Ricki Lake lost her virginity on set of 'Cry Baby' -- but not to co-star Johnny Depp

With Ricki Lake, no topic is off-limits.

The longtime TV personality showed that's truer than ever during an appearance on "Watch What Happens Live," during which host Andy Cohen eagerly asked her about a variety of NSFW subjects.

Never one to beat around the bush himself, Cohen asked Lake point-blank: “Did you lose your virginity on ‘Hairspray’ or ‘Cry-Baby’?” (Lake's big break was her starring role in 1988's "Hairspray," and "Cry Baby," starring Johnny Depp, came not long later in 1990.)

"'Cry Baby,'" Lake confirmed, adding, "Not to Johnny Depp. Another actor, a really handsome actor. He was very kind to me, and I was very large. I was very happy to get it over with ’cause I was almost 21."

Ricki Lake through the years
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Ricki Lake through the years
CHINA BEACH - 'Unquiet Earth' - Airdate: September 20, 1989. (Photo by ABC Photo Archives/ABC via Getty Images) RICKI LAKE
NEW YORK CITY - MAY 2: Actor Michael St. Gerard and actress Ricki Lake the 'Sticky Fingers' Premiere Party on May 2, 1988 at the Public Theater in New York City. (Photo by Ron Galella/WireImage)
Ricki Lake (right) (Photo by Jeff Kravitz/FilmMagic)
From left, American actors Colleen Fitzpatrick, Debbie Harry, Divine (1945 - 1988), and Ricki Lake in a scene from 'Hairspray,' directed by John Waters, 1988. (Photo by New Line Cinema/Courtesy of Getty Images)
CHINA BEACH - 'Unquiet Earth' - Airdate: September 20, 1989. (Photo by ABC Photo Archives/ABC via Getty Images) RICKI LAKE
Ricki Lake and Julie Brown (Photo by Ron Galella, Ltd./WireImage)
Ricki Lake during Poolside Cocktail Party for Kelly Klein's Book, 'Pools' at Beverly Hills Hotel in Beverly Hills, CA, United States. (Photo by Jeff Kravitz/FilmMagic, Inc)
LATE NIGHT WITH CONAN O'BRIEN -- Episode 15 -- Pictured: (l-r) Actress and Talk Show Host Ricki Lake during an interview with host Conan O'Brien on October 1, 1993 -- (Photo by: Lesly Weiner/NBC/NBCU Photo Bank via Getty Images)
Ricki Lake during The Beat Goes On Concert Benefitting LIFEbeat at Beacon Theater in New York City, New York, United States. (Photo by Jim Smeal/WireImage)
Ricki Lake at Club USA, New York, October 7, 1993. (Photo by Steve Eichner/Getty Images)
Ricki Lake during The 12th Annual MTV Video Music Awards at Radio City Music Hall in New York City, New York, United States. (Photo by Ron Galella/WireImage)
THE TONIGHT SHOW WITH JAY LENO -- Episode 1028 -- Pictured: (l-r) TV personality Ricki Lake during an interview with host Jay Leno on November 11, 1996 -- (Photo by: Margaret Norton/NBC/NBCU Photo Bank via Getty Images)
UNITED STATES - NOVEMBER 01: Ricki Lake (Photo by The LIFE Picture Collection/Getty Images)
Ricki Lake and her husband, Rob Sussman, attend the premiere of John Waters' film, Pecker. (Photo by © Steve Azzara/CORBIS/Corbis via Getty Images)
Ricki Lake during 1999 'Kids for Kids' Carnival Elizabeth Glasser Pediatric Aids Foundation Fundraiser at Industria Studio in New York City, New York, United States. (Photo by KMazur/WireImage)
383689 18: Actress Ricki Lake Is The Host Of Her Own Daytime Talk Show 'Ricki Lake' Which Is In National Syndication And Airs On The United Paramount Network. (Photo By Getty Images)
Ricki Lake during 2002 New York Fashion Week - Moet & Chandon Presents Behnaz Sarafpour Fashion Show at Industria Superstudio in New York City, New York, United States. (Photo by Djamilla Rosa Cochran/WireImage)
UNITED STATES - SEPTEMBER 08: Ricki Lake at the 2001 PETA Humanitarian of the Year Awards at the Waldorf Astoria Hotel, NYC 9/8/01 (Photo by Vinnie Zuffante/Getty Images)
Ricki Lake during Great Joy! A Holiday Celebration from Broadway A Benefit for The Actors Fund of America at The New Amsterdam Theater in New York City, New York, United States. (Photo by Bruce Glikas/FilmMagic)
Ricki Lake at the 'Working' The Musical - One Night Only Performance at The Robert Freud Playhouse - UCLA Campus in Westwood, California. (Photo by Michael Tran/FilmMagic)
Ricki Lake during A Night At The Comedy Store To Benefit The EB Medical Research Foundation Sponsored By Kinerase - Inside at Comedy Store in Los Angeles, CA, United States. (Photo by J. Vespa/WireImage for RPMC)
NEW YORK - JANUARY 09: Executive producer Ricki Lake arrives at 'The Business of Being Born' New York Premiere at the IFC Center on January 9, 2007 in New York City (Photo by Dimitrios Kambouris/WireImage)
NEW YORK - DECEMBER 04: TV personality Ricky Lake attends the 2008 NASCAR Sprint Cup Series Champion's party at Marquee on December 4, 2008 in New York City. (Photo by Bennett Raglin/WireImage)
HOLLYWOOD, CA - NOVEMBER 21: Ricki Lake arrives at CNN Heroes: An All-Star Tribute at the Kodak Theater on November 21, 2009 in Hollywood, California. (Photo by Gregg DeGuire/FilmMagic)
WATCH WHAT HAPPENS LIVE -- Episode 667 -- Pictured: Ricki Lake -- (Photo by: Peter Kramer/Bravo/NBCU Photo Bank via Getty Images)
Ricki Lake attends The Trevor Project's 2011 Trevor Live! at The Hollywood Palladium on December 4, 2011 in Los Angeles, California.
HOLLYWOOD, CA - DECEMBER 02: Ricki Lake arrives at The Trevor Project's 2012 'Trevor Live' Event Honoring Katy Perry at Hollywood Palladium on December 2, 2012 in Hollywood, California. (Photo by C Flanigan/FilmMagic)
HOLLYWOOD, CA - DECEMBER 08: Actress Ricki Lake arrives at the TevorLIVE Los Angeles Benefit celebrating The Trevor Project's 15th anniversary at the Hollywood Palladium on December 8, 2013 in Hollywood, California. (Photo by Amanda Edwards/WireImage)
SANTA MONICA, CA - MAY 16: Actress/producer Ricki Lake attends 'Breastmilk' Los Angeles Premiere on May 16, 2014 in Santa Monica, California. (Photo by Rich Polk/Getty Images for CAVU Pictures)
HOLLYWOOD, CA - NOVEMBER 05: TV Personality Ricki Lake attends the 6th annual 'Stand Up For Pits' at The Hollywood Improv on November 5, 2016 in Hollywood, California. (Photo by Paul Archuleta/Getty Images,)
HAIRSPRAY LIVE! -- 'FYC Panel Discussion and Reception' -- Pictured: Ricki Lake at the Saban Media Center at the Television Academy, North Hollywood, CA -- (Photo by: Trae Patton/NBC)
BEVERLY HILLS, CA - JULY 23: Ricki Lake attends The Academy Presents 'Hairspray' (1988) 30th Anniversary at Samuel Goldwyn Theater on July 23, 2018 in Beverly Hills, California. (Photo by Jon Kopaloff/FilmMagic)

"You were a big gal, and this guy made you feel..." Cohen continued.

"He was really sweet, yeah," Lake said. "My first time was really a good one."

Also among the revelations explored during Lake's appearance: "I Love Lucy" star Lucille Ball was not super polite when the two encountered each other at the 1989 Oscars.

"She wasn't very nice. 'Salty' is putting it mildly," Lake recalled. "She was just, like, ornery. She didn't do anything directly to me, but she was not happy to be there. She died shortly after that."

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