Russ Krasnoff and Gary Foster at Krasnoff Foster Productions will also produce. Witherspoon's producing partner Bruna Papandrea will oversee for Type A and Erik Baiers will oversee for Universal.
Schumer's "Trainwreck" grossed $110 million domestically for Universal and raked in another $28 million internationally. Her original screenplay was nominated for a Writers Guild award.
Schumer is starring in Fox's untitled mother-daughter comedy opposite Goldie Hawn, scheduled for a Mother's Day weekend release on May 12, 2017. She's wrapped on Jason Dean Hall's PTSD drama "Thank You for Your Service" for Dreamworks.
Schumer's sketch comedy series "Inside Amy Schumer" is in its fourth season on Comedy Central.
Pacific Standard has been active in developing projects based on novels with female protagonists, including "Wild" and "Gone Girl," Jessica Knoll's "Luckiest Girl Alive" at Lionsgate, Gayle Tzemach Lemmon's "Ashley's War" at Fox 2000, Wall Street comedy "Opening Belle" at Warner Bros. and a Barbie doll origins movie at Bold Films.
RELATED: Amy Schumer through her career
Amy Schumer through her career
Amy Schumer joins bachelor party comedy 'Who Invited Her?'
SANTA MONICA, CA - JANUARY 17: Actress-writer Amy Schumer accepts Critics' Choice MVP Award onstage during the 21st Annual Critics' Choice Awards at Barker Hangar on January 17, 2016 in Santa Monica, California. (Photo by Kevin Winter/Getty Images)
BEVERLY HILLS, CA - JANUARY 10: In this handout photo provided by NBCUniversal, Presenters Amy Schumer and Jennifer Lawrence speak onstage during the 73rd Annual Golden Globe Awards at The Beverly Hilton Hotel on January 10, 2016 in Beverly Hills, California. (Photo by Paul Drinkwater/NBCUniversal via Getty Images)
BEVERLY HILLS, CA - JANUARY 10: Amy Schumer arrives at the 73rd Annual Golden Globe Awards at The Beverly Hilton Hotel on January 10, 2016 in Beverly Hills, California. (Photo by Steve Granitz/WireImage)
WATCH WHAT HAPPENS LIVE -- Pictured: Amy Schumer -- (Photo by: Charles Sykes/Bravo/NBCU Photo Bank via Getty Images)
Comedian Amy Schumer performs at Glamour's presentation of 'These Girls' at Joe's Pub on May 20, 2013 in New York City. (Photo by Astrid Stawiarz/Getty Images for Glamour)
Comedian Amy Schumer performs on stage at 'Comedy Central's Stars Under the Stars' at Central Park SummerStage on June 26, 2013 in New York City. (Photo by Neilson Barnard/Getty Images for Comedy Central)
Comedian Amy Schumer attends the 'Anchorman 2: The Legend Continues' premiere, sponsored by Buffalo David Bitton, on December 15, 2013 in New York City. (Photo by Cindy Ord/Getty Images for Buffalo David Bitton)
Comedian Amy Schumer attends the 'Girls' season three premiere at Jazz at Lincoln Center on January 6, 2014 in New York City. (Photo by Andrew H. Walker/Getty Images)
Honoree Amy Schumer accepts the Breakthrough Award for Comedy onstage at the Variety Breakthrough of the Year Awards during the 2014 International CES at The Las Vegas Hotel & Casino on January 9, 2014 in Las Vegas, Nevada. (Photo by Jeff Bottari/Getty Images for Variety)
Comedian Amy Schumer speaks onstage at NRDC's 'Night Of Comedy' benefiting the Natural Resources Defense Council at 583 Park Ave on November 5, 2014 in New York City. (Photo by Bryan Bedder/Getty Images for NRDC)
Actress/comedian Amy Schumer poses for a photo at the book signing for her book 'Not That Kind of Girl: A Young Woman Tells You What She's 'Learned' at Barnes & Noble Union Square on September 30, 2014 in New York City. (Photo by J. Countess/Getty Images)
Amy Schumer attends the Glamour 2014 Women Of The Year Awards at Carnegie Hall on November 10, 2014 in New York City. (Photo by Dimitrios Kambouris/Getty Images for Glamour)
Comedian Amy Schumer attends GQ and LeBron James Celebrate All-Star Style on February 14, 2015 in New York City. (Photo by Jamie McCarthy/Getty Images for GQ)
Comedian Amy Schumer arrives for the GQ Men of the Year Party, at Chateau Marmont in West Hollywood, California, on December 4, 2014. (Photo by Robyn Beck/AFP/Getty Images)
Amy Schumer attends Comedy Central Night Of Too Many Starts at Beacon Theatre on February 28, 2015 in New York City. (Photo by Stephen Lovekin/Getty Images for Comedy Central)
Amy Schumer performs onstage at Comedy Central Night Of Too Many Stars at Beacon Theatre on February 28, 2015 in New York City. (Photo by Mike Coppola/Getty Images for Comedy Central)
Actress Amy Schumer (L) and producer Kim Caramele arrive at the screening of 'Trainwreck' during the 2015 SXSW Music, Film + Interactive Festival at the Paramount on March 15, 2015 in Austin, Texas. (Photo by Michael Buckner/Getty Images)
Host Amy Schumer attends The 2015 MTV Movie Awards at Nokia Theatre L.A. Live on April 12, 2015 in Los Angeles, California. (Photo by Rich Polk/Getty Images for MTV)
Amy Schumer poses for a photo in the press room during the 2015 MTV Movie Awards on April 12, 2015 in Los Angeles, California. (Photo by Frederic J. Brown/AFP/Getty Images)
Actress Amy Schumer speaks at Tribeca Talks: After the Movie: Inside Amy Schumer during the 2015 Tribeca Film Festival at Spring Studio on April 19, 2015 in New York City. (Photo by Robin Marchant/Getty Images for the 2015 Tribeca Film Festival)
Honoree and Comedian Amy Schumer pretends to trip and fall on the floor in front of honorees Kim Kardashian (2nd-L) and Kanye West (L) as they attend the Time 100 Gala celebrating the Time 100 issue of the Most Influential People at The World at Jazz at Lincoln Center on April 21, 2015 in New York.(Photo by Timothy A. Clary/AFP/Getty Images)
Comedian Amy Schumer speaks onstage at Universal Pictures Invites You to an Exclusive Product Presentation Highlighting its Summer of 2015 and Beyondat The Colosseum at Caesars Palace during CinemaCon, the official convention of the National Association of Theatre Owners, on April 23, 2015 in Las Vegas, Nevada. (Photo by Michael Buckner/Getty Images for CinemaCon)
Actress Amy Schumer accepts the 'CinemaCon Breakthrough Performer of the Year Award' onstage at The CinemaCon Big Screen Achievement Awards Brought to you by The Coca-Cola Company at The Colosseum at Caesars Palace during CinemaCon, the official convention of the National Association of Theatre Owners, on April 23, 2015 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images for CinemaCon)