The Most Trustworthy Drugs on the Market


How much is trustworthiness actually worth? That somewhat strange thought entered my brain recently after reviewing the latest Harris Physician Pulse Survey. What I discovered in trying to answer my own question might be a little surprising.

Poll position
First, let's look at how the polling experts at Harris Interactive determined which brand drugs in several categories are most trusted by doctors. 1,034 physicians, including primary care physicians and specialists, were lined up to complete an online survey.

The survey included questions that addressed the perceived functional benefit of specific brand drugs, as well as physicians' familiarity and "emotional connection" with the drugs. Respondents were also asked about their views on the companies that made the drugs and the sales representatives with whom they interacted.

For this round of the survey, only drugs used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), osteoporosis, pregnancy prevention, and rheumatoid arthritis were included. All of the information was compiled into a score referred to as the Trust Index. The highest Trust Index score possible is 100, which would probably mean that doctors trusted the drug more than they did their own mothers. The lowest score is 0, which is perhaps a little higher than the trust level that most Americans have for politicians in Washington.

Survey says
The survey found that the most trusted drugs in the five categories included were:


Top Drug







Pfizer and Boehringer Ingelheim



Warner Chilcott

Pregnancy Prevention



Rheumatoid Arthritis

Enbrel /

Humira (tie)

Amgen and Pfizer


Source: Harris Interactive.

Harris Interactive discovered that physicians' connections with and their perception of the pharmaceutical companies and their representatives were as important as the functional attributes of the drugs. This implies that the reputations of the category leaders could help build trust with the companies' other products.

Analysis of the survey results also showed that the leading drugs had several characteristics in common. These commonalities included being perceived to have differentiating functional benefits and making an emotional connection with physicians. Another common denominator among the top-ranked drugs was that the pharmaceutical companies marketing the drugs were viewed by physicians as thought leaders in the industry.

The value of trust
It makes sense that a drug considered more trustworthy by physicians will be prescribed more by them. Therefore, the more trustworthy a drug is, the higher the sales should be for the drug. Does this line of reasoning hold up with the Harris Physician Pulse Survey?

To find out, I obtained 2012 actual sales results (or estimated results where full-year numbers weren't available) for the drugs included in the survey. Here's how the sales figures stack up against the Trust Index calculated from the survey.

Sources: Harris Interactive, company SEC filings,,

It isn't surprising that most of the category leaders -- Advair, Enbrel, Humira and Spiriva -- have both high Trust Index scores and high sales numbers. (Note that Glaxo's Advair appears twice because it is used as a treatment in two categories.) Bayer's Mirena was the top pregnancy prevention drug but didn't have nearly as high sales levels as the other leaders. However, that is to be expected for that particular market.

However, there are some outliers. For example, Roche's Rituxan had a Trust Index score of 73 -- lower than any other rheumatoid arthritis drug in the survey. However, sales for Rituxan were much higher than several drugs with higher trust scores. Also, while Humira and Enbrel tied with Trust Index scores of 83 each, AbbVie outsold rivals Amgen and Pfizer by more than 13% last year.

The osteoporosis category also has a few seeming anomalies. Warner Chilcott's Actonel scored 71 on the Trust Index, enough to lead in the category but lower than all drugs in the other categories. Evista and Forteo from Eli Lilly lagged Actonel by a couple of points on the trust score. However, both drugs achieved annual sales of over $1 billion -- more than double the sales recorded by Actonel.

Overall, though, higher trust scores generally corresponded to higher sales levels. That's just as we would expect.

How can this information help investors? Assuming the findings of the Harris survey are on target, pharmaceutical companies that forge strong connections with physicians can build higher levels of trust even if their drugs aren't necessarily viewed as the strongest. The companies with the highest Trust Index scores were Pfizer, AbbVie and Amgen. It's no accident that their drugs also boasted some of the strongest sales results. Each of these company's stocks are worthy of investors' consideration.

Of the three, I like AbbVie the most for 2013. The company has a forward price-to-earnings multiple of 11.4 and pays a nice dividend of 4.4%. Things might get dicey in the next few years, because Humira loses patent protection at the end of 2016. For now, though, my view is that AbbVie should rate as a trustworthy investment.

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Originally published