Robert De Niro and wife Grace Hightower split after 21 years of marriage

Robert De Niro and Grace Hightower are calling it quits. 

The couple has split after 21 years of marriage, ET has learned. De Niro and Hightower share two children: son Elliot, born in 1998, and daughter Helen, born in 2011. 

This isn't the first time De Niro and Hightower have broken up. They married in 1997, but split briefly in 1999, though never finalized their divorce. In 2004, they renewed their vows. 

De Niro and Hightower, who met in 1987, have been pretty private about their relationship over the years. But in a 2013 interview with CBS News, the actor couldn't help but gush about his family, and his then-1-year-old daughter, Helen. 

"She's so adorable. You just look at her, and it's all there. There's nothing... nothing else matters," he said. 

25 PHOTOS
Robert DeNiro and Grace Hightower together
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Robert DeNiro and Grace Hightower together
NEW YORK, NY - JUNE 10: Grace Hightower and Robert De Niro pose backstage during the 72nd Annual Tony Awards at Radio City Music Hall on June 10, 2018 in New York City. (Photo by Kevin Mazur/Getty Images for Tony Awards Productions)
NEW YORK, NY - APRIL 30: Actor Robert De Niro (L) and Grace Hightower attend the 45th Chaplin Award Gala at the Alice Tully Hall on April 30, 2018 in New York City. (Photo by Jamie McCarthy/Getty Images)
NEW YORK, NY - APRIL 28: Robert De Niro and Grace Hightower attend the premiere of 'The Fourth Estate' during the 2018 Tribeca Film Festival at Borough of Manhattan Community College on April 28, 2018 in New York City. (Photo by Taylor Hill/FilmMagic)
NEW YORK, NY - APRIL 23: Grace Hightower and Robert De Niro attend the 13th Annual Tribeca Film Festival CHANEL Dinner at Balthazar on April 23, 2018 in New York City. (Photo by Taylor Hill/FilmMagic)
NEW YORK, NY - MAY 08: Robert De Niro (L) and Grace Hightower attend the 44th Chaplin Award Gala at David H. Koch Theater at Lincoln Center on May 8, 2017 in New York City. (Photo by Dia Dipasupil/WireImage)
NEW YORK, NY - MAY 08: Actor Robert De Niro (L) and Grace Hightower attend the 44th Chaplin Award Gala at David H. Koch Theater at Lincoln Center on May 8, 2017 in New York City. (Photo by Dia Dipasupil/Getty Images)
NEW YORK, NY - APRIL 20: Grace Hightower and Robert De Niro attend the 2017 IWC Schaffhausen 'For The Love Of Cinema' Gala Dinner at Spring Studios on April 20, 2017 in New York City. (Photo by Rabbani and Solimene Photography/Getty Images)
NEW YORK, NY - APRIL 20: Grace Hightower and Robert De Niro attend the 2017 IWC Schaffhausen 'For The Love Of Cinema' Gala Dinner at Spring Studios on April 20, 2017 in New York City. (Photo by Rabbani and Solimene Photography/Getty Images)
NEW YORK, NY - APRIL 19: Grace Hightower and Robert De Niro attend the 'Clive Davis: The Soundtrack of Our Lives' 2017 Opening Gala of the Tribeca Film Festival at Radio City Music Hall on April 19, 2017 in New York City. (Photo by Taylor Hill/Getty Images)
NEW YORK, NY - DECEMBER 01: Grace Hightower and Robert De Niro attends the Broadway Opening Night Perfomance of 'A Bronx Tale' at The Longacre on December 1, 2016 in New York City. (Photo by Walter McBride/WireImage)
NEW YORK, NY - AUGUST 22: Grace Hightower and Robert De Niro attend the 'Hands of Stone' U.S. premiere at SVA Theater on August 22, 2016 in New York City. (Photo by Andrew Toth/FilmMagic)
NEW YORK, NY - AUGUST 22: Grace Hightower (L) and Robert De Niro attend the New York Premiere Of 'Hands Of Stone' in Partnership with DeLeon Tequila, NetJets, The Redbury New York and VisitPanama at SVA Theater on August 22, 2016 in New York City. (Photo by Jason Kempin/Getty Images for The Weinstein Company)
NEW YORK, NY - MAY 18: Robert DeNiro and Grace Hightower attend Riverkeeper's 50th Anniversary Fishermen's Ball at Pier Sixty at Chelsea Piers on May 18, 2016 in New York City. (Photo by Laura Cavanaugh/FilmMagic)
CAP D'ANTIBES, FRANCE - MAY 17: Robert DeNiro (L) and Grace Hightower attend the De Grisogono Party at the annual 69th Cannes Film Festival at Hotel du Cap-Eden-Roc on May 17, 2016 in Cap d'Antibes, France. (Photo by Anthony Ghnassia/Getty Images)
CANNES, FRANCE - MAY 16: Boxer Roberto Duran, Robert de Niro and his wife Grace Hightower, Edgar Ramirez and Anna de Armas leave the 'Hands Of Stone' premiere during the 69th annual Cannes Film Festival at the Palais des Festivals on May 16, 2016 in Cannes, France. (Photo by Gisela Schober/Getty Images)
CANNES, FRANCE - MAY 16: Robert de Niro and his wife Grace Hightower leave the 'Hands Of Stone' premiere during the 69th annual Cannes Film Festival at the Palais des Festivals on May 16, 2016 in Cannes, France. (Photo by Gisela Schober/Getty Images)
CANNES, FRANCE - MAY 16: Robert de Niro and his wife Grace Hightower attend the 'Hands Of Stone' Premiere during the annual 69th Cannes Film Festival at Palais des Festivals on May 16, 2016 in Cannes, France. (Photo by Foc Kan/FilmMagic)
CANNES, FRANCE - MAY 16: (L to R) US actor Robert De Niro, Grace Hightower De Niro and Venezuelan actor Edgar Ramirez arrive for the screening of the film 'Hands of Stone' at the 69th annual Cannes Film Festival in Cannes on May 16, 2016. (Photo by Mustafa Yalcin/Anadolu Agency/Getty Images)
Robert De Niro, izquierda, y Grace Hightower asisten a una función especial de "Goodfellas" en el Beacon Theater, 25 de abril de 2015, con la cual finalizó el festival de cine de Tribeca. (Foto de Andy Kropa/Invision/AP)
Actor-director Robert De Niro and his wife Grace Hightower attend the 20th anniversary screening of "A Bronx Tale" presented by First Time Fest and Tribeca Film Institute on Monday, Feb. 24, 2014 in New York. (Photo by Evan Agostini/Invision/AP)
Robert De Niro attends "The King Of Comedy" screening with his wife Grace Hightower on Saturday, April 27, 2013 in New York. De Niro stars in the 1982 film with Jerry Lewis and Sandra Bernhard. (Photo by Dario Cantatore/Invision/AP )
Jury president Robert De Niro and his wife Grace Hightower arrive for the screening of Pirates of the Caribbean: On Stranger Tides, at the 64th international film festival, in Cannes, southern France, Saturday, May 14, 2011. (AP Photo/Joel Ryan)
Tribeca Film Festival co-founder Robert De Niro arrives with his wife, Grace Hightower, for the premiere of the new movie " The Interpreter" at the opening night of the festival, Tuesday, April 19, 2005, in New York. (AP Photo/ Louis Lanzano)
U.S. actor Robert De Niro, right, accompanied by his wife Grace Hightower, arrives at Rome's Auditorium, Saturday, Oct. 21, 2006, for a meeting with the audience at the first ever edition of the Rome Film Festival. (AP Photo/Andrew Medichini)
Robert De Niro, left, and Grace Hightower arrive at the premiere of "Stardust" in Los Angeles on Sunday, July 29, 2007. (AP Photo/Matt Sayles)
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The next year, Hightower told the Wall Street Journal what she had learned from her husband about business.

"Patience, really being, patience not panic, looking at all angles when starting up a business, always thinking there's a way to do this. There's another way to succeed at this," she said. 

De Niro was previously married to Diahnne Abbott, from 1976 to 1988. He shares son Raphael with Abbott, and twin sons Aaron and Julian with his former girlfriend, Toukie Smith. 

28 PHOTOS
Robert De Niro
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Robert De Niro
American actor Robert de Niro on the set of Once Upon a Time in America, directed by Sergio Leone. (Photo by Sunset Boulevard/Corbis via Getty Images)
American actor Robert de Niro on the set of Once Upon a Time in America, directed by Sergio Leone. (Photo by Sunset Boulevard/Corbis via Getty Images)
Robert De Niro as Vito Corleone in the 1974 film The Godfather: Part II. (Photo by �� John Springer Collection/CORBIS/Corbis via Getty Images)
American actor Robert de Niro on the set of Taxi Driver, directed by Martin Scorsese. (Photo by Sunset Boulevard/Corbis via Getty Images)
American actor Robert de Niro on the set of Mean Streets, written and directed by Martin Scorsese. (Photo by Sunset Boulevard/Corbis via Getty Images)
Robert De Niro in Taxi Driver (Photo by Herbert Dorfman/Corbis via Getty Images)
Robert De Niro during 2003 Tribeca Film Festival - 'Chinese Coffee' Screening at Tribeca Performing Arts Center in New York, New York, United States. (Photo by J. Vespa/WireImage)
NEW YORK, NY - FEBRUARY 15: Robert De Niro (R) and Grace Hightower attend the SNL 40th Anniversary Celebration at Rockefeller Plaza on February 15, 2015 in New York City. (Photo by D Dipasupil/FilmMagic)
NEW YORK, NY - DECEMBER 16: Robert De Niro attends the 2014 Robert F. Kennedy Ripple Of Hope Gala at New York Hilton on December 16, 2014 in New York City. (Photo by Taylor Hill/Getty Images)
NEW YORK, NY - DECEMBER 16: Honoree Robert De Niro speaks onstage during the RFK Ripple Of Hope Gala at Hilton Hotel Midtown on December 16, 2014 in New York City. (Photo by Mike Coppola/Getty Images for RFK Ripple Of Hope)
ROME, ITALY - NOVEMBER 17: Robert De Niro attends the Remembering The Artist Robert De Niro Conference at Maxxi Museum on November 17, 2014 in Rome, Italy. (Photo by Ernesto Ruscio/Getty Images)
ROME, ITALY - NOVEMBER 17: Robert De Niro attends the Remembering The Artist Robert De Niro Press Conference at Maxxi Museum on November 17, 2014 in Rome, Italy. (Photo by Ernesto Ruscio/Getty Images)
NEW YORK, NY - OCTOBER 28: Actor Robert DeNiro is seen on October 28, 2014 in New York City. (Photo by NCP/Star Max/GC Images)
NEW YORK NY - OCTOBER 18: Robert De Niro sighting on October 18, 2014 in New York City. (Photo by Josiah Kamau/BuzzFoto/FilmMagic)
NEW YORK, NY - SEPTEMBER 27: 'Once Upon A Time In America' cast member Robert De Niro attends the 52nd New York Film Festival at Walter Reade Theater on September 27, 2014 in New York City. (Photo by Slaven Vlasic/Getty Images)
NEW YORK, NY - SEPTEMBER 21: Robert De Niro attends 2014 Atlantic Council's Global Citizen Awards at Natural History Museum on September 21, 2014 in New York City. (Photo by Robin Marchant/Getty Images)
NEW YORK, NY - SEPTEMBER 18: Robert DeNiro, Anne Hathaway filming Nancy Meyer's 'The Intern' on September 18, 2014 in New York City. (Photo by Steve Sands/GC Images)
NEW YORK, NY - AUGUST 26: Robert DeNiro and Anne Hathaway film on the set of 'The Intern' on August 26, 2014 in New York City. (Photo by Steve Sands/GC Images)
NEW YORK, NY - JULY 08: Actor Robert De Niro on the set of 'The Intern' on July 8, 2014 in Brooklyn, New York. (Photo by Bobby Bank/GC Images)
NEW YORK, NY - JUNE 26: Ruby Kushner and Robert De Niro on the set of 'The Intern' on June 26, 2014 in New York City. (Photo by Bobby Bank/GC Images)
NEW YORK, NY - JUNE 23: Actors Robert De Niro and Linda Lavin on the set of 'The Intern' on June 23, 2014 in New York City. (Photo by Bobby Bank/GC Images)
NEW YORK, NY - JUNE 23: Actor Robert De Niro on the set of 'The Intern' on June 23, 2014 in New York City. (Photo by Bobby Bank/GC Images)
NEW YORK, NY - JUNE 23: Robert De Niro is seen filming The Intern in Park Slope, Brooklyn on June 23, 2014 in New York City. (Photo by Alessio Botticelli/GC Images)
NEW YORK, NY - MAY 06: Director Martin Scorsese and actor Robert De Niro speak onstage at Spike TV's 'Don Rickles: One Night Only' on May 6, 2014 in New York City. (Photo by Kevin Mazur/Getty Images for Spike TV)
WASHINGTON, DC - MAY 02: Robert De Niro and Grace Hightower attend a screening of the HBO documentary 'Remembering The Artist, Robert De Niro, Sr.' hosted by POLITICO at the Longview Gallery on May 2, 2014 in Washington, DC. (Photo by Alexander Morozov/Getty Images)
Actor Robert De Niro talks to reporters and film professionals during "Coffee with..." event during the 22nd Sarajevo Film Festival in Sarajevo, Bosnia and Herzegovina, August 13, 2016. REUTERS/Dado Ruvic
Paris, France, 24 11 1977, Robert De Niro actor. (Photo by Francis Apesteguy/Getty Images)
UNITED STATES - CIRCA 2000: Robert De Niro is on hand at the Museum of the Moving Image dinner honoring film producer Jane Rosenthal at the St. Regis Hotel. (Photo by Richard Corkery/NY Daily News Archive via Getty Images)
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