"A lot of what I want to say to you guys, I've said to you when we weren't on camera," Tyler told her fellow panelists during the show. "Because while being out here with you guys and everybody at home has been such a gift for all these years, the treasure of this show is my friendships with you guys. That is something that I could never have expected when I walked through the door here, but I do remember that first day and that first week when I was here how special I felt and how comfortable it felt. I knew that this could be a home, but I never imagined in a million years that it would be this magical of a place."
At this point, all of Tyler's co-hosts — Julie Chen, Sharon Osbourne, Sara Gilbert and Sheryl Underwood — were fighting back tears, some more successfully than others.
See photos of Aisha Tyler:
NEW YORK, NEW YORK - MARCH 20: Aisha Tyler attends the 'Batman V Superman: Dawn Of Justice' New York Premiere at Radio City Music Hall on March 20, 2016 in New York City. (Photo by Nicholas Hunt/FilmMagic)
UNIVERSAL CITY, CA - MARCH 09: Aisha Tyler visits 'Extra' at Universal Studios Hollywood on March 9, 2016 in Universal City, California. (Photo by Noel Vasquez/Getty Images)
SANTA MONICA, CA - FEBRUARY 27: Actress Aisha Tyler arrives for the 2016 Film Independent Spirit Awards held on February 27, 2016 in Santa Monica, California. (Photo by C Flanigan/Getty Images)
LOS ANGELES, CA - FEBRUARY 28: Aisha Tyler attends the Oscars Viewing Party at the Private Residence of Jonas Tahlin, CEO of Absolut Elyx on February 28, 2016 in Los Angeles, California. (Photo by Joshua Blanchard/Getty Images for Absolut Elyx)
SANTA MONICA, CA - FEBRUARY 27: Actresses Aisha Tyler and Retta attend the 2016 Film Independent Spirit Awards private reception on February 27, 2016 in Santa Monica, California. (Photo by Amanda Edwards/WireImage)
SANTA MONICA, CA - FEBRUARY 25: Actress Aisha Tyler arrives at the 2016 Oscar Wilde Awards at Bad Robot on February 25, 2016 in Santa Monica, California.(Photo by Jeffrey Mayer/WireImage)
LOS ANGELES, CA - FEBRUARY 24: Aisha Tyler attends Alfre Woodard's 7th Annual 'Oscar's Sistahs Soiree' Presented By Tanqueray No. TEN And Perennial Sports & Entertainment on February 24, 2016 in Los Angeles, California. (Photo by Todd Williamson/Getty Images for Miss Maglashan Productions)
BEVERLY HILLS, CA - JANUARY 10: Actress Aisha Tyler attends InStyle and Warner Bros. 73rd Annual Golden Globe Awards Post-Party at The Beverly Hilton Hotel on January 10, 2016 in Beverly Hills, California. (Photo by Lester Cohen/WireImage)
LOS ANGELES, CA - JANUARY 06: (L-R) TV personalities Sheryl Underwood, Sara Gilbert, Sharon Osbourne, Aisha Tyler and Julie Chen pose with an award in the press room during the People's Choice Awards 2016 at Microsoft Theater on January 6, 2016 in Los Angeles, California. (Photo by Allen Berezovsky/Getty Images)
NEW YORK, NY - DECEMBER 09: Aisha Tyler and Julie Chen of CBS' 'The Talk' ring the closing bell at the New York Stock Exchange on December 9, 2015 in New York City. (Photo by Grant Lamos IV/Getty Images)
NEW YORK, NY - DECEMBER 07: Aisha Tyler attends 'In The Heart Of The Sea' New York premiere at Frederick P. Rose Hall, Jazz at Lincoln Center on December 7, 2015 in New York City. (Photo by Andrew Toth/FilmMagic)
NEW YORK - DECEMBER 8: The ladies of The Talk Sheryl Underwood, Sara Gilbert, Sharon Osbourne, Aisha Tyler and Julie Chen in the green room of CBS This Morning on Tuesday, Dec. 8, 2015 for the CBS Television Network. (Photo by Heather Wines/CBS via Getty Images)
"Life is a mystery, and it remains a mystery," Tyler continued. "You just wake up everyday trying to do your best work and do the best that you can for your friends and be the best person you can be. But the thing that I'll take with me from this show is how all of you made me ... want to be a better woman and a better friend."
Tyler became an official co-host in 2011 during The Talk's second season, following the departures of Leah Remini, Holly Robinson Peete and Marissa Jaret Winokur. Despite her other commitments — including hosting The CW's Whose Line Is It Anyway? and voicing a character on FX/X's Archer — Tyler has remained at the table ever since.