The 72-year-old actress appears on Thursday's episode of The Ellen DeGeneres Show and confirms that she will not be attending the 33-year-old prince's nuptials.
When DeGeneres points out that she's met the royals on several occasions, Mirren recalls a funny moment she shared with Harry's older brother, Prince William. "I was at an awards thing or something, and William was presenting and he knew that I was in the room and he said, 'I've got to be really, really good because my granny is in the house," she reminisces. "So, he kind of knew who I was."
Mirren portrayed William's grandmother, Queen Elizabeth II, in the 2006 film The Queen, and won an Oscar for her role.
The Leisure Seeker star goes on to praise William and Harry, gushing, "They're both unbelievably charming, very straightforward, very charming, and a great credit to their father, [Prince Charles]."
DeGeneres also inquires as to what Mirren thinks of Netflix's The Crown, which is about the life of Queen Elizabeth and currently stars Claire Foy.
"I think it's incredibly accurate," she says of the series. "I think Claire Foy was brilliant. I sent her an email congratulating her. It was fantastic."
As for whether Mirren would ever consider joining the Crown cast, she insists, "No, because it's wonderful that I [portrayed Queen Elizabeth], it was wonderful that it was a success, but I didn't want [a] headline when I'm knocked over by a bus: 'The Queen Knocked Over by Bus.'"
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Helen Mirren out and about
Helen Mirren out and about
HOLLYWOOD, CA - NOVEMBER 12: Actress Helen Mirren wearing a dress by fashion designer Valentino attends the screening of 'The Leisure Seeker' at AFI FEST 2017 Presented By Audi at the Egyptian Theatre on November 12, 2017 in Hollywood, California. (Photo by Tara Ziemba/FilmMagic)
HOLLYWOOD, CA - NOVEMBER 11: Helen Mirren arrives at the Academy Of Motion Picture Arts And Sciences' 9th Annual Governors Awards at The Ray Dolby Ballroom at Hollywood & Highland Center on November 11, 2017 in Hollywood, California. (Photo by Steve Granitz/WireImage)
COSTA MESA, CA - OCTOBER 30: Helen Mirren attends the Mariinsky Orchestra Concert in honor of Henry Segerstrom and the 50th anniversary of South Coast Plaza on October 30, 2017 in Costa Mesa, California. (Photo by David Crotty/Patrick McMullan via Getty Images)
Helen Mirren walks the runway during the Le Defile L'Oreal Paris show as part of the Paris Fashion Week Womenswear Spring/Summer 2018 at the Champs Elysees Avenue in Paris, France, on October 1, 2017. (Photo by Mehdi Taamallah/NurPhoto via Getty Images)
PARIS, FRANCE - OCTOBER 01: Helen Mirren walks the runway during the Le Defile L'Oreal Paris show as part of the Paris Fashion Week Womenswear Spring/Summer 2018 on October 1, 2017 in Paris, France. (Photo by Dominique Charriau/WireImage)
TORONTO, ON - SEPTEMBER 09: Helen Mirren attends 'In Conversation With...Helen Mirren' during the 2017 Toronto International Film Festival at Glenn Gould Studio at CBC on September 9, 2017 in Toronto, Canada. (Photo by Phillip Faraone/Getty Images)
TORONTO, ON - SEPTEMBER 09: Actress Helen Mirren attends Entertainment Weekly's Must List Party during the Toronto International Film Festival 2017 at the Thompson Hotel on September 9, 2017 in Toronto, Canada. (Photo by Alberto E. Rodriguez/Getty Images for Entertainment Weekly)
VENICE, ITALY - SEPTEMBER 03: Helen Mirren attends the 'The Leisure Seeker' photocall during the 74th Venice Film Festival on September 3, 2017 in Venice, Italy. PHOTOGRAPH BY P. Lehman / Barcroft Images
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VENICE, ITALY - SEPTEMBER 03: Helen Mirren walks the red carpet ahead of the 'The Leisure Seeker (Ella & John)' screening during the 74th Venice Film Festival at Sala Grande on September 3, 2017 in Venice, Italy. (Photo by Ernesto Ruscio/Getty Images)
Actor Donald Sutherland and actress Helen Mirren attend the photocall of the movie 'The Leisure Seeker' (Ella and John) presented in competition at the 74th Venice Film Festival on September 3, 2017 at Venice Lido. / AFP PHOTO / Tiziana FABI (Photo credit should read TIZIANA FABI/AFP/Getty Images)
CANNES, FRANCE - JUNE 21: Dame Helen Mirren attends the Cannes Lions Festival 2017 on June 21, 2017 in Cannes, France. (Photo by Christian Alminana/Getty Images for Cannes Lions)
MONTE-CARLO, MONACO - JUNE 20: Helen Mirren attends the 57th Monte Carlo TV Festival : Closing Ceremony on June 20, 2017 in Monte-Carlo, Monaco. (Photo by Stephane Cardinale - Corbis/Corbis via Getty Images)
MONTE-CARLO, MONACO - JUNE 20: British Actress Helen Mirren poses for a Photocall during the 57th Monte Carlo TV Festival : Day Five, on June 20, 2017 in Monte-Carlo, Monaco. (Photo by Stephane Cardinale - Corbis/Corbis via Getty Images)
LONDON, ENGLAND - JUNE 07: (L to R) Matt Smith and Dame Helen Mirren pose with cast member David Tennant at the West End production of 'Don Juan In Soho' at Wyndhams Theatre on June 7, 2017 in London, England. (Photo by David M Benett/Dave Benett/Getty Images)
NEW YORK, NY - MAY 22: Dame Helen Mirren attends the The Stuttering Association For The Young (SAY) 15th Anniversary Gala at NYU Skirball Center on May 22, 2017 in New York City. (Photo by Paul Zimmerman/WireImage)
LOS ANGELES, CA - MAY 12: Helen Mirren attends the University Of Southern California 134th Commencement Ceremonies at The Shrine Auditorium on May 12, 2017 in Los Angeles, California. (Photo by Jerritt Clark/Getty Images)
SAN JOSE, CA - MAY 05: Actress Helen Mirren, star of the new CBS Films' 'Winchester', poses at 'Winchester' Mystery House on May 5, 2017 in San Jose, California. (Photo by C Flanigan/WireImage)
Actress Helen Mirren attends day two of the Colcoa French Film Festival on April 25, 2017, in Los Angeles, California. / AFP PHOTO / VALERIE MACON (Photo credit should read VALERIE MACON/AFP/Getty Images)
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She adds, "I wanted to kind of get away from that. I like to move forward, not back.
When DeGeneres compliments Mirren for embracing her age, the actress seems to think that she's 73 instead of 72. When the daytime talk show host confirms that she's is in fact 72, Mirren exclaims, "This is fantastic! This is amazing! I just made a whole year. Ellen, thank you."
DeGeneres quips, "You look great, but you're losing it."
While Mirren says has no intention of ever retiring from acting, she does admit that she almost always wants to just "stay at home and watch TV." As for her favorite shows, she's loving HBO's Silicon Valley and Netflix's Stranger Things.