In addition to her impressive humanitarian efforts, Jolie earned widespread praise for using her personal health condition to shed light on an alarmingly common issue. Angelina inspired millions to get serious about personal health as a result of her 2014 preventative mastectomy and subsequent ovarian and fallopian tube removal this year due to a defective genome. Many have credited her for stirring discussion about the pros and cons of preventative surgeries for women prone to breast cancer.
"Regardless of the hormone replacements I'm taking, I am now in menopause. I will not be able to have any more children, and I expect some physical changes...I feel deeply for women for whom this moment comes very early in life, before they have had their children. Their situation is far harder than mine."
Jolie's advocacy for women with cancer or defective genes, her activism regarding issues with the U.N. Security Council, her philanthropic projects, and her incredible film career has made her one of the world's most powerful women.
To top it all off, she somehow manages to mother six children with husband Brad Pitt. If anyone deserves a special birthday celebration, it's Angelina Jolie. Happy birthday Angelina!
Click through this slideshow to see pictures of Angelina Jolie conquering her incredible career throughout the years:
Angelina Jolie through the years
Angelina Jolie celebrates 40 years of empowerment
American actor Angelina Jolie attends an event wearijg a strapless black gown, New York City, circa 1998. (Photo by Victor Malafronte/Getty Images)
LOS ANGELES, UNITED STATES: Actress Angelina Jolie kisses her Oscar at the Academy Awards in Los Angeles 26 March 2000. Jolie won for Best Supporting Actress for her role in 'Girl Interupted'. (ELECTRONIC IMAGE) AFP PHOTO/SCOTT NELSON (Photo credit should read Scott Nelson/AFP/Getty Images)
Cast member Angelina Jolie and husband Billy Bob Thornton before the 'Original Sin' premiere held at DGA Theater in Los Angeles, CA., Tues., July 31, 2001. (photo by Kevin Winter/Getty Images)
Angelina Jolie arrives for the premiere of the film 'Lara Croft: Tomb Raider' at Mann Village Theatre in Los Angeles, CA., Monday, June 11, 2001. (photo by Kevin Winter/Getty Images)
BEVERLY HILLS, UNITED STATES: US actor Billy Bob Thornton (R) and his wife, actress Angelina Jolie, arrive at the 59th Annual Golden Globe Awards in Beverly Hills 20 January 2002. Thornton is nominated for Best Actor-Motion Picture Drama for his role in 'Monster's Ball.' AFP PHOTO/Lucy Nicholson (Photo credit should read LUCY NICHOLSON/AFP/Getty Images)
WASHINGTON - JUNE 20: Actress Angelina Jolie, Goodwill Ambassador for the United Nations High Commission for Refugees (UNHCR), participates in a World Refugee Day ceremony June 20, 2003 in Washington, DC. World Refugee Day celebrates the lives of the eight million refugee youths who live around the world. (Photo by Stefan Zaklin/Getty Images)
HOLLYWOOD, CA - FEBRUARY 29: Actress Angelina Jolie attends the 76th Annual Academy Awards at the Kodak Theater on February 29, 2004 in Hollywood, California. (Photo by Carlo Allegri/Getty Images)
LOS ANGELES - MARCH 16: Actress Angelina Jolie arrives for the world premiere of her film 'Taking Lives' March 16, 2004 in Los Angeles, California. (Photo by Carlo Allegri/Getty Images)
BURBANK, CA - MARCH 16: Actress Angelina Jolie appears on 'The Tonight Show with Jay Leno' at the NBC Studios on March 16, 2004 in Burbank, California. (Photo by Kevin Winter/Getty Images)
VENICE, ITALY - SEPTEMBER 10: Actress Angelina Jolie and her son Maddox attend the World Premiere of 'Shark Tale' in San Marco Square, as part of the 61st Venice Film Festival on September 10, 2004 in Venice, Italy. (Photo by Pascal Le Segretain/Getty Images)
WESTWOOD, CA - JUNE 07: Actress Angelina Jolie arrives at the premiere of 'Mr. & Mrs. Smith' at the Mann Village Theater on June 7, 2005 in Westwood, California. (Photo by Kevin Winter/Getty Images)
JABEL SHAROON, PAKISTAN - NOVEMBER 26: In this handout photo supplied by the United Nations High Commission for Refugees (UNHCR), UNHCR Goodwill Ambassador Angelina Jolie listens as a local woman in this village 6,000 feet above sea level in Pakistan-administered Kashmir, tells a UNHCR worker about her preparations for the coming winter, which includes salvaging materials from the remains of houses after the earthquake, November 26, 2005 in Jabel Sharoon, Pakistan. (Photo by J Redden/UNHCR via Getty Images)
Hollywood movie stars Brad Pitt (C) and his partner Angelina Jolie ride on a motorcycle on a busy street in downtown Ho Chi Minh city, 23 November 2006. Jolie, the partner of fellow screen idol Brad Pitt, was expected to adopt a three-year-old Vietnamese boy 15 March 2007, according to the head of the Tam Binh orphanage, from where the child is. AFP PHOTO/FILES (Photo credit should read STR/AFP/Getty Images)
HOLLYWOOD - JUNE 05: Actress Angelina Jolie and actor Brad Pitt arrive to the Warner Bros. premiere of the film 'Ocean's 13' at Grauman's Chinese Theatre on June 5, 2007 in Hollywood, California. (Photo by Kevin Winter/Getty Images)
CANNES, FRANCE - MAY 20: Producer Brian Grazer, actors Angelina Jolie and Brad Pitt arrives for the 'Changeling' Premiere at the Palais des Festivals during the 61st International Cannes Film Festival on May 20, 2008 in Cannes, France. (Photo by Kristian Dowling/Getty Images)
NEW YORK, NY - APRIL 24: United Nations High Commissioner for Refugees Antonio Guterres is seated to the left of actress/activist Angelina Jolie as she speaks at a United Nations Security Council Meeting on the situation in the Middle East and Syria at the United Nations on April 24, 2015 in New York City. (Photo by Jemal Countess/Getty Images)
INGLEWOOD, CA - MARCH 28: Actress Angelina Jolie hugs Zahara Marley Jolie-Pitt (L) and Shiloh Nouvel Jolie-Pitt (R) after winning award for Favorite Villain in 'Maleficent' during Nickelodeon's 28th Annual Kids' Choice Awards held at The Forum on March 28, 2015 in Inglewood, California. (Photo by Kevin Winter/Getty Images)