Sanofi Ends Cancer and Coronary Drug Trials


Two phase 3 trials -- one for the cancer-fighting drug Iniparib and the other for Otamixaban, a therapy designed for use in treating coronary disease -- have been terminated due to a lack of results, Sanofiannounced today.

In the Iniparib study, newly diagnosed cell lung patients were treated with the drug in conjunction with chemotherapy. According to Sanofi, "There were no clinically meaningful differences in the main safety parameters," compared to patients who received chemotherapy alone. Ending development of Iniparib will result in a $235 million non-cash charge recognized on Sanofi's June 30, 2013 consolidated balance sheet.

The results for the anticoagulant Otamixaban were also unsuccessful and the drug did not "meet its primary endpoint of superiority over current therapy," according to Sanofi. Following the study, it was determined that the investigational program for Otamixaban will also be discontinued.


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