The adult animated film from Sony is expected to ring up $34 million at 3,103 locations making it the largest August opening ever for an animated film.
"Sausage Party" is about an assortment of supermarket food items that devise a plan to escape upon learning that their fate is consumption. It is directed by Conrad Vernon and Greg Tiernan. The cast is lead by co-writer Seth Rogen and also includes Michael Cera, James Franco, Salma Hayek, Jonah Hill, Nick Kroll, David Krumholtz, Danny McBride, Edward Norton, Paul Rudd, and Kristen Wiig.
Despite the R-rated comedy's strong start and other new arrivals in "Pete's Dragon" and "Florence Foster Jenkins," "Suicide Squad" will remain on top of the box office in its second frame.
After its $13 million Friday earnings, the Warner Bros. supervillain film is taking aim at a second week in the $46 million range on 4,255 screens. The film smashed August records with a $133.7 million opening weekend, despite receiving mostly negative reviews.
Its second frame looks to amount to about a 66% decline. "Batman v Superman: Dawn of Justice," which was also panned by critics, saw a 69% decline in its second weekend after a $166 million opening.
The trio of newcomers, meanwhile, have received favorable critiques and currently all sit above 80% on Rotten Tomatoes: "Sausage Party" (82%); "Pete's Dragon" (86%); "Florence Foster Jenkins" (88%).
Disney's "Pete's Dragon" was expected to land in second place behind "Suicide Squad" this weekend, but instead it is taking off in the $22 million range at 3,702 locations, earning it the bronze. The remake of Disney's 1977 original about a boy and his dragon, Elliot, stars Bryce Dallas Howard and Oakes Fegley.
Forecasts show "Florence Foster Jenkins" — playing in 1,528 theaters — crooning its way to a $6 million opening weekend. The film, from Paramount, is already generating Oscar buzz for performances from Meryl Streep and Hugh Grant. Stephen Frears directed the story of an aspiring opera singer who doesn't realize her vocal limitations.
Check out more from Seth Rogen in the gallery below!
LOS ANGELES, CA - DECEMBER 25: Seth Rogen attends Sony Pictures' 'The Interview' opening on Christmas Day at Cinefamily in Los Angeles, CA. Sony hackers have released stolen information and threatened attacks on theaters which screened the film. (Photo by Justin Baker/WireImage)
LOS ANGELES, CA - DECEMBER 25: Writer/director Seth Rogen introduces the screening of Sony Pictures' 'The Interview' at Cinefamily on December 25, 2014 in Los Angeles, California. (Photo by David Livingston/Getty Images)
LOS ANGELES, CA - DECEMBER 25: Writers Evan Goldberg and Seth Rogen attend Sony Pictures' 'The Interview' opening on Christmas Day at Cinefamily on December 25, 2014 in Los Angeles, CA. Sony hackers have released stolen information and threatened attacks on theaters which screened the film. (Photo by Justin Baker/WireImage)
Cast members Paul Rudd (L) and Seth Rogen pose at the premiere of "Knocked Up" in Los Angeles, California May 21, 2007. REUTERS/Fred Prouser (UNITED STATES)
Seth Rogen, writer of the movie "Superbad", poses at the Culver Studios in Culver City, California August 3, 2007. The movie opens in the U.S. August 17. REUTERS/Mario Anzuoni (UNITED STATES)
Presenters Seth Rogen (R) and Jonah Hill arrive backstage at the 80th annual Academy Awards, the Oscars, in Hollywood, February 24, 2008. REUTERS/Mike Blake (UNITED STATES-OSCARS)
Cast member Seth Rogen attends the premiere of "The Green Hornet" at the Grauman's Chinese theatre in Hollywood, California January 10, 2011. The movie opens in the U.S. on January 14. REUTERS/Mario Anzuoni (UNITED STATES - Tags: ENTERTAINMENT)
Cast members Seth Rogen (L) and Danny McBride attend the premiere of the film "Kung Fu Panda 2" in Los Angeles May 22, 2011. REUTERS/Phil McCarten (UNITED STATES - Tags: ENTERTAINMENT)
Actor Seth Rogen and wife Lauren Miller arrive at the 69th annual Golden Globe Awards in Beverly Hills, California January 15, 2012. REUTERS/Danny Moloshok (UNITED STATES - Tags: ENTERTAINMENT) (GOLDENGLOBES-ARRIVALS)
Barbra Streisand and Seth Rogen, stars of the new film "The Guilt Trip" pose as they arrive at the film's premiere in Los Angeles December 11, 2012. REUTERS/Fred Prouser (UNITED STATES - Tags: ENTERTAINMENT)
Presenters for the best shirtless performance, Seth Rogen (L), Zac Efron (C) and Danny McBride, decide to have a best bottomless competition at the 2013 MTV Movie Awards in Culver City, California April 14, 2013. REUTERS/Danny Moloshok (UNITED STATES Tags: Entertainment) (MTV-SHOW)
Seth Rogen (L) and Evan Goldberg speak after accepting their Comedy Filmmakers of the Year award at the Big Screen Achievement Awards during CinemaCon, the official convention of the National Association of Theatre Owners, at Caesars Palace in Las Vegas, Nevada March 27, 2014. REUTERS/Steve Marcus (UNITED STATES - Tags: ENTERTAINMENT)
Cast members James Franco (L) and Seth Rogen pose during the premiere of the film "The Interview" in Los Angeles, California December 11, 2014. REUTERS/Kevork Djansezian (UNITED STATES - Tags: ENTERTAINMENT)
Actors Seth Rogen (R) and Lauren Miller Rogen stumble down a step as they walk on stage during We Day California in Inglewood, California, April 7, 2016. REUTERS/Danny Moloshok TPX IMAGES OF THE DAY
Cast member Seth Rogen poses at the premiere for the movie "Sausage Party" in Los Angeles, California U.S., August 9, 2016. REUTERS/Mario Anzuoni