverly Hills, California, United States. (Photo by Jean-Paul Aussenard/WireImage)
Ellen Pompeo during 57th Annual Primetime Emmy Awards - Arrivals at The Shrine in Los Angeles, California, United States. (Photo by Jon Kopaloff/FilmMagic)
Patrick Dempsey and Ellen Pompeo during 57th Annual Primetime Emmy Awards - Press Room at The Shrine in Los Angeles, California, United States. (Photo by Jon Kopaloff/FilmMagic)
Ellen Pompeo (Photo by Gail Oskin/WireImage for PMK/HBH)
Ellen Pompeo wearing Gucci 2562S Sunglasses (Photo by Djamilla Rosa Cochran/WireImage)
Ellen Pompeo during 'Chanel' Costume Institute Gala at The Metropolitan Museum of Art - Arrivals at The Metropolitan Museum of Art in New York City, New York, United States. (Photo by James Devaney/WireImage)
Ellen Pompeo during Opening of the Billy Wilder Theater at the Hammer Museum at Billy Wilder Theater at the Hammer Museum in Westwood, California, United States. (Photo by Jon Kopaloff/FilmMagic)
Ellen Pompeo at the Social Hollywood in Hollywood, California (Photo by Steve Granitz/WireImage)
Ellen Pompeo during 58th Annual Primetime Emmy Awards - Arrivals at Shrine Auditorium in Los Angeles, California, United States. (Photo by Jon Kopaloff/FilmMagic)
NEW YORK - FEBRUARY 06: Actress Ellen Pompeo arrives at the Madonna and Gucci Host 'A Night to Benefit Raising Malawi and UNICEF' at the United Nations on February 6, 2007 in New York City. (Photo by Kevin Mazur/WireImage)
LOS ANGELES, CA - JANUARY 09: Actress Ellen Pompeo arrives for the 34th Annual People's Choice Awards - Arrivals held at Nokia Theater at L.A. Live on January 9, 2013 in Los Angeles, California. (Photo by Albert L. Ortega/Getty Images)
Actress Ellen Pompeo attends the grand opening of Marquee Nightclub at Marquee Nightclub In The Cosmopolitan on December 30, 2010 in Las Vegas, Nevada.
GREY'S ANATOMY - 'It's Alright, Ma (I'm Only Bleeding)' - Miranda continues to deal with the aftermath of Ben's reckless decisions and forms an advisory committee to recommend proper disciplinary action against him. Meanwhile, April and Jackson try to put their differences aside for the sake of their baby, and Arizona makes a decision that could affect her relationship with Callie forever, on 'Grey's Anatomy,' THURSDAY, APRIL 14 (9:00-10:00 p.m. EDT) on the ABC Television Network. (Photo by Mitch Haaseth/ABC via via Getty Images)ELLEN POMPEO
GREY'S ANATOMY - 'The End is the Beginning is the End' - Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark Sloane's old patients. Meanwhile, Derek begins recovery on his hand, on 'Grey's Anatomy,' THURSDAY, JANUARY 17 (9:00-10:02 p.m., ET) on the ABC Television Network. (Photo by Danny Feld/ABC via Getty Images)
ELLEN POMPEO, SARAH DREW, SANDRA OH
PACIFIC PALISADES, CA - OCTOBER 06: Ellen Pompeo arrives at the 3rd Annual Veuve Clicquot Polo Classic held at Will Rogers State Historic Park on October 6, 2012 in Pacific Palisades, California. (Photo by Michael Tran/FilmMagic)
BEVERLY HILLS, CA - DECEMBER 11: Actress Ellen Pompeo arrives at Rihanna's First Annual Diamond Ball at The Vineyard on December 11, 2014 in Beverly Hills, California. (Photo by Barry King/FilmMagic)
LOS ANGELES, CA - NOVEMBER 05: Ellen Pompeo attends a private dinner hosted by VOGUE to celebrate TOD'S Creative Director Alessandra Facchinetti on November 5, 2014 in Los Angeles, California. (Photo by Donato Sardella/Getty Images for TOD'S)
WEST HOLLYWOOD, CA - SEPTEMBER 22: Actress Ellen Pompeo attends the 'Welcome to the Age of Cool' event hosted by Philosophy and Ellen Pompeo on September 22, 2016 in West Hollywood, California. (Photo by Allen Berezovsky/Getty Images)
LOS ANGELES, CA - DECEMBER 03: Actress Ellen Pompeo attends a basketball game between the Los Angeles Lakers and the Houston Rockets at Staples Center on December 3, 2017 in Los Angeles, California. (Photo by Allen Berezovsky/Getty Images)
NEW YORK, NY - NOVEMBER 09: Actress Ellen Pompeo is seen outside 'Good Morning America' on November 9, 2017 in New York City. (Photo by Raymond Hall/GC Images)