'Silence of the Lambs' director Jonathan Demme dies at 73

Jonathan Demme has died at the age of 73.

The famed director, who directed such classics as "The Silence of the Lambs" and "Philadelphia," passed away on Wednesday morning from esophageal cancer and complications from heart disease, IndieWire exclusively reported on Wednesday.

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Demme's condition had reportedly deteriorated as of late. He had originally been treated for the disease in 2010, but it came back in 2015.

See photos of Jonathan Demme:

23 PHOTOS
Jonathan Demme through the years
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Jonathan Demme through the years
BEVERLY HILLS, CA - JULY 22: Director Jonathan Demme (L) and actress Meryl Streep pose at the premiere of Paramounts' 'The Manchurian Candidate' at the Samual Goldwyn Theater on July 22, 2004 in Beverly Hills, California. (Photo by Kevin Winter/Getty Images)
TORONTO, ON - SEPTEMBER 13: Musician/actor Justin Timberlake and director Jonathan Demme and attend the 'Justin Timberlake + The Tennessee Kids' premiere during the 2016 Toronto International Film Festival at Roy Thomson Hall on September 13, 2016 in Toronto, Canada. (Photo by Isaiah Trickey/FilmMagic)
Italy- The jury Photocall- 72nd Venice Film Festival Jonathan Demme at the jury photocall during 72nd Venice Film Festival (Photo by camilla morandi/Corbis via Getty Images)
Jonathan Demme and Oprah Winfrey during DGA Announces Presenters and Guests for 5th Annual DGA Honors - Press Room at The Waldorf Astoria in New York City, New York, United States. (Photo by Dimitrios Kambouris/WireImage)
U.S. director Jonathan Demme poses for photographers during a photocall at the Venice Film Festival September 3, 2008. "Rachel Getting Married" by director Demme is shown in the competition at the Venice Film Festival. REUTERS/Denis Balibouse (ITALY)
Director Jonathan Demme makes a peace sign as he arrives for the world premiere of his new film, "The Manchurian Candidate" in New York, on July 19, 2004. The film will be released on July 30. REUTERS/Albert Ferreira AF
ITALY - SEPTEMBER 03: 65th Venice International Film Festival (Mostra). Photocall of the movie 'Rachel Getting Married' by director Jonathan Demme In Venice, Italy On September 03, 2008-Director Jonathan Demme and actress Anne Hathaway. (Photo by Pool CATARINA/VANDEVILLE/Gamma-Rapho via Getty Images)
NEW YORK, NY - APRIL 20: Jonathan Demme poses as The Academy Museum Presents 25th Anniversary Event Of 'Silence of the Lambs'at The Museum of Modern Art on April 20, 2016 in New York City. (Photo by Donna Ward/FilmMagic)
NEW YORK, NY - NOVEMBER 10: Jonathan Demme attends The 3rd Annual DOC NYC Visionaries Tribute Luncheon at City Winery on November 10, 2016 in New York City. (Photo by Krista Kennell/Patrick McMullan via Getty Images)
LOS ANGELES - FEBRUARY 7: Director Jonathan Demme (L) and actress Jodie Foster arrive at the Los Angeles screening of Paramount Classic's 'Neil Young: Heart of Gold' at the Paramount Theater on February 7, 2006 in Los Angeles, California. (Photo by Kevin Winter/Getty Images)
TORONTO, ON - SEPTEMBER 13: Director Jonathan Demme attends the 'Justin Timberlake + The Tennessee Kids' premiere during the 2016 Toronto International Film Festival at Roy Thomson Hall on September 13, 2016 in Toronto, Canada. (Photo by Tara Ziemba/WireImage)
Actress Susan Sarandon and Director Jonathan Demme attends the Party to celebrate the debut of the PBS anthology television series 'The American Playhouse on November 8, 1981 at The Players Club in New York City. (Photo by Ron Galella/WireImage)
NEW YORK, NY - APRIL 22: Director Jonathan Demme attends Tribeca Talks After The Movie: By Sidney Lumet during the 2016 Tribeca Film Festival at SVA Theatre 2 on April 22, 2016 in New York City. (Photo by Gilbert Carrasquillo/FilmMagic)
VENICE, ITALY - SEPTEMBER 03: Jonathan Demme attends a premiere for 'Spotlight' during the 72nd Venice Film Festival at Sala Grande on September 3, 2015 in Venice, Italy. (Photo by Luca Teuchmann/Getty Images)
Susan Sarandon and Jonathan Demme during Players Club Party Celebrating The American Playhouse - November 18, 1981 at Players Club in New York City, New York, United States. (Photo by Ron Galella/WireImage)
LOS ANGELES, CA - JUNE 14: Director Jonathan Demme attends the 'Jonathan Demme' screening during the 2015 Los Angeles Film Festival at Regal Cinemas L.A. Live on June 14, 2015 in Los Angeles, California. (Photo by Araya Diaz/WireImage)
NEW YORK, NY - JANUARY 20: Director Jonathan Demme attends The Cinema Society & Tod's host the premiere of the Film Arcade & Cinedigm's 'Song One' at Landmark's Sunshine Cinema on January 20, 2015 in New York City. (Photo by Jim Spellman/WireImage)
NEW YORK, NY - JUNE 23: Director Jonathan Demme attends the 'Life Itself' screening at The Film Society of Lincoln Center, Walter Reade Theatre on June 23, 2014 in New York City. (Photo by Michael Stewart/FilmMagic)
VENICE, ITALY - AUGUST 29: Director Jonathan Demme attends the 'Enzo Avitabile Music Life' Photocall during the 69th Venice International Film Festival at Palazzo del Casino on August 29, 2012 in Venice, Italy. (Photo by Pascal Le Segretain/Getty Images)
NEW YORK - JANUARY 15: Producer Jonathan Demme attends An Evening With Jonathan Demme and Neil Young trunk show at the Walter Reade Theater on January 15, 2010 in New York City. (Photo by Mike Coppola/FilmMagic)
Jonathan Demme during DGA Announces Presenters and Guests for 5th Annual DGA Honors - Arrivals at Waldorf Astoria in New York City, New York, United States. (Photo by Dimitrios Kambouris/WireImage)
Director Jonathan Demme attends the 'Mandela' New York City Premiere on March 18, 1997 at Cineplex Worldwide Theater in New York City. (Photo by Ron Galella, Ltd./WireImage)
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The director made his film debut with 1971's "Angels Hard as They Come," but will be best remembered for the aforementioned Oscar-winning films "The Silence of the Lambs" and "Philadelphia." He also directed critically-acclaimed films "The Manchurian Candidate," "Rachel Getting Married" and "Melvin and Howard."

He was also a dedicated documentarian. In addition to his most recent documentary, "Justin Timberlake + the Tennessee Kids," Demme directed "Kenny Chesney: Unstaged," "Neil Young Journeys," "Jimmy Carter Man from Plains" and "Storefront Hitchcock," among others.

In 2015, he directed Meryl Streep in "Ricki and the Flash."

The famously private director shared three children with wife Joanne Howard.

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Celebrities who died in 2016

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