Description:When Oprah was 6 years old, she was separated from her grandmother, who'd been her primary caregiver. It was a life transition that helped Oprah learn the powerful lesson she shares in this clip from "Oprah's Lifeclass": "You are responsible for your life." "I have always had the deep understanding for myself that if anything was going to move forward in my life that I was going to have to be responsible for making that happen," she says.(1:52)