Her lead narrows when third-party candidates are included, taking 40 percent to Trump's 38 percent, with Libertarian nominee Gary Johnson pulling 5 percent and Green Party candidate Jill Stein with 3 percent.
Clinton's lead is bolstered by women, who back Clinton over Trump by a margin of 54 percent to 30 percent, as well as minority voters. Black voters support Clinton over Trump by a whopping 93 percent to 4 percent, while Hispanic voters back Clinton over Trump 65 percent to 18 percent.
See some of the most noteworthy figures who back Clinton
Important people who support Hillary Clinton (Politicians, famous figures, other celebs)
Voters would rather invite Trump to a BBQ, but want Clinton to be president, poll finds
Warren Buffett, chairman and chief executive officer of Berkshire Hathaway Inc., smiles during an event with Hillary Clinton, former Secretary of State and 2016 Democratic presidential candidate, in Omaha, Nebraska, U.S., on Wednesday, Dec. 16, 2015. Buffet said at the rally that he was supporting Clinton's bid for president because they share a commitment to help the less affluent. (Photographer: Daniel Acker/Bloomberg via Getty Images)
Governor Jerry Brown, seen here with then-candidate Bill Clinton in 1992, notoriously did not like the Clintons for years, but announced a week before the California primary that he would back Hillary Clinton. (Photo by Cynthia Johnson/Getty)
Actor Leonardo DiCaprio, seen here at the 2016 Vanity Fair Oscar Party, hasn't formally endorsed Hillary Clinton but he has donated $2700 to her campaign and backed her in 2008. (Photo by Axelle/Bauer-Griffin/FilmMagic)
Walter Mondale was the first former Democratic vice president to endorse Clinton (REUTERS/Craig Lassig)
Rep. John Lewis, D-Ga., has been an early Clinton backer, seen here at a 'Super Tuesday' watch party her campaign in Atlanta, Ga., March 1, 2016. He is famous for his work fighting for civil rights alongside Dr. Martin Luther King Jr. (Photo By Tom Williams/CQ Roll Call)
LEBANON, NH - JANUARY 09: Former U.S. Women's National Soccer Team captain Abby Wambach smiles while she is introduced to a crowd at a Hillary Clinton campaign office on January 9, 2016 in Lebanon, New Hampshire. Wambach highlighted Democratic presidential candidate Hillary Clinton's commitment to standing up for women and girls. (Photo by Scott Eisen/Getty Images)
Singer Demi Lovato, seen here onstage at WE Day California 2016, is a Clinton supporter. (Photo by Mike Windle/Getty Images for WE Day )
Actress and screenwriter Lena Dunham campaigns for U.S. Democratic presidential candidate Hillary Clinton at Eight Seven Central screen printers in Des Moines, Iowa, January 9, 2016. REUTERS/Brian C. Frank
Singer Katy Perry, center, holds a sign in support of Hillary Clinton, former U.S. secretary of state and 2016 Democratic presidential candidate, as Clinton speaks at the Jefferson-Jackson Dinner in Des Moines, Iowa, U.S., on Saturday, Oct. 24, 2015. With Vice President Joe Biden officially out of the presidential race, the nation's first nominating contest between front-runner Clinton and Senator Bernie Sanders is gaining steam, according to a new Bloomberg Politics/Des Moines Register Iowa Poll. Photographer: Daniel Acker/Bloomberg via Getty Images
Senate Minority Leader Harry Reid, seen here working with Clinton when they were Senate colleagues, was an early supporter of the former secretary of state. (REUTERS/William Philpott WP/SV)
Actress Kerry Washington, seen here at a 30th anniversary presentation at the 2015 Film Independent Spirit Awards, is a Clinton supporter. (Adrees Latif / Reuters)
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Trump is keeping the race close thanks to male voters, who support him over Clinton by 51 percent to 35 percent. Voters would also rather invite Trump to a "backyard barbecue," with 47 percent wanting to eat burgers with Trump to 39 percent who'd like to grill with Clinton.
"This is a very tight race that will divide Democrats and Republicans, the young and the old, white, black and Hispanic voters — and husbands and wives — in the months ahead," assistant director of the Quinnipiac University Poll Tim Malloy said, according to the release.
The poll also found that Sen. Bernie Sanders holds a wider lead over Trump, 48 percent to 39 percent.
However, Sanders is far behind in both delegates and the popular vote, and is unlikely to overtake Clinton to capture the nomination. And the poll found Clinton still leads Sanders among Democratic voters, 53 percent to 39 percent.