'Grey's Anatomy' star Sara Ramirez comes out as bisexual

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Sara Ramirez is speaking her truth.

The 41-year-old actress revealed that she's bisexual while giving a speech at the True Colors Fund's 40 to None Summit in Los Angeles on Saturday.

WATCH: 'Grey's Anatomy' Boss Addresses Sara Ramirez's Exit: 'I Had a Different Plan'

"So many of our youth experiencing homelessness are youth whose lives touch on many intersections – whether they be gender identity, gender expression, race, class, sexual orientation, religion, citizenship status," she said.

"Because of the intersections that exist in my own life: Woman, multi-racial woman, woman of color, queer, bisexual, Mexican-Irish American, immigrant, and raised by families heavily rooted in Catholicism on both my Mexican & Irish sides," she continued, "I am deeply invested in projects that allow our youth's voices to be heard, and that support our youth in owning their own complex narratives so that we can show up for them in the ways they need us to."

Ramirez also took to Twitter to confirm the news.

"#40ToNoneSummit #SpeakingMyTruth!" she wrote. "Will post full video of speech soon! #ThankYou @TrueColorsFund #WomanOfColor #Bisexual #Queer #Immigrant."

WATCH: Is Sara Ramirez Leaving 'Grey's Anatomy' After This Season?

Fans were quick to applaud the actress for her courage.

RELATED: 'Grey's Anatomy' Star Sara Ramirez Gets Married

Ramirez, who married husband Ryan DeBolt in 2012, has never spoken openly about her sexuality, despite playing a bisexual character, Callie Torres, on Grey's Anatomy. The actress announced she was leaving the show in May, after 10 seasons.

"I'm deeply grateful to have spent the last 10 years with my family at Grey's Anatomy & ABC but for now, I'm taking some welcome time off," she wrote on Twitter. "Shonda [Rhimes has] been so incredible to work for, & we will definitely continue our conversations!"

PHOTOS: Sara Ramirez through the years

20 PHOTOS
Sara Ramirez through the years
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Sara Ramirez through the years
GREY'S ANATOMY - 'When It Hurts So Bad' - Meredith takes a step forward with Will but quickly regrets it; Maggie senses a disconnection with Andrew; and Amelia reevaluates her relationship with Owen. Meanwhile, Catherine comes into town and really shakes things up with April and Jackson, on 'Grey's Anatomy,' THURSDAY, MARCH 31 (8:00-9:00 p.m. EDT) on the ABC Television Network. (Photo by Ron Batzdorff/ABC via Getty Images) SARA RAMIREZ
NEW YORK, NY - OCTOBER 03: Sara Ramirez attends the New York premiere of MarVista Entertainment's LOSERVILLE in partnership with STOMP Out Bullying at Village East Cinema on October 3, 2016 in New York City. (Photo by Craig Barritt/Getty Images for MarVista Entertainment )
HOLLYWOOD, CA - SEPTEMBER 29: Actress and Producer Sara Ramirez attends the premiere of Marvista Entertainment's 'Loserville' at ArcLight Hollywood on September 29, 2016 in Hollywood, California. (Photo by Justin Baker/Getty Images)
GREY'S ANATOMY - 'I Am Not Waiting Anymore' - Jackson learns about April's pregnancy, while Alex and the team of doctors handles an hours-long triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not receiving special treatment after he and Maggie go public, on 'Grey's Anatomy,' THURSDAY, MARCH 24 (8:00-9:00 p.m. EDT) on the ABC Television Network. (Photo by Richard Cartwright/ABC via Getty Images) SARA RAMIREZ, JESSICA CAPSHAW
NEW YORK, NY - NOVEMBER 02: Sara Ramirez appears to promote 'TED TALKS LIVE' at The Empire State Building on November 2, 2015 in New York City. (Photo by Donna Ward/Getty Images)
GREY'S ANATOMY - 'All Eyez On Me' - Meredith, Bailey, Jackson, Callie and Jo travel to a military hospital to perform an extraordinary and extremely risky surgery on a veteran with an advanced tumor. Meanwhile back at Grey Sloan, Andrew is tired of being Maggie's worst kept secret; Ben makes an impulsive surgical decision; and a team of cheerleaders wreak havoc in the ER, on 'Grey's Anatomy,' THURSDAY, MARCH 10 (8:00-9:00 p.m. EST) on the ABC Television Network. (Photo by Ron Batzdorff/ABC via Getty Images) SARA RAMIREZ
LOS ANGELES, CA - OCTOBER 03: Singer/actress Sara Ramirez performs onstage during the Point Foundation's Annual Voices On Point Gala at the Hyatt Regency Century Plaza on October 3, 2015 in Los Angeles, California. (Photo by Jason Kempin/Getty Images for The Point Foundation)
WEST HOLLYWOOD, CA - SEPTEMBER 26: Actress Sara Ramirez attends ABC's TGIT premiere event on September 26, 2015 in West Hollywood, California. (Photo by Jason LaVeris/FilmMagic)
WEST HOLLYWOOD, CA - SEPTEMBER 26: Sara Ramirez attends the Celebration of ABC's TGIT Line-up presented by Toyota and co-hosted by ABC and Time Inc.'s Entertainment Weekly, Essence and People at Gracias Madre on September 26, 2015 in West Hollywood, California. (Photo by JB Lacroix/WireImage)
LOS ANGELES, CA - MARCH 14: Singer Sara Ramirez attends 2015 Human Rights Campaign Los Angeles Gala Dinner at The JW Marriott Los Angeles at L.A. LIVE on March 14, 2015 in Los Angeles, California. (Photo by Paul Archuleta/FilmMagic)
NEW YORK, NY - MAY 12: Actress Sara Ramirez attends the 2015 ABC upfront presentation at Avery Fisher Hall at Lincoln Center for the Performing Arts on May 12, 2015 in New York City. (Photo by Jim Spellman/WireImage)
LOS ANGELES, CA - MARCH 14: Actress Sara Ramirez attends the Human Rights Campaign Los Angeles Gala 2015 at JW Marriott Los Angeles at L.A. LIVE on March 14, 2015 in Los Angeles, California. (Photo by Jason Kempin/Getty Images for Human Rights Campaign)
WEST HOLLYWOOD, CA - SEPTEMBER 20: Actress Sara Ramirez arrives at the #TGIT Premiere Event hosted by Twitter at Palihouse Holloway on September 20, 2014 in West Hollywood, California. (Photo by Amanda Edwards/WireImage)
GREY'S ANATOMY - 'You've Got To Hide Your Love Away' - After an anonymous complaint is issued by one of their own, the hospital implements a non-fraternizing policy causing the couples to panic. Meanwhile, Emma and Owen talk about the future, Cristina and Meredith enjoy a little girl time and Richard enlists the residents to help research a rare cancer case, on 'Grey's Anatomy,' THURSDAY, MARCH 6 (9:00-10:00 p.m., ET) on the ABC Television Network. (Eric McCandless/ABC via Getty Images) SARA RAMIREZ, ELLEN POMPEO, SANDRA OH
THE VIEW - Medal of Honor recipient Sergeant Dakota Meyer guest co-hosts; Sara Ramirez (ABC's 'Grey's Anatomy'); musical guest Julian Lennon. 'The View' airs Monday-Friday (11:00 am-12:00 pm, ET) on the ABC Television Network. (Photo by Lou Rocco/ABC via Getty Images) SARA RAMIREZ
LOS ANGELES, CA - SEPTEMBER 28: Actress Sara Ramirez attends the 200th episode celebration of 'Grey's Anatomy' at The Colony on September 28, 2013 in Los Angeles, California. (Photo by Paul Archuleta/FilmMagic)
LOS ANGELES, CA - SEPTEMBER 28: Sara Ramirez attends 'Grey's Anatomy' 200th Episode party held at The Colony on September 28, 2013 in Los Angeles, California. (Photo by JB Lacroix/WireImage)
LOS ANGELES, CA - SEPTEMBER 28: Actors Danielle Bisutti (L) and Sara Ramirez (R) attend the 200th episode celebration of 'Grey's Anatomy' at The Colony on September 28, 2013 in Los Angeles, California. (Photo by Paul Archuleta/FilmMagic)
BEVERLY HILLS, CA - AUGUST 04: Sara Ramirez arrives at the 2013 Television Critics Association's Summer Press Tour - Disney/ABC Party at The Beverly Hilton Hotel on August 4, 2013 in Beverly Hills, California. (Photo by Steve Granitz/WireImage)
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