The Food Network star was recently re-admitted to the hospital for another surgery due to complications from her double mastectomy in May and she opened up to ET's Nancy O'Dell about the tough decision.
"I would make that decision again," Lee said of her surgery. "Absolutely, even given the complications and the secondary infection. There is no question in my mind. [I'm] relieved that there is no cancer left in my body and I just want to move on with my life."
Lee also revealed that her longtime boyfriend, New York Governor Andrew Cuomo, has been her rock throughout her battle with cancer and recovery from the mastectomy.
"He was the last person that I saw before I went out [for surgery]," she recalled. "He was in his scrubs, I was in my scrubs."
Photos of Sandra Lee from over the years:
Sandra Lee opens up about battling breast cancer: 'I just want to move on with my life'
LOS ANGELES, CA - SEPTEMBER 20: Chef Sandra Lee attends the 67th Annual Primetime Emmy Awards at Microsoft Theater on September 20, 2015 in Los Angeles, California. (Photo by Frazer Harrison/Getty Images)
NEW YORK, NY - AUGUST 12: Governor Andrew Cuomo and Sandra Lee leave Mount Sinai Roosevelt Hospital on August 12, 2015 in New York City. (Photo by James Devaney/GC Images)
NEW YORK, NY - MARCH 18: Chef Sandra Lee attends the 'Danny Collins' New York premiere at AMC Lincoln Square Theater on March 18, 2015 in New York City. (Photo by Jamie McCarthy/Getty Images)
Update: Sandra says that waking up is the toughest part of the day. #BreastCancerAwareness http://t.co/czGZsc7t5e
Update: Day three was harder on Sandra. The nurses call it the "hit by a truck" day. #breastcancerawareness http://t.co/79u0dUxN6a
1 small step for Sandra, one giant step for all women who have been impacted by breast cancer. #BreastCancerAwareness http://t.co/QQNd3SfaZv
I woke up to a gorgeous bouquet from my college roommate! She knows I love white flowers. 💐
By my side ❤️
MT KISCO, NY - MAY 25: Sandra Lee returns to her home in Mount Kisco, New York after checking out of New York City hospital on May 25, 2015. (Photo by James Devaney/GC Images)
NEW YORK, NY - APRIL 22: Honoree Sandra Lee speaks on stage during the 2015 Housing Works Groundbreaker Awards at Metropolitan Pavilion on April 22, 2015 in New York City. (Photo by Gary Gershoff/Getty Images for Housing Works)
NEW YORK, NY - NOVEMBER 27: Chef Sandra Lee attends the 88th Annual Macy's Thanksgiving Day Parade on November 27, 2014 in New York City. (Photo by Michael Stewart/Getty Images)
NEW YORK, NY - NOVEMBER 04: Gov. Andrew Cuomo, Sandra Lee and family on stage after Andrew Cuomo won re-election for a second term, at the Sheraton on November 4, 2014 in New York City. (Photo by Steve Sands/Getty Images)
MT KISCO, NY - NOVEMBER 04: New York State Governor, Andrew Cuomo (R), speaks while his girlfriend, television personality Sandra Lee, looks on during the 2014 general election at the Presbyterian Church of Mount Kisco on November 4, 2014 in Mt Kisco, New York. (Photo by Kenneth Gabrielsen/Getty Images)
Sandra Lee (L) and actress Judith Light arrive to attend the Elton John AIDS Foundation's 13th Annual An Enduring Vision Benefit on October 28, 2014 in New York. AFP PHOTO/Jewel Samad (Photo credit should read JEWEL SAMAD/AFP/Getty Images)
NEW YORK, NY - SEPTEMBER 11: New York Governor Andrew Cuomo (L) and and his girlfriend Sandra Lee talk during memorial observances held at the site of the World Trade Center on September 11, 2014 in New York City. This year marks the 13th anniversary of the September 11th terrorist attacks that killed nearly 3,000 people at the World Trade Center, Pentagon and on Flight 93. (Photo by Mark Lennihan-Pool/Getty Images)
NEW YORK, NY - MAY 05: Sandra Lee attends the 'Charles James: Beyond Fashion' Costume Institute Gala at the Metropolitan Museum of Art on May 5, 2014 in New York City. (Photo by Larry Busacca/Getty Images)
NEW YORK, NY - APRIL 25: TV Personality Sandra Lee attends the 2014 Variety Power Of Women: New York Luncheon at Cipriani 42nd Street on April 25, 2014 in New York City. (Photo by Desiree Navarro/WireImage)
NEW YORK, NY - OCTOBER 15: Sandra Lee attends the Elton John AIDS Foundation's 12th Annual An Enduring Vision Benefit at Cipriani Wall Street on October 15, 2013 in New York City. (Photo by D Dipasupil/FilmMagic)
TODAY -- Pictured: (l-r) Savannah Guthrie and Sandra Lee appear on NBC News' 'Today' show -- (Photo by: Peter Kramer/NBC/NBC NewsWire via Getty Images)
LOS ANGELES, CA - SEPTEMBER 22: Sandra Lee arrives at the 65th Annual Primetime Emmy Awards at Nokia Theatre L.A. Live on September 22, 2013 in Los Angeles, California. (Photo by Jon Kopaloff/FilmMagic)
LATE NIGHT WITH JIMMY FALLON -- Episode 816 -- Pictured: (l-r) Sandra Lee with host Jimmy Fallon on April 10, 2013 -- (Photo by: Lloyd Bishop/NBC/NBCU Photo Bank via Getty Images)
WEST HOLLYWOOD, CA - FEBRUARY 24: TV personality Sandra Lee attends the 21st Annual Elton John AIDS Foundation Academy Awards Viewing Party at West Hollywood Park on February 24, 2013 in West Hollywood, California. (Photo by Jason Kempin/Getty Images for EJAF)
NEW YORK, NY - APRIL 24: Sandra Lee attends the TIME 100 Gala, TIME'S 100 Most Influential People In The World, cocktail party at Jazz at Lincoln Center on April 24, 2012 in New York City. (Photo by Fernando Leon/Getty Images for TIME)
Lee told O'Dell that the hospital wanted to wheel her in for surgery on a gurney, but the celebrity chef refused.
"I just said no. I am walking in there. I am doing this. I am not going to let cancer or any diagnosis defeat me or my spirit," she said. "And he said 'OK, we are doing this'."
"He said, 'You are good, I love you. I will be here when you wake up'," Lee told O'Dell of Cuomo's supportive words.
The Semi-Homemade star got visibly emotional at the memory, jokingly blaming Cuomo for her tears.
"The only one that makes me cry is him," she laughed. "Nothing else makes me cry. Isn't that amazing? He is so sweet."
Lee spoke to ET at Sunday's Emmy Awards about author Jackie Collins, who passed away recently after a battle with breast cancer. See what the celebrity chef had to say about the Collins in the video blow.