Has Botox jumped the shark?

Jennifer Aniston said she tried it once but didn't like how it made her face feel. Her BFF Courteney Cox Arquette felt the same way after one injection. And Oscar winner Kate Winslet has said she refuses to try it because she "wants to be able to really show the expressions" on her face.

What are these beautiful actresses talking about? Botox, of course. Could these women be the vanguard to a backlash against the nerve-freezing compound?

Figures for Botox did dip in 2009, according to the American Society of Plastic Surgeons (ASPS). In 2008, more than 5 million injections of botulinum toxin type A were performed, compared to 4,795,357 in 2009, a 4% drop. In contrast, minimally invasive procedures, which include Botox, increased by 1% in that same period.