After his collection outgrew the space, famed architect Frank Lloyd Wright began to design the museum truly unlike any other.
"Entering into the spirit of this interior, you will discover the best possible atmosphere in which to show fine paintings or listen to music. It is this atmosphere that seems to me most lacking in our art galleries, museums, music halls and theaters."
Frank Lloyd Wright, Architectural Forum, 1948
Sadly, neither Guggenheim nor Wright lived to see the museum's opening; but their legacy continues to live on today as the museum is adored by millions.
Never been to the Guggenheim? Take a look through some of our favorite photos of the museum, courtesy of Instagrammers across the world:
See more unbelievable photos of the Guggenheim here:
Today in History: The Guggenheim opens in NYC
The Guggenheim Museum of Modern and Contempory Art in New York. (Photo by Sherman/Getty Images)
UNITED STATES - JANUARY 01: Guggenheim Museum By Night At New York In Usa-North America On 1959 (Photo by Keystone-France/Gamma-Keystone via Getty Images)
The Guggenheim Museum in New York City, glimpsed across the reflective surface of a car roof, 1961. (Photo by Ernst Haas/Hulton Archive/Getty Images)
UNITED STATES - APRIL 17: Overhead view of the nearly completed Solomon R. Guggenheim Museum created by architect Frank Lloyd Wright. (Photo by Frank Hurley/NY Daily News Archive via Getty Images)
UNITED STATES - OCTOBER 20: Interior of Guggenheim Museum designed by Frank Lloyd Wright. (Photo by John Durpey/NY Daily News Archive via Getty Images)
NEW YORK - DECEMBER 3: Interior view of the Guggenheim Museum by Frank Lloyd Wright on December 3, 1979 in New York, New York. (Photo by Santi Visalli/Getty Images)
A woman viewing two of 'The Solomon R Guggenheim' series of fibreglass reliefs by British pop artist Richard Hamilton (1922 - 2011) at a preview of the first full retrospective exhibition of Hamilton's work at the Tate Gallery (now Tate Britain), London, 11th March 1970. The works are part of a series of six made from 1965-66 and are based on designs by architect Frank Lloyd Wright. (Photo by Frank Barratt/keystone//Hulton Archive/Getty Images)
UNITED STATES - JANUARY 01: Guggenheim museum in New York. Photography. 1971. (Photo by Imagno/Getty Images) [Das Guggenheim-Museum in New York. Photographie. 1971.]
(GERMANY OUT) NEW YORK: GUGGENHEIM, 1993. The Guggenheim Museum, Fifth Avenue, New York. Photographed 1993. (Photo by Katharina Hoppe/ullstein bild via Getty Images)
1961: The spiral interior of the Solomon R Guggenheim Museum in New York, designed by Frank Lloyd Wright. (Photo by Ernst Haas/Ernst Haas/Getty Images)