While she'll likely change the tone of the debate from a policy perspective -- and as a likely critic of Donald Trump -- history has often shown that the mere introduction of a woman into a political debate changes how the usual barbs and jabs are received.
From when Geraldine Ferraro faced off against George H.W. Bush in the 1980s to when Sarah Palin and Joe Biden went head-to-head in 2008, check out the video above to see some of the many ways women hold their own and stand their ground on the debate stage.
See Fiorina on the campaign trail:
Carly Fiorina on the campaign trail
How Carly Fiorina may change the 2nd GOP debate
DAVENPORT, IA - SEPTEMBER 25: Republican presidential candidate Carly Fiorina addresses the Quad Cities New Ideas Forum at St. Ambrose University on September 25, 2015 in Davenport, Iowa. Fiorina is currently polling in second place behind Donald Trump for the Republican nomination. (Photo by Scott Olson/Getty Images)
MYRTLE BEACH, SC - SEPTEMBER 22: Republican presidential candidate Carly Fiorina speaks to voters during a town hall meeting at the Ocean Reef Convention Center September 22, 2015 in Myrtle Beach, South Carolina. Fiorina is a former Chief Executive Officer of Hewlett-Packard and currently chairs the non-profit philanthropic organization Good360. (Photo by Sean Rayford/Getty Images)
THE TONIGHT SHOW STARRING JIMMY FALLON -- Episode 0333 -- Pictured: (l-r) Politician Carly Fiorina during an interview with host Jimmy Fallon on September 21, 2015 -- (Photo by: Douglas Gorenstein/NBC/NBCU Photo Bank via Getty Images)
GREENVILLE, SC - SEPTEMBER 18: Republican presidential candidate Carly Fiorina speaks to voters at the Heritage Action Presidential Candidate Forum September 18, 2015 in Greenville, South Carolina. Ten republican candidates were each given 25 minutes to talk to the crowd at the Bons Secours Wellness Arena in the upstate of South Carolina. (Photo by Sean Rayford/Getty Images)
Republican presidential hopeful Carly Fiorina looks on during the Republican presidential debate at the Ronald Reagan Presidential Library in Simi Valley, California on September 16, 2015. Republican presidential frontrunner Donald Trump stepped into a campaign hornet's nest as his rivals collectively turned their sights on the billionaire in the party's second debate of the 2016 presidential race. AFP PHOTO / FREDERIC J. BROWN (Photo credit should read FREDERIC J BROWN/AFP/Getty Images)
DERRY, NH - SEPTEMBER 6: Republican presidential candidate Carly Fiorina campaigns in New Hampshire over Labour Day weekend and meets with locals at MaryAnn's Diner on September 6, 2015 in Derry, New Hampshire. (Photos by Charles Ommanney/The Washington Post via Getty Images)
LITTLETON, NEW HAMPSHIRE - AUGUST 20: Carly Fiorina meets New Hampshire voters at a Spaghetti Dinner in the north country of Littleton, New Hampshire on Thursday, August 20, 2015. (Photo by Melina Mara/The Washington Post via Getty Images)