Charlie Murphy, Chappelle Show star and Eddie Murphy's older brother, has died, publicist Domenick Nati told The Hollywood Reporter. He was 57.
Murphy died from leukemia on Wednesday, Nati said.
Murphy became a household name through Dave Chappelle's Comedy Central skit show thanks to his amazing stories of interactions with other celebrities during the height of his brother's fame in the 1980s. The most popular short turned into a skit about Rick James.
The comedian's Twitter account sent a final note on Tuesday evening that read: "One to Sleep On: Release the past to rest as deeply as possible."
Murphy also appeared in numerous movies, TV shows and even lent his voice to some video games.
See photos of Charlie Murphy:
Charlie Murphy throughout his life
Charlie Murphy throughout his life
Charlie Murphy during The 1st Annual American Cinematheque Moving Picture Ball Honoring Eddie Murphy at Century Plaza Hotel in Los Angeles, California, United States. (Photo by Ron Galella, Ltd./WireImage)
LOS ANGELES - APRIL 6, 1987: Comedian Eddie Murphy Charlie Murphy pose for a portrait in April 6, 1987 in Los Angeles, California. (Photo by Donaldson Collection/Michael Ochs Archives/Getty Images)
UNITED STATES - MARCH 18: Eddie Murphy's brothers Charlie Murphy & Vernon Lynch at Wedding for Eddie Murphy at Plaza Hotel. (Photo by Richard Corkery/NY Daily News Archive via Getty Images)
NEW YORK - JANUARY 1: Actors Charlie Murphy (L) and Donnell Rawlings (R) of Chappelle's Show flank singer Foxy Brown courtside at the New York Knicks game against the New Jersey Nets at Madison Square Garden on January 1, 2005 in New York City. (Photo by Ray Amati/Getty Images)
Charlie Murphy during 2005 Bonnaroo - Pre-Festivities - Charlie Murphy at Yet Another Comedy Tent in Manchester, Tennessee, United States. (Photo by Jeff Kravitz/FilmMagic)
Charlie Murphy at the Magic Johnson Theater in Harlem, New York (Photo by Rabbani and Solimene Photography/WireImage)
NEW YORK - OCTOBER 24: Comedians (L-R) Donnell Rawlings, Charlie Murphy, Jackie Martling and Adrianne Curry attend the 6th Annual High Times Stony Awards at B.B. King's on October 20, 2006 on Broadway in New York City. (Photo by Donna Ward/Getty Images)
Tom Meyer-Klipsch and Charlie Murphy during 2006 MTV Video Music Awards - Explicit Events Presents Klipsch Audio at the Style Villa - Day 3 at Bryant Park Hotel in New York City, New York, United States. (Photo by Djamilla Rosa Cochran/WireImage for Explicit Events)
NEW YORK - NOVEMBER 16: Comedian Charlie Murphy speaks at the Sony PlayStation 3 Launch Party at the Sony Style Store on November 16, 2006 in New York City. Sony allowed 400 people to purchase the new Sony PlayStation 3 at the party. (Photo by Brad Barket/Getty Images )
Charlie Murphy and family during 'Norbit' Los Angeles Premiere at Mann Village in Westwood, California, United States. (Photo by Barry King/WireImage)
NEW YORK - JUNE 04: Actor Charlie Murphy appears on BET's 106 & Park June 4, 2007 in New York City. (Photo by Scott Gries/Getty Images)
Charlie Murphy, Claudia Jordan and Guy Torry during BET Awards 2007 - Photo Gallery at Shrine Auditorium in Los Angeles, California, United States. (Photo by Arnold Turner/WireImage for BET Network)
Charlie Murphy and Vivica A. Fox presents Best Hip-Hop Artist award (Photo by Michael Caulfield/WireImage for BET Network)
NEW YORK - JULY 23: Comedian Charlie Murphy appears during taping of BET 106 & Park on July 23, 2007 in New York City. (Photo by Brad Barket/Getty Images)
HOLLYWOOD, FL - AUGUST 04: Comedian Charlie Murphy performs his stand up act in the Improv Comedy Club at the Seminole Hard Rock Hotel and Casino on August 4, 2007 in Hollywood, Florida. (Photo by Kyle Hoelzel/Getty Images)
LOS ANGELES, CA - AUGUST 25: (L-R) Host Charlie Murphy and performer Baby Bash pose at the Lipton Brisk Green Block Party hosted by Murphy at LA Center Studios on August 25, 2007 in Los Angeles, California. (Photo by Ryan Miller/Getty Images)
NEW YORK - DECEMBER 10: (L-R) Actors Charlie Murphy, Gabrielle Union and Morris Chestnut attend the 'Perfect Holiday' Celebration at Marquee on December 10, 2007 in New York City. (Photo by Steven Henry/Getty Images)
NEW YORK - DECEMBER 12: (U.S. TABS OUT) Actor Charlie Murphy attends a taping of BET's 106 & Park at the BET Studios on December 12, 2007 in New York City. (Photo by Scott Gries/Getty Images)
NEW BRUNSWICK, NJ - MAY 23: Charlie Murphy performs as he headlines at The Stress Factory Comedy Club on May 23, 2009 in New Brunswick, New Jersey. (Photo by Bobby Bank/WireImage)
NEW YORK - OCTOBER 16: Comedian Charlie Murphy attends a concert presented by Heineken Red Star Soul at Gotham Hall on October 16, 2009 in New York City. (Photo by Mike Coppola/Getty Images)
NEW YORK - MARCH 09: Actor Charlie Murphy attends the premiere of 'Our Family Wedding at AMC Loews Lincoln Square 13 theater on March 9, 2010 in New York City. (Photo by Jim Spellman/WireImage)
Shondrella Avery and Actor Charlie Murphy attends the premiere of Our Family Wedding at AMC Loews Lincoln Square 13 theater on March 9, 2010 in New York City. (Photo by Jim Spellman/WireImage)
NEW BRUNSWICK, NJ - MAY 28: Charlie Murphy headlines The Stress Factory Comedy Club on May 28, 2010 in New Brunswick, New Jersey. (Photo by Bobby Bank/WireImage)
(L-R) Charlie Murphy and Coco attend Coco's birthday party at the Hudson Eatery on April 3, 2010 in New York City. (Photo by Johnny Nunez/WireImage)
LOS ANGELES, CA - AUGUST 12: Director Erik White, Charlie Murphy and Ice Cube arrive at the after party for 'Lottery Ticket' at Grauman's Chinese Theatre on August 12, 2010 in Los Angeles, California. (Photo by Todd Williamson/WireImage)
NEW YORK, NY - JUNE 04: Actor Charlie Murphy visits the SIRIUS XM Studio on June 4, 2011 in New York City. (Photo by Johnny Nunez/WireImage)
BEVERLY HILLS, CA - NOVEMBER 03: Presenter Charlie Murphy speaks onstage at Spike TV's 'Eddie Murphy: One Night Only' at the Saban Theatre on November 3, 2012 in Beverly Hills, California. (Photo by Mark Davis/WireImage)
BEVERLY HILLS, CA - NOVEMBER 03: (L-R) Actor Charlie Murphy and honoree Eddie Murphy arrive at Spike TV's 'Eddie Murphy: One Night Only' at the Saban Theatre on November 3, 2012 in Beverly Hills, California. (Photo by Jeff Kravitz/FilmMagic)
NEW BRUNSWICK, NJ - NOVEMBER 14: Charlie Murphy performs at The Stress Factory Comedy Club on November 14, 2014 in New Brunswick, New Jersey. (Photo by Bobby Bank/WireImage)
NEW YORK, NY - AUGUST 07: Comedian Charlie Murphy visits at SiriusXM Studios on August 7, 2014 in New York City. (Photo by Rommel Demano/Getty Images)
INGLEWOOD, CA - AUGUST 22: Comedian Charlie Murphy performs onstage at the The Comedy Get Down presented by 93.5 KDAY at The Forum on August 22, 2015 in Inglewood, California. (Photo by Matthew Simmons/Getty Images)
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The actor and comedian was on record as saying he was a hothead when he worked as a bodyguard for his brother. He said he loved Eddie so much, and thought he was so funny, that he would pick fights with people who did not laugh at his brother's jokes when he performed.
Murphy is also remembered for his amazing tale about the legendary musician, Prince. Made into a skit for Chappelle Show, Murphy said he and friends played basketball against Prince and his entourage one night in the 1980s. Murphy said he was shocked how good Prince was at the game. Afterward, Prince made everyone pancakes. Prince was on record saying the story was true, even the breakfast.
"We just lost one of the funniest most real brothers of all time . Charlie Murphy RIP," Chris Rock wrote on Twitter. Mogul Russell Simmons tweeted: "Just came out of meditation and learned that one of my friends and my biggest comedy idol passed. Damn I loved Charlie Murphy."
"Terribly saddened ... Charlie," comedian Paul Mooney wrote.