It's hard to believe that George Clooney made his acting debut on "ER" in 1978 -- and even harder to believe it's been nearly 30 years since John Stamos stole our hearts on "Full House."
Both men haven't seemed to age a day in the past few decades, and they're among a gorgeous group of stars who look even better over the age of 50.
Whether you believe in lucky genes, the fountain of youth -- or good ol' Tinseltown docs, check out some of the sexiest, ageless Hollywood men in the gallery above.
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