Watch Nicki Minaj bring out Lil Wayne, David Guetta and Jason Derulo for a four-song medley to open 2017 Billboard Music Awards

Nicki Minaj certainly knows how to create a moment. The multi-talented MC opened the 2017 Billboard Music Awards with a bang, bringing out high-profile guests Lil Wayne ("No Frauds"), David Guetta ("Light My Body Up") and Jason Derulo ("Swalla") for a four-song medley that concluded with a solo run through her recent single "Regret In Your Tears."

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Nicki Minaj performs at 2017 Billboard Music Awards
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Nicki Minaj performs at 2017 Billboard Music Awards

Rapper Nicki Minaj performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

Rapper Nicki Minaj performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

DJ David Guetta (top) and rapper Nicki Minaj perform onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

DJ David Guetta (top) and rapper Nicki Minaj perform onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

DJ David Guetta (top) and rapper Nicki Minaj perform onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

Rapper Nicki Minaj performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

DJ David Guetta (top) and rapper Nicki Minaj perform onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

Rapper Nicki Minaj performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada.

(Photo by Ethan Miller/Getty Images)

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After an introduction that included snippets of previous hits like "Beez in the Trap," "Starships" and "Moment For Life," Minaj ripped into a forceful rendition of her much-discussed Remy Ma diss track "No Frauds," with Weezy on hand to run through his verse. Drake, who is also featured on the song, did not appear (though he watched from the crowd), but Minaj had plenty more guests to come, moving seamlessly into "Light My Body Up" with Guetta manning the boards behind her.

Derulo then emerged, sporting long dreads and a chain over an all-black ensemble, to kick into "Swalla." Minaj, seductive and sexy as always, delivered her verse while gyrating in a chair, but she still had more to come. "Regret In Your Tears," another cut she released in a trilogy earlier this year that also included "Frauds" and the Wayne-assisted "Changed It," rounded out her four-song medley and saw the MC rapping-singing while rising on a pedestal, putting an exclamation point on the superstar-charged opener.

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Inside the 2017 Billboard Music Awards
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Inside the 2017 Billboard Music Awards
LAS VEGAS, NV - MAY 21: Co-hosts Ludacris (L) and Vanessa Hudgens speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Rapper Drake (C) accepts the Top Artist award onstage with songwriters, producers and father Dennis Graham during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Singer Celine Dion performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Recording artist John Legend performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: (EDITORS NOTE: Image has been converted to black and white.) Actor/singer Cher performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Dan Reynolds of Imagine Dragons speaks in tribute to the late Chris Cornell (shown on screen). REUTERS/Mario Anzuoni
LAS VEGAS, NV - MAY 21: Rapper Nicki Minaj performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Recording artists Billy Ray Cyrus (L) and Noah Cyrus attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Music group BTS and singer Halsey (C) attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Miley Cyrus performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Recording artists Drake (L) and DJ Khaled attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Rapper Lil Wayne performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: (EDITORS NOTE: Image has been converted to black and white.) Producer Sean 'Diddy' Combs speaks onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Actors Ed Helms (L) and Kevin Hart speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Jason Derulo (C) performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: (L-R) Musicians Alex Pall of The Chainsmokers, Halsey, and Andrew Taggart of The Chainsmokers accept Top Collaboration for 'Closer' onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Singer Camila Cabello performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Recording artists Desiigner (L) and Drake attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Recording artist Julia Michaels (C) performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Camila Cabello attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Chris Polk/BBMA2017/Getty Images for DCP)
LAS VEGAS, NV - MAY 21: Recording artist Julia Michaels (C) performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Drake attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Chris Polk/BBMA2017/Getty Images for DCP)
LAS VEGAS, NV - MAY 21: Musicians Brian Kelley (L) and Tyler Hubbard of Florida Georgia Line accept Top Country Song for 'H.O.L.Y.' onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Miss America 2017 Savvy Shields (L) and TV personality Rachel Lindsay speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: DJ Khaled (L) and actor Ansel Elgort attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Musicians Andrew Taggart (L) and Alex Pall of The Chainsmokers perform onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Recording artists Blake Shelton (L) and Gwen Stefani attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Recording artist Lorde (L) and Sonja Yelich attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Actress Ashley Tisdale attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: (L-R) Recording artists Brian Kelley of Florida Georgia Line, Andrew Taggart of The Chainsmokers, Tyler Hubbard of Florida Georgia Line, and Alex Pall of The Chainsmokers attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Actor Josh Duhamel attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Julia Michaels performs "Issues". REUTERS/Mario Anzuoni
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - The Chainsmokers perform "Young." REUTERS/Mario Anzuoni
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Miley Cyrus performs "Malibu." REUTERS/Mario Anzuoni
LAS VEGAS, NV - MAY 21: Singer Bebe Rexha (L) and DJ Khaled attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: (L-R) Tori Woodward, recording artists Alex Pall and Andrew Taggart of The Chainsmokers, and Haley Rowe attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: (L-R) Recording artists Billy Ray Cyrus and Noah Cyrus, Tish Cyrus, amd Brandi Cyrus attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Recording artist Lorde peforms onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Sam Hunt performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Actors Alexandra Daddario and Ansel Elgort speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Singer Jason Derulo performs. REUTERS/Mario Anzuoni
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Kate Beckinsale presents Top Male Artist. REUTERS/Mario Anzuoni
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Hosts Ludacris and Vanessa Hudgens. REUTERS/Mario Anzuoni
LAS VEGAS, NV - MAY 21: Recording artists Lil Wayne (L) and Nicki Minaj attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Actor Logan Paul (L) and musician Lindsey Stirling speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Singer Miley Cyrus attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Actor Christopher Jordan Wallace (L) and producer Sean 'Diddy' Combs speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Co-host Vanessa Hudgens attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Lorde performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Co-hosts Vanessa Hudgens and Ludacris speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Singer Sam Hunt performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - BTS accepts the Top Social Artist award. REUTERS/Mario Anzuoni
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Drake accepts the award for Top Billboard 200 Album. REUTERS/Mario Anzuoni
LAS VEGAS, NV - MAY 21: Singer Halsey performs onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Julia Michaels (L) and Laura Marano attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Honoree Cher (R) accepts the Billboard Icon Award from singer Gwen Stefani onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Singers Brian Kelley (L) and Tyler Hubbard of Florida Georgia Line perform onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Singer Celine Dion attends the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Co-hosts Vanessa Hudgens (L) and Ludacris speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Actors Olivia Munn (L) and Josh Duhamel attend the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by John Shearer/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Co-hosts Vanessa Hudgens (L) and Ludacris speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
LAS VEGAS, NV - MAY 21: Prince Michael Jackson speaks onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
2017 Billboard Music Awards ? Show - Las Vegas, Nevada, U.S., 21/05/2017 - Florida Georgia Line and John Legend (R) perform. REUTERS/Mario Anzuoni
LAS VEGAS, NV - MAY 21: Recording artist Gwen Stefani, holding the Icon Award, speaks onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Kevin Mazur/BBMA2017/Getty Images for dcp)
LAS VEGAS, NV - MAY 21: Co-hosts Ludacris (L) and Vanessa Hudgens speak onstage during the 2017 Billboard Music Awards at T-Mobile Arena on May 21, 2017 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images)
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Minaj is nominated for the Billboard Chart Achievement Award Presented by Xfinity, alongside Luke Bryan, The Chainsmokers, The Weeknd and Twenty One Pilots. She's had a busy 2017 already; in addition to the songs she performed to open the show, all of which have been released this year, she's also released the song "Changed It" with Wayne, as well as tracks alongside Gucci Mane ("Make Love"), Major Lazer ("Run Up"), DNCE ("Kissing Strangers") and Katy Perry ("Swish Swish"), with an album thought to be on the way this year.

And in March, Nicki earned herself a piece of history when she passed the legendary Aretha Franklin for most Hot 100 appearances among women in the history of the chart with 76. Franklin (73), Taylor Swift (70), Rihanna (58) and Madonna (57) round out the top five. Check out Minaj's star-studded medley below.

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