Don Rickles, one of the most influential comedians in history, has died at the age of 90.
Rickles passed away from kidney failure on Thursday morning in his Los Angeles home, his longtime publicist confirmed. He would have turned 91 on May 8.
His wife of 52 years, Barbara, was by his side at the time of his death.
The icon, whose career spanned more than seven decades, is known as the best "insult comic" ever. His first big break came in 1965 when he appeared on "The Tonight Show With Johnny Carson." Soon after, he reached headliner status in Las Vegas, Reno and Lake Tahoe.
Don Rickles through the years
Don Rickles through the years
JIMMY KIMMEL LIVE - 'Jimmy Kimmel Live' airs every weeknight at 11:35 p.m. EST and features a diverse lineup of guests that include celebrities, athletes, musical acts, comedians and human interest subjects, along with comedy bits and a house band. The guests for Monday, October 10 included Don Rickles (Don Rickles at The Orleans Hotel in Las Vegas), John Stamos (Scream Queens) and musical guest Two Door Cinema Club. (Randy Holmes/ABC via Getty Images)
THE DANNY THOMAS HOUR -- 'Sea World' Episode 6 -- Pictured: Don Rickles at Sea World San Diego -- (Photo by: NBC/NBCU Photo Bank via Getty Images)
THE DANNY THOMAS HOUR -- 'Sea World' Episode 6 -- Pictured: Don Rickles kisses Shamu the Whale at Sea World San Diego -- (Photo by: NBC/NBCU Photo Bank via Getty Images)
UNITED STATES - JULY 23: THE DON RICKLES SHOW - 'Misc.' 1968 Extra, Don Rickles (Photo by ABC Photo Archives/ABC via Getty Images)
THE TONIGHT SHOW STARRING JIMMY FALLON -- Episode 0488 -- Pictured: (l-r) Comedian Don Rickles during an interview with host Jimmy Fallon on June 14, 2016 -- (Photo by: Andrew Lipovsky/NBC/NBCU Photo Bank via Getty Images)
UNITED STATES - JULY 21: THE DON RICKLES SHOW - 'With Lorne Greene' 1968 Don Rickles, Lorne Green (Photo by ABC Photo Archives/ABC via Getty Images)
THE TONIGHT SHOW STARRING JIMMY FALLON -- Episode 0305 -- Pictured: Comedian Don Rickles on August 4, 2015 -- (Photo by: Douglas Gorenstein/NBC/NBCU Photo Bank via Getty Images)
From second left: American actor George Raft (1901 - 1980), talk show host Johnny Carson (1925 - 2005) and comedian Don Rickles, at the Friars Club Roast of George Raft, at the Beverly Hilton Hotel, Los Angeles, California, 6th February 1975. (Photo by Silver Screen Collection/Getty Images)
Whoopi Goldberg & Don Rickles during 1992 HBO's Comic Relief in Los Angeles, California, United States. (Photo by Jeff Kravitz/FilmMagic, Inc)
Don Rickles during Don Rickles in Concert - October 7, 2005 at Resorts Casino in Atlantic City, New Jersey, United States. (Photo by Tom Briglia/FilmMagic)
KRAFT MUSIC HALL -- 'Friars Roast of Jerry Lewis' Episode 1317 -- Pictured: Don Rickles -- (Photo by: NBC/NBCU Photo Bank via Getty Images)
387274 09: Actor Don Rickles attends the Spago closing party hosted by celebrity chef Wolfgang Puck and his wife Barbara Lazaroff March 28, 2001 in West Hollywood, CA. Puck and Lazaroff will be closing their Hollywood restaurant at the end of the month. (Photo by Newsmakers)
UNITED STATES - JUNE 17: THE JOEY BISHOP SHOW - (1968) Don Rickles (Photo by ABC Photo Archives/ABC via Getty Images)
THE TONIGHT SHOW WITH JAY LENO -- Episode 904 -- Pictured: Comedian Don Rickles on April 18, 1996 -- (Photo by: Margaret C. Norton/NBC/NBCU Photo Bank via Getty Images)
BEVERLY HILLS, CA - FEBRUARY 29: Comic Don Rickles and wife Barbara Sklar attend 24th Annual American Film Institute Lifetime Achievement Awards Honoring Clint Eastwood on February 29, 1996 at the Beverly Hilton Hotel in Beverly Hills, California. (Photo by Ron Galella, Ltd./WireImage)
Comic Don Rickles attends 31st Annual Thalians Ball Honoring Shirley MacLaine on October 11, 1986 at the Century Plaza Hotel in Century City, California. (Photo by Ron Galella, Ltd./WireImage)
CENTURY CITY, CA - DECEMBER 3: Actress Dinah Shore, comic Don Rickles and wife Barbara Sklar attend the premiere of 'Crimes Of The Heart' on December 3, 1986 at the Plitt Theater in Century City, California. (Photo by Ron Galella, Ltd./WireImage)
THE TONIGHT SHOW STARRING JOHNNY CARSON -- Pictured: (l-r) Actor Gabe Kaplan during an interview with Guest Host Don Rickles on October 13th, 1975 -- (Photo by:Ron Tom/NBC/NBCU Photo Bank via Getty Images)
THE TWILIGHT ZONE. Don Rickles in 'Mr. Dingle, The Strong', episode 19 of season 2 of CBS' science fiction television series, 'The Twilight Zone', July 29, 1960. (Photo by CBS Photo Archive/Getty Images)
LOS ANGELES - JULY 29: THE TWILIGHT ZONE. Don Rickles, left, and Burgess Meredith in 'Mr. Dingle, The Strong.' Image dated July 29, 1960. Original airdate March 3, 1961 (Season 2, Episode 19). (Photo by CBS via Getty Images)
WEST HOLLYWOOD, CA - JUNE 25: Comic Don Rickles and actor Bob Newhart attend the birthday party for Marvin Davis on June 25, 1991 at Spago Restaurant in West Hollywood, California. (Photo by Ron Galella, Ltd./WireImage)
LOS ANGELES - SEPTEMBER 19: Comic Don Rickles sighted on September 19, 1991 at the Los Angeles International Airport in Los Angeles, California. (Photo by Ron Galella, Ltd./WireImage)
THE TONIGHT SHOW STARRING JOHNNY CARSON -- Pictured: (l-r) Comedian Don Rickles during an interview with host Johnny Carson on May 31, 1991 -- (Photo by: Gary Null/NBC/NBCU Photo Bank via Getty Images)
Comedian Don Rickles speaks at the Hollywood Walk of Fame star presentation ceremony for director John Lasseter, in Hollywood, California, November 1, 2011. AFP PHOTO / Robyn Beck (Photo credit should read ROBYN BECK/AFP/Getty Images)
THE TONIGHT SHOW WITH JAY LENO -- Episode 4075 -- Pictured: )Comedian Don Rickles during an interview on July 14, 2011 (Photo by Paul Drinkwater/NBC/NBCU Photo Bank via Getty Images)
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He was also a regular on Dean Martin's "Celebrity Roast," which perfectly showcased his no-mercy stand-up comedy style that earned him the nickname "The Merchant of Venom." The comedian's roast of then-president Ronald Reagan (which you can watch here) during his inaugural ball in 1985 is one of Rickles' most noteworthy performances.
Don found the most success in his TV guest appearances throughout the years, appearing in a variety of shows like "The Lucy Show," "Get Smart" and "Hot In Cleveland." He also had his own show, "The Don Rickles Show," which only lasted one season in 1972.
Later in his career, he became the voice of Mr. Potato Head in the "Toy Story" films. According to IMDb, he was set to reprise his role in "Toy Story 4," which is expected to premiere in 2019.
The industry icon has remained out of the spotlight in recent years.
The day after Johnny Carson's death in 2005, Don appeared with Bob Newhart, whom he considered his best friend, on "The Tonight Show With Jay Leno" to pay tribute to the longtime host. In 2014, the funnyman was honored by the likes of David Letterman, Jerry Seinfeld and Jon Stewart in the Spike TV special "One Night Only: An All-Star Comedy Tribute to Don Rickles."
He also penned a memoir, "Rickles' Book," that was published in 2007. A documentary about his career, "Mr. Warmth: The Don Rickles Project," debuted on HBO later that year -- his performance in the special earned him an Emmy for individual performance in a variety or music program.
The legend was born in Manhattan in 1926 and studied acting at the Academy of Dramatic Arts in New York City after serving in the Navy during World War II.
Rickles is survived by his wife, Barbara, his daughter, Mindy Mann, Mann's husband Ed, and two grandchildren, Ethan and Harrison Mann.
Stars react to Don Rickles' death
Stars react to Don Rickles' death
90 years with Don Rickles weren't enough. One of the sweetest and most lovely people I had the pleasure of knowing. We miss you already
Don Rickles has passed away.
A giant loss.
Don once begged me for a couple of bucks then told me to twist myself into a pretzel. Ego slayer! Comic Everest! Spank you, Mr Rickles. ;^)
Awwww man Rickles is dead. Rest In Peace buddy.
RIP Don Rickles. One of the funniest people that ever lived, you dumb schmuck.
Don Rickles, you kept us laughing for so many years. We will miss you dearly. Thanks for the zingers. You were one of a kind.
#RIP Don Rickles! https://t.co/xkRSabFfWX
One person I always wanted to meet and shake hands with.
RIP Don Rickles
In lieu of flowers, Don Rickles' family has requested that people drop their pants and fire a rocket. #RIPDonRickles
Hockey puck. We've lost @DonRickles I love him so. Smart, funny, a pro and most important deeply and honestly kind. Kind is what matters.
Quite simply one of the funniest ever.
RIP Don Rickles 90 https://t.co/xiZf1U1g6J
RIP to this sweet and lovely man https://t.co/j8mseq1aSY
Aw jeez. Rickles .Sweetest, funniest, legend and mensch. Came to a party at my house gave me a dollar and told me to get a nicer place.#RIP
RIP Don Rickles. Your humor would be lost on the young today. Say hi to Joan.
1. A Don Ricles story. My dad loved Don Rickles and always said he wanted to be subjected to a Don Rickles insult.
RIP Don Rickles... thank you for the laughs https://t.co/V4QK8rcct4
Don Rickles, king of insult comedy, dies at 90 - https://t.co/XSsKQx2d64
He never was Politically Correct and he never apologized for it. R.I.P. Don Rickles @DonRickles
My friend, my dad, the funniest biggest hearted of them all. A beautiful husband and father. My heart is broken. Rest In Peace. Don Rickles.
As Don Rickles said so many times over the years, "The senate filibuster rule is the only thing keeping me alive." :(
Don Rickles, such sharp hilarious wit in an era when an insult comic didn't need to be vulgar to be funny. You will… https://t.co/w7HSLNQslW
I saw Don Rickles at the Daily Show once. He had no idea who I was. He looked at my face & said "Stop worrying. It'… https://t.co/t0KzIlQrad
As I was standing nearby, #DonRickles once whispered in my wife's ear, "What are you doing with a loser like him?" I was honored. #rip #sad
90 years old. Didn't look a day over 214. Nice job dying, you hockey puck.
Rickles was awesome.
One of the funniest, ballsiest comics of all time. RIP Don Rickles. https://t.co/wF9rPQjjVz
God Bless Don Rickles, aka, Mr. Warmth! Proud to have been heckled by him from the stage many times! #RIP
Rickles is gone. He was the best, you hockey pucks. RIP
JFK/LAX we spoke for 3 hours while his beautiful wife Barbara slept.
Don Rickles was so kind to me I forgot we'd never met
Don Rickles created a style of stand up and owned (!!!) it his entire career of 60+ years. It's unparalleled. No, I mean, NO ONE did that.