"My Social Security payroll contribution will go up, as will Donald's — if he can't figure out how to get out of it," she replied, to which Trump interrupted by saying, "Such a nasty woman."
While Clinton seemed unfazed, the Twitterverse took notice, especially in the wake of lewd comments Trump has made about women in the past recently coming to light.
See photos of Janet Jackson through the years:
Janet Jackson arrives at amfAR's 20th Annual Cinema Against AIDS at Hotel du Cap-Eden-Roc on May 23, 2013 in Cap d'Antibes, France. (Photo by Tony Barson/FilmMagic,)
MILAN, ITALY - FEBRUARY 25: Janet Jackson attends the Giorgio Armani fashion show as part of Milan Fashion Week Womenswear Fall/Winter 2013/14 on February 25, 2014 in Milan, Italy. (Photo by Vittorio Zunino Celotto/Getty Images)
LOS ANGELES, CA - SEPTEMBER 08: Janet Jackson attends the Dylan's Candy Bar Los Angeles Opening at Original Farmers Market on September 8, 2012 in Los Angeles, California. (Photo by John Sciulli/WireImage)
ANTIBES, FRANCE - MAY 24: Janet Jackson arrives at the 2012 amfAR's Cinema Against AIDS during the 65th Annual Cannes Film Festival at Hotel Du Cap on May 24, 2012 in Cap D'Antibes, France. (Photo by Dominique Charriau/WireImage)
NEW YORK, NY - MAY 10: Janet Jackson attends the Marco Glaviano 'Supermodels' exhibition opening at the Keszler Gallery on May 10, 2012 in New York City. (Photo by Jim Spellman/WireImage)
MIAMI BEACH, FL - DECEMBER 05: Janet Jackson performs at Fillmore Miami Beach on December 5, 2011 in Miami Beach, Florida. (Photo by Larry Marano/Getty Images)
LONDON, ENGLAND - JUNE 30: Janet Jackson performs on her Janet Jackson Number Ones: Up Close & Personal Tour at The Royal Albert Hall on June 30, 2011 in London, England. (Photo by Dave J Hogan/Getty Images)
BERLIN, BERLIN - JUNE 24: US singer Janet Jackson performs live at the Tempodrom on June 24, 2011 in Berlin, Germany. (Photo by Marco Prosch/WireImage)
US singer Janet Jackson speaks during the 19th Life Ball in front of the city hall in Vienna, Austria, on May 21, 2011. The Life Ball is a charity gala to raise money for people living with HIV and AIDS.AFP PHOTO/JOE KLAMAR (Photo credit should read JOE KLAMAR/AFP/Getty Images)
Janet Jackson attends amfAR's Cinema Against AIDS Gala during the 64th Annual Cannes Film Festival at Hotel Du Cap on May 19, 2011 in Antibes, France. (Photo by Tony Barson/WireImage)