Woman who received world's first face transplant dies at age 49

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In 2005, Isabelle Dinoire received the world's first face transplant after losing her nose, chin, and lips to an attack by a dog, reports The Guardian.

According to Gizmodo, it was announced on Tuesday that Dinoire, 49, passed away on April 22.

The cause was unspecified, though it was revealed she had been ill for some time.

See more photos of Isabelle:

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Isabelle Dinoire first person to receive a face transplant
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Isabelle Dinoire first person to receive a face transplant
Isabelle Dinoire, the woman who received the world's first partial face transplant with a new nose, chin and mouth, in an operation on Nov. 27, 2005, addresses reporters during her first press conference since the transplant at the Amiens hospital, northern France Monday Feb. 6, 2006. The 38-year-old woman was mauled by a dog in May, leaving her with severe facial injuries that her doctors said made it difficult for her to speak and eat. (AP Photo/Michel Spingler)
Isabelle Dinoire, center, the woman who received the world's first partial face transplant with a new nose, chin and mouth in a transplant operation on Nov. 27, 2005, addresses reporters with Dr Sophie Testelin, left, and Dr Sophie Cremades, right, during her first press conference since the transplant at Amiens hospital, northern France Monday Feb. 6, 2006. The 38-year-old woman was mauled by a dog in May, leaving her with severe facial injuries that her doctors said made it difficult for her to speak and eat. (AP Photo/Michel Spingler)
Amiens, FRANCE: Isabelle Dinoire, the woman who received the world's first facial face transplant last November in Amiens, northern France, holds a press conference 06 February 2006 at this town's hospital. French surgeons said they faced tough ethical questions when they performed the world's first partial face transplant on a 38-year-old woman, but decided to go ahead because it was the only way to help the patient. AFP PHOTO DENIS CHARLET (Photo credit should read DENIS CHARLET/AFP/Getty Images)
The photos of Isabelle Dinoire, the woman who received the world's first partial face transplant with part of a nose, chin and lips on Nov. 27, is seen on a screen during her first appearance at a press conference since the November surgery at the Amiens Hospital, northern France, Monday Feb. 6, 2006. The 38-year-old woman was mauled by her pet Labrador in May, leaving her with severe facial injuries that her doctors said made it difficult for her to speak and eat. The donor was a brain dead woman. (AP Photo/Francois Mori)
AMIENS, FRANCE - NOVEMBER 21: In this handout image supplied by CHU Amiens, Isabelle Dinoire, 39, poses for a portrait on November 21, 2006 in Amiens, France. The portrait was taken one year on after the surgical operation in which Dinoire was the recipient of the world's first partial face transplant, performed by the combined CHU Amiens and Lyon Hospital team. French surgeons stated that they considered the procedure to have been a success both aesthitically and medically as Dinoire's facial functions continue to improve. (Photo by CHU Amiens via Getty Images)
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While the initial procedure was largely successful, the French woman did struggle with issues involving tissue rejection and the medications prescribed to diminish the risk of such an occurrence.

The drugs put her at a high cancer risk level, and she had reportedly developed two different kinds.

The transplant she underwent over a decade ago was groundbreaking, and in the years since, more than 30 similar procedures have been performed.

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