Rosie O'Donnell on Donald Trump: 'Do not give up, he will never be president'

Rosie O'Donnell, patient-zero in Donald Trump's public feuds, couldn't resist taking a swing at the presumptive Republican presidential nominee on Monday night.

At a SAG panel with fellow actresses June Squibb and Linda Lavin, O'Donnell was explaining her role as Allison Janney's ex-lover on the CBS comedy "Mom," when she appeared to slip in a Trump insult.

"I've admired [Allison Janney] for so long, " O'Donnell said. "Being a lesbian in real life — news flash — get off your Twitter sir — don't tell people. ... It is not about politics it is about acting — lots of women around that house, too — I'm not going near him, trust me — Orange man. Anyway, the thing is, fin, his mouth looks like an anus. What I'm trying to say about 'Mom' is that everyone was really warm and lovely. But being that I am gay, I didn't want to be pushing the kiss part."

See photos of Rosie O'Donnell through the years:

The comedian's comment was the latest in a back-and-forth with Trump dating to 2006, when O'Donnell first blasted the billionaire on "The View." The feud has persisted for a decade, and came up last summer at the Republican debate. Just days ago, Trump said of O'Donnell, "Who the hell wouldn't speak badly about Rosie O'Donnell? She's terrible. She's terrible."

Speaking to Variety, O'Donnell seemed to assure fans she's not putting the tabloid-war to rest anytime soon and will continue to rail against Trump, which she has done actively on Twitter. "I believe in the innate humanity and sensible nature of Americans," O'Donnell said. "Do not give up, he will never be president."

See photos of Donald Trump's recent "TODAY" Show appearance: