Researchers from Johns Hopkins announced a breakthrough in ALS research, and gave thanks to the Ice Bucket Challenge.
Back when this was all over your Facebook, a lot of people said it wasn't going to do any good.
But $220M later, some Johns Hopkins ALS researchers have a message.
"We've recently made a big breakthrough for ALS..."
In a Reddit AMA, the researchers wrote, "I remember reading a lot of stories about people complaining that the ice bucket challenge was a waste and that scientists weren't using the money to do research, etc. I assure you that this is absolutely false."
"There's this protein called TDP-43 that doesn't seem to be doing its job in the neurons of ALS patients, and for the past decade we've been trying to figure out exactly what it's doing. And now I think we finally figured it out, and the best part is it can be fixed."
The study was published in the journal Science. "Of course, there is always more to be done so please consider donating."
See more on ALS fundraising and the man who started it all, Pete Frates:
Pete Frates and ALS fundraising
ALS researchers to haters: The Ice Bucket Challenge worked
NEW YORK, NY - DECEMBER 09: Pete Frates and Julie Frates attend the Sportsman Of The Year 2014 Ceremony on December 9, 2014 in New York City. (Photo by Rob Kim/Getty Images for Sports Illustrated)
BOSTON, MA - APRIL 13: New England Patriots quarterback Tom Brady talks with Pete Frates and his wife Julie Frates at Fenway Park on April 13, 2015 in Boston, Massachusetts. (Photo by Maddie Meyer/Getty Images)
BOSTON, MA - APRIL 13: Pete Frates is signed to the Boston Red Sox by Red Sox general manager Ben Cherington at Fenway Park on April 13, 2015 in Boston, Massachusetts. (Photo by Maddie Meyer/Getty Images)
Team members pour ice cold water onto Mercedes-AMG's British driver Lewis Hamilton as he takes the 'Ice Bucket Challenge' to raise awareness about ALS (Amyotrophic lateral sclerosis) at the Spa-Francorchamps circuit in Spa on August 22, 2014 ahead of the Belgium Formula One Grand Prix. AFP PHOTO / BELGA PHOTO / NICOLAS LAMBERT ** BELGIUM OUT ** (Photo credit should read NICOLAS LAMBERT/AFP/Getty Images)
Former Thai prime minister Abhisit Vejjajiva braves the 'Ice Bucket Challenge' to raise awareness of amyotrophic lateral sclerosis at the Thai Red Cross Society in Bangkok on August 22, 2014. Numerous people including many celebrities have taken part around the world in recent weeks in the challenge to raise awareness of the disease that targets the nerve cells in the brain and spinal cord. AFP PHOTO / PORNCHAI KITTIWONGSAKUL (Photo credit should read PORNCHAI KITTIWONGSAKUL/AFP/Getty Images)
NEW YORK - JULY 04: Michael Goldsmith, a sufferer of Amyotrophic Lateral Sclerosis (ALS), often referred to as 'Lou Gehrig's Disease' watches an onscreen presentation with son, Austin, prior to the game between the New York Yankees and the Toronto Blue Jays on July 4, 2009 at Yankee Stadium in the Bronx borough of New York City. (Photo by Nick Laham/Getty Images)
COLOGNE, GERMANY - DECEMBER 07: Barbara Schoeneberger and TV host Guenther Jauch take part in the 'Ice Bucket Challenge' during the 2014! Menschen, Bilder, Emotionen - RTL Jahresrueckblick show on December 7, 2014 in Cologne, Germany. (Photo by Andreas Rentz/Getty Images)
WASHINGTON, DC - AUGUST 22: Manager Bruce Bochy #15 of the San Francisco Giants takes the ALS Ice Bucket Challenge after the game against the Washington Nationals at Nationals Park on August 22, 2014 in Washington, DC. (Photo by Greg Fiume/Getty Images)