Pulling off a stunt that only Bill Murray could get away with, the comedian emerged from the cake and fell to the ground before wrapping Letterman in an icing-covered bear hug.
David Letterman, Late Night, through the years
Bill Murray pops out of a cake as he says goodbye to David Letterman
NEW YORK, UNITED STATES: US Vice President and Democratic presidential candidate Al Gore (R) with talk show host David Letterman 14 September, 2000 after the taping of Letterman's show at the Sullivan Theater in New York City. AFP PHOTO/ Luke FRAZZA (Photo credit should read LUKE FRAZZA/AFP/Getty Images)
NEW YORK, UNITED STATES: Republican presidental candidate and Texas Governor George W. Bush (L) poses for photographers with David Letterman after concluding taping of the 19 October 2000 Late Show with David Letterman in New York. Bush read the Top Ten list poking fun at what he might do if elected. AFP Photo by Paul J. RICHARDS (Photo credit should read PAUL J. RICHARDS/AFP/Getty Images)
BAGHDAD, IRAQ - DECEMBER 24: In this handout photo provided by the U.S. Air Force, 'Late Show' television host David Letterman entertains soldiers at the Coalition Provisional Authority headquarters December 24, 2003 in Baghdad, Iraq. (Photo by Reynaldo Ramon/U.S. Air Force via Getty Images)
NEW YORK - MAY 7: Tina Fey takes off her dress after her last appearance on the CBS Late Show with David Letterman, Thursday May 7, 2015 on the CBS Television Network (Photo by John Paul Filo/CBS via Getty Images)
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The comedian, who appeared on Letterman's first Late Show in August 1993, then walked into the crowd, smearing cake and icing on a few audience members and even offering a messy fist bump to Letterman's bandleader Paul Shaffer.
David Letterman's final episode of The Late Show, which is being billed as "an hour filled with surprises, memorable highlights, the show's final Top Ten List and more," airs Wednesday, May 20 on CBS.