Is It A Mistake To Turn Down A Job Offer If You're Unemployed?

Lately I've received more calls than usual for job interviews. I'm very happy about this; but after one particularly promising interview today, I'm surprised that I'm also feeling a little unsettled.

I think this employer may be on the verge of making me a job offer.

You know how they say, "Be careful what you wish for?" I've been looking for a new job for almost three years now. So what's my problem? Maybe thoughts of a daily commute and working in an office again are making me anxious.