In November, the sitcom star revealed to Matt Lauer on NBC's "Today" that he was diagnosed with HIV four years ago. During his appearance, he said that doctors found an undetectable amount of the virus in his blood. However, two months later, Sheen told Dr. Oz that he received some terrible news before stepping onto the stage.
See more of Sheen through the years:
Charlie Sheen through the years
Charlie Sheen quits HIV meds, says he was 'born dead'
Charlie Sheen, 1984. (Photo by Getty Images)
Charlie Sheen in a scene from the film 'Platoon', 1986. (Photo by Orion/Getty Images)
CLEVELAND - JULY 1: Actor Charlie Sheen in town to promote the movie 'Major League' prior to an Indians game at the Cleveland Municipal Stadium on July 1, 1988 in Cleveland, Ohio . (Photo by Janet Macoska/Michael Ochs Archives/Getty Images)
Kelly Preston and Charlie Sheen at the Fox Theater in Westwood, California (Photo by Ron Galella, Ltd./WireImage)
Charlie Sheen and Michael Biehn in publicity portrait for the film 'Navy Seals', 1990. (Photo by Orion/Getty Images)
HOLLYWOOD - SEPTEMBER 24: Actor Charlie Sheen attends Charlie Sheen Hollywood Walk of Fame Ceremony on September 24, 1994 at the Hollywood Walk of Fame in Hollywood, California. (Photo by Ron Galella, Ltd./WireImage)
THE TONIGHT SHOW WITH JAY LENO -- Episode 4599 -- Pictured: (l-r) Actor Charlie Sheen during an interview with host Jay Leno on January 22, 2014 -- (Photo by: Paul Drinkwater/NBC/NBCU Photo Bank via Getty Images)
UNIVERSAL CITY, CA - MAY 12: Charlie Sheen visits 'Extra' at Universal Studios Hollywood on May 12, 2015 in Universal City, California. (Photo by Noel Vasquez/Getty Images)
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"I'm a little off my game, because right before I walked out here, I got some results that I was disappointed about," he said. "I know this is an experiment, that I took a stroll down a different path. But yeah, I'd been non-detectable and non-detectable and checking the blood every week, and then found out that the numbers were back up."