"I have determined that Jeb Bush is the most qualified. Jeb has the proven leadership skills and executive experience needed to fix the problems facing our country - from the anemic economy to America's weakened standing among world leaders," Dole further explained in a statement released by the Bush campaign.
Dole has a storied relationship with the Bush family.
He ran against Bush's father, George H.W. Bush, not once but twice, seeking the Republican nomination in 1980 and 1988. In 1996, when he finally won the nod, he ran against Bill Clinton -- the husband of likely 2016 Democratic nominee Hillary Clinton.
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Bob Dole endorses Jeb Bush
NORTH CHARLESTON, SC - JANUARY 15: Former Republican presidential candidate and South Carolina Sen. Lindsey Graham (R) announces his endorsement of Jeb Bush for president on January 15, 2016 in North Charleston, South Carolina. Graham dropped his bid for the presidency last month. (Photo by Scott Olson/Getty Images)
NORTH CHARLESTON, SC - JANUARY 14: Republican presidential candidates (L-R) New Jersey Governor Chris Christie and Jeb Bush laugh during a commercial break during the Fox Business Network Republican presidential debate at the North Charleston Coliseum and Performing Arts Center on January 14, 2016 in North Charleston, South Carolina. The sixth Republican debate is held in two parts, one main debate for the top seven candidates, and another for three other candidates lower in the current polls. (Photo by Scott Olson/Getty Images)
GRINNELL, IA - JANUARY 12: Republican presidential candidate Jeb Bush greets people during a town hall at the Brownell's Firearms Manufacturing company on January 12, 2016 in Grinnell, Iowa. Bush continues his quest to become the Republican presidential nominee. (Photo by Joe Raedle/Getty Images)
WAUKESHA, WI - NOVEMBER 09: Wisconsin Governor Scott Walker (R) sits with Republican presidential candidate Jeb Bush (L) at La Casa de Esperanza during a campaign stop on November 9, 2015 in Waukesha, Wisconsin. Tomorrow Bush will participate in the third Republican presidential debate sponsored by Fox Business News and the Wall Street Journal at the Milwaukee Theater in nearby Milwaukee. (Photo by Scott Olson/Getty Images)
TAMPA, FL - NOVEMBER 2: Republican presidential candidate and former Florida governor Jeb Bush allows a supporter to loosen his necktie during a rally on his 'Jeb Can Fix It' Tour on November 2, 2015 at the Tampa Garden Club in Tampa, Florida. Following dropping poll numbers and poor debate performance Bush is trying to reset his campaign that many say has been flailing. (Photo by Brian Blanco/Getty Images)
DES MOINES, IA - AUGUST 14: Republican presidential hopeful and former Florida Gov. Jeb Bush (R) and Iowa Gov. Terry Branstad eat a pork chop on a stick at the Iowa Pork Tent during the Iowa State Fair on August 14, 2015 in Des Moines, Iowa. Presidential candidates are addressing attendees at the Iowa State Fair on the Des Moines Register Presidential Soapbox stage. The State Fair runs through August 23. (Photo by Justin Sullivan/Getty Images)
DES MOINES, IA - AUGUST 14: Republican presidential hopeful and former Florida Gov. Jeb Bush (C) talks with members of the media as U.S. Sen. Chuck Grassley (L) (R-IA) and U.S. Sen. Joni Ernst (R) (R-IA) look on during the Iowa State Fair on August 14, 2015 in Des Moines, Iowa. Presidential candidates are addressing attendees at the Iowa State Fair on the Des Moines Register Presidential Soapbox stage. The State Fair runs through August 23. (Photo by Justin Sullivan/Getty Images)
MIAMI, FL - JUNE 15: Former Florida Governor Jeb Bush waves on stage as he announces his candidacy for the Republican presidential nomination during an event at Miami-Dade College - Kendall Campus on June 15 , 2015 in Miami, Florida. Bush joins a list of Republican candidates to announce their plans on running against the Democrats for the White House. (Photo by Joe Raedle/Getty Images)
MYRTLE BEACH, SC - MARCH 18: Former Florida Governor and potential Republican presidential candidate Jeb Bush kisses a supporter during an early morning GOP breakfast event on March 18, 2015 in Myrtle Beach, South Carolina. Bush announced in December that he 'actively explore' a presidential run in 2016. He is currently on a two day tour through South Carolina and will attend several fundraising events. (Photo by Richard Ellis/Getty Images)
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The 41st president, in a diary entry published in a new biography by Jon Meacham, once called Dole "a son of a bitch." Relations between the two men improved during the elder Bush's presidency.
The former WWII veteran was President George W. Bush's co-chair of the President's Commission on Care for America's Returning Wounded Warriors.
The endorsement of Dole, who has long been a fixture in Republican politics, is a stark contrast, however, to the younger generation of Republicans who have backed Sen. Marco Rubio, a candidate who has focused his entire campaign around being the next generation of Republican politics.