"Glenn fought a courageous battle for the past several weeks but, sadly, succumbed to complications from Rheumatoid Arthritis, Acute Ulcerative Colitis and Pneumonia," read the statement. "Words can neither describe our sorrow, nor our love and respect for all that he has given to us, his family, the music community & millions of fans worldwide."
Frey had been battling intestinal issues that caused the band to postpone its Kennedy Center Honors award. A statement from the band said then the recurring problem would require "major surgery and a lengthy recovery period."
See photos of Glenn Frey throughout his career:
Eagles drummer and vocalist Don Henley issued the following statement:
"He was like a brother to me; we were family, and like most families, there was some dysfunction. But, the bond we forged 45 years ago was never broken, even during the 14 years that the Eagles were dissolved. We were two young men who made the pilgrimage to Los Angeles with the same dream: to make our mark in the music industry — and with perseverance, a deep love of music, our alliance with other great musicians and our manager, Irving Azoff, we built something that has lasted longer than anyone could have dreamed. But, Glenn was the one who started it all. He was the spark plug, the man with the plan. He had an encyclopedic knowledge of popular music and a work ethic that wouldn't quit. He was funny, bullheaded, mercurial, generous, deeply talented and driven. He loved is wife and kids more than anything. We are all in a state of shock, disbelief and profound sorrow. We brought our two-year 'History of the Eagles Tour' to a triumphant close at the end of July and now he is gone. I'm not sure I believe in fate, but I know that crossing paths with Glenn Lewis Frey in 1970 changed my life forever, and it eventually had an impact on the lives of millions of other people all over the planet. It will be very strange going forward in a world without him in it. But, I will be grateful, every day, that he was in my life. Rest in peace, my brother. You did what you set out to do, and then some."
Remember the stars we lost in 2015:
More from Billboard:
"American Pie" singer Don McLean arrested on domestic assault charges
Diane Warren responds to Linda Perry's claim that Lady Gaga didn't write "Til It Happens to You"
David Bowie scores his first No. 1 album in the U.S.