The 49-year-old actress appears on Thursday’s episode of The Ellen DeGeneres Show where she opens up about visiting the Clooney family while filming her new Adam Sandler film, Murder Mystery, in Lake Cuomo, Italy.
“The Clooneys, so sweet,” Aniston says when asked about seeing George, Amal, and their 1-year-old twins, Alexander and Ella.
"Is it weird to see him with children now?” host DeGeneres asks.
"It’s amazing to see him with children,” Aniston notes. "That’s what we talked about that anything can happen.”
Though the actress loves to see George's new family, she’s not exactly up to date on all of the twins’ milestones.
When asked how old they were, she sheepishly replies, "I don’t know. Maybe a little over a year?”
The kiddos are in fact about a year and a half old.
George, who once appeared in an episode of Aniston's show, Friends, as Dr. Doug Ross from ER, opened up to ET around Halloween about how his life has changed since becoming a father of two. He even missed the first night of the Casamigos festivities, which his business partner, Rande Gerber, and wife Cindy Crawford attended.
“Last night they were dressed up as rock stars, and I was dressed up as a guy cleaning crap out of a baby’s diaper,” he joked to ET. “It was a fantastic costume. Oh, so much fun. You could imagine the fun I had last night.”
Jennifer Aniston through the years
Jennifer Aniston through the years
FERRIS BUELLER -- Pictured: Jennifer Aniston as Jeannie Bueller -- Photo by: Alice S. Hall/NBC/NBCU Photo Bank
1990 file photo of Jennifer Aniston at a NBC pool party in Los Angeles, California (Photo by Barry King/WireImage)
FRIENDS -- Pictured: Jennifer Aniston as Rachel Green -- (Photo by Reisig & Taylor/NBC/NBCU Photo Bank via Getty Images)
FRIENDS -- Season 1 -- Pictured: (back l-r) Matt LeBlanc as Joey Tribbiani, Lisa Kudrow as Phoebe Buffay, David Schwimmer as Ross Geller, Matthew Perry as Chandler Bing (front l-r) Courteney Cox as Monica Geller, Jennifer Aniston as Rachel Green -- (Photo by Reisig & Taylor/NBC/NBCU Photo Bank via Getty Images)
FRIENDS -- Pictured: (l-r) Courteney Cox as Monica Geller, Jennifer Aniston as Rachel Green, Lisa Kudrow as Phoebe Buffay in 'Friends', circa 1995. (Photo by NBC/NBCU Photo Bank via Getty Images)
255721 02: Jennifer Aniston poses January 4, 1996 in Aspen, CO. Along with her role as Rachel on the television show 'Friends,' actress Aniston starred in the films 'Picture Perfect' and 'She's The One.' (Photo by Russell Turiak/Liaison)
1997 Jennifer Aniston Stars In The Movie 'Til There Was You'. (Photo By Getty Images)
FRIENDS -- Season 4 -- Pictured: (l-r) Matt LeBlanc as Joey Tribbiani, Jennifer Aniston as Rachel Green, Lisa Kudrow as Phoebe Buffay (Photo by Gerald Weinman/NBC/NBCU Photo Bank via Getty Images)
UNITED STATES - NOVEMBER 03: Jennifer Aniston arrives for premiere of movie 'Meet Joe Black' at the Ziegfeld Theater. (Photo by Richard Corkery/NY Daily News Archive via Getty Images)
372882 01: Jennifer Aniston stars in 'Friends,' 1999-2000 season. Photo by: Warner Bros. NBC
Co-hosts Courteney Cox Arquette, Lisa Kudrow and Jennifer Aniston at 'The 10th Annual Fire & Ice Ball', a gala event, hosted by Lilly Tartikoff and Ronald O. Perelman, to raise funds for Revlon/UCLA women's cancer research program. 12/11/00 at the Beverly Hilton Hotel in Los Angeles, Ca. (Photo by Kevin Winter/Getty Images)
PASADENA, : Actress Jennifer Aniston of the television show 'Friends' accepts her People's Choice Award for 'Favorite Female Television Performer' during the 27th Annual People's Choice Awards 07 January 2001 in Pasadena CA. AFP Photo Lucy NICHOLSON/ (Photo credit should read LUCY NICHOLSON/AFP/Getty Images)
Jennifer Aniston on 'The Tonight Show with Jay Leno' at the NBC Studios in Burbank, Ca. 9/5/01. Los Angeles. Photo by Kevin Winter/Getty Images.
Jennifer Aniston during The 54th Annual Primetime Emmy Awards - Press Room at The Shrine Auditorium in Los Angeles, California, United States. (Photo by Gregg DeGuire/WireImage)
Jennifer Aniston (Photo by J. Merritt/FilmMagic)
Jennifer Aniston and Brad Pitt during 'Along Came Polly' Los Angeles Premiere at Mann's Chinese Theater in Hollywood, California, United States. (Photo by Jon Kopaloff/FilmMagic)
Jennifer Aniston during 9th Annual Hollywood Film Festival Awards Gala Ceremony - Show at Beverly Hilton in Los Angeles, California, United States. (Photo by J.Sciulli/WireImage)
Jennifer Aniston, presenter (Photo by Jeff Kravitz/FilmMagic)
LOS ANGELES, CA - DECEMBER 09: Actress Jennifer Aniston arrives at the premiere screening of the FX Network's 'Dirt' at the Paramount Theater on December 9, 2006 in Los Angeles, California. (Photo by Charley Gallay/Getty Images)
NEW YORK - DECEMBER 17: Jennifer Aniston visits the ''Late Show with David Letterman'' at the Ed Sullivan Theater on December 17, 2008 in New York City. (Photo by James Devaney/WireImage)
MARRAKECH, MOROCCO - NOVEMBER 26: Actress Jennifer Aniston attends the Gala evening to celebrate the re-opening of Hotel La Mamounia on November 26, 2009 in Marrakech, Morocco. (Photo by Fizcairn/WireImage)
NEW YORK - MARCH 16: Jennifer Aniston attends the premiere of 'The Bounty Hunter' at Ziegfeld Theatre on March 16, 2010 in New York, New York City. (Photo by James Devaney/WireImage)
LATE NIGHT WITH JIMMY FALLON -- Episode 876 -- Pictured: (l-r) Jennifer Aniston with host Jimmy Fallon during an interview on August 1, 2013 -- (Photo by: Lloyd Bishop/NBC/NBCU Photo Bank via Getty Images)
MADRID, SPAIN - FEBRUARY 22: Actress Jennifer Aniston attends 'El Hormiguero' Tv showon February 22, 2011 in Madrid, Spain. (Photo by Juan Naharro Gimenez/Getty Images)
Actress Jennifer Aniston arrives at the 'Horrible Bosses' Los Angeles premiere at Grauman's Chinese Theatre on June 30, 2011 in Hollywood, California.
LOS ANGELES, CA - OCTOBER 17: Jennifer Aniston arrives as ELLE Honors Hollywood+s Most Esteemed Women in the 18th Annual Women in Hollywood Tribute; at The Four Seasons Beverly Hills on October 17, 2011 in Los Angeles, California. (Photo by Gregg DeGuire/FilmMagic)
BEVERLY HILLS, CA - NOVEMBER 15: Justin Theroux and Jennifer Aniston attend the American Cinematheque 26th annual award presentation at The Beverly Hilton Hotel on November 15, 2012 in Beverly Hills, California. (Photo by Jason LaVeris/FilmMagic)
TORONTO, ON - SEPTEMBER 14: Actress/producer Jennifer Aniston arrives at the 'Life Of Crime' Premiere during the 2013 Toronto International Film Festival at Roy Thomson Hall on September 14, 2013 in Toronto, Canada. (Photo by Isaiah Trickey/FilmMagic)
HOLLYWOOD, CA - NOVEMBER 21: Actress Jennifer Aniston speaks onstage during a Q&A following the screening of 'Cake' during the 2014 Variety Screening Series at ArcLight Hollywood on November 21, 2014 in Hollywood, California. (Photo by Imeh Akpanudosen/Getty Images)
LOS ANGELES, CA - AUGUST 19: Jennifer Aniston arrives at the Premiere Of Lionsgate Premiere's 'She's Funny That Way' at Harmony Gold on August 19, 2015 in Los Angeles, California. (Photo by Steve Granitz/WireImage)
SANTA MONICA, CA - JANUARY 17: Actress Jennifer Aniston arrives at the 21st Annual Critics' Choice Awards at Barker Hangar on January 17, 2016 in Santa Monica, California. (Photo by C Flanigan/Getty Images)
HOLLYWOOD, CA - APRIL 13: Actress Jennifer Aniston attends Open Roads World Premiere of 'Mother's Day' at TCL Chinese Theatre IMAX on April 13, 2016 in Hollywood, California. (Photo by Frederick M. Brown/Getty Images)
NEW YORK, NY - JUNE 16: Actress Jennifer Aniston is seen walking in Soho on June 16, 2016 in New York City. (Photo by Raymond Hall/GC Images)
NEW YORK, NY - JUNE 24: Jennifer Aniston seen on the streets of Manhattan on June 24, 2016 in New York City. (Photo by James Devaney/GC Images)
NEW YORK, NY - SEPTEMBER 30: Jennifer Aniston is seen in the West Village on September 30, 2016 in New York City. (Photo by Alo Ceballos/GC Images)
WESTWOOD, CA - DECEMBER 07: Actress Jennifer Aniston arrives at the Los Angeles Premiere 'Office Christmas Party' at Regency Village Theatre on December 7, 2016 in Westwood, California. (Photo by Jon Kopaloff/FilmMagic)
LOS ANGELES, CA - DECEMBER 08: Jennifer Aniston is seen at 'Jimmy Kimmel Live' on December 08, 2016 in Los Angeles, California. (Photo by RB/Bauer-Griffin/GC Images)
US actress Jennifer Aniston addresses the audience at the 89th Oscars on February 26, 2017 in Hollywood, California. / AFP / Mark RALSTON (Photo credit should read MARK RALSTON/AFP/Getty Images)
LOS ANGELES, CA - APRIL 04: Jennifer Aniston attends the premiere of HBO's 'The Leftovers' Season 3 at Avalon Hollywood on April 4, 2017 in Los Angeles, California. (Photo by JB Lacroix/WireImage)
US actress Jennifer Aniston gestures as she poses during a photocall ahead of a diner for the launch of a Louis Vuitton leather goods collection in collaboration with US artist Jeff Koons, at the Louvre in Paris on April 11, 2017. / AFP PHOTO / GABRIEL BOUYS (Photo credit should read GABRIEL BOUYS/AFP/Getty Images)
PARIS, FRANCE - APRIL 14: Actress Jennifer Aniston is seen leaving the 'Dries Van Noten' store on April 14, 2017 in Paris, France. (Photo by Marc Piasecki/GC Images)
Actor Jennifer Aniston (L) and Justin Theroux attend Jason Bateman's star unveiling ceremony on the Hollywood Walk of Fame, on July 26, 2017, in Hollywood, California. / AFP PHOTO / VALERIE MACON (Photo credit should read VALERIE MACON/AFP/Getty Images)
BEVERLY HILLS, CA - JANUARY 07: In this handout photo provided by NBCUniversal, Presenters Carol Burnett and Jennifer Aniston onstage during the 75th Annual Golden Globe Awards at The Beverly Hilton Hotel on January 7, 2018 in Beverly Hills, California. (Photo by Paul Drinkwater/NBCUniversal via Getty Images)