For Clarkson, who scored an Academy Award nomination for Pieces of April, the role marks her biggest TV role to date since 1996's Murder One. She previously won a pair of Emmys for her guest role in HBO's Six Feet Under. Her credits include Shutter Island, The Green Mile and Friends With Benefits. Clarkson is repped by CAA and Anonymous Content.
See photos of "House of Cards" star, Kevin Spacey:
EXCLUSIVE - Kevin Spacey seen at Netflix 'House of Cards' Academy Screening at AMPAS on Monday, April 27, 2015, in Los Angeles, CA. (Photo by Eric Charbonneau/Invision for Netflix/AP Images)
Kevin Spacey arrives at the 4th Annual Reel Stories, Real Lives Benefit held at Milk Studios on Saturday, April 25, 2015, in Los Angeles (Photo by Richard Shotwell/Invision/AP)
FILE - In a Monday, June 9, 2014 file photo, U.S. actor Kevin Spacey arrives for the European Premiere of Now, at a cinema in central London. A Massachusetts woman, Linda Louise Culkin of Quincy, Mass., who threatened to blow up, torture and castrate Spacey in what prosecutors called a âpersistent and malevolentâ cyberstalking campaign, was sentenced Wednesday, Sept. 17, 2014, to more than four years in prison. A federal judge in Boston also ordered Culkin to pay Spacey $124,000 in restitution for bodyguards.The 55-year-old Culkin has been jailed since January 2012, meaning she has about 18 months left to serve. She pleaded guilty in November to charges including mailing threatening communications, and sending false information regarding explosives. (Photo by Joel Ryan/Invision/AP, File)
Singer Sting, left, and actor Kevin Spacey perform together at the 25th Anniversary Rainforest Fund benefit concert at Carnegie Hall on Thursday, April 17, 2014 in New York. (Photo by Evan Agostini/Invision/AP)
Kevin Spacey poses in the press room with the award for best actor in a television series - drama for âHouse of Cardsâ at the 72nd annual Golden Globe Awards at the Beverly Hilton Hotel on Sunday, Jan. 11, 2015, in Beverly Hills, Calif. (Photo by Jordan Strauss/Invision/AP)
Kevin Spacey arrives at the Oscars on Sunday, March 2, 2014, at the Dolby Theatre in Los Angeles. (Photo by Jordan Strauss/Invision/AP)
Kevin Spacey arrives at a special screening for season 2 of "House of Cards", on Thursday, Feb. 13, 2014 in Los Angeles. (Photo by Jordan Strauss/Invision/AP)
U.S. actor Kevin Spacey is seen during a conference at the Mobile World Congress in Barcelona, Spain, Thursday, Feb. 19, 2009. Some 50,000 industry officials from major cell phone makers, telecom companies and high-technology firms are converging in Barcelona for an annual four-day Mobile World Congress that opened Monday. (AP Photo/Manu Fernandez)
U.S. actor, director and producer Kevin Spacey talks to the Associated Press, about his nomination for an Emmy award for his role in the U.S. television movie 'Recount', in London, Thursday, July 17, 2008. (AP Photo/Sang Tan)
Actor Kevin Spacey poses at the Four Seasons Hotel in Beverly Hills, Calif., Nov. 16, 2004. Spacey both directs and stars in the new biographical film, "Beyond the Sea," about singer and teen idol Bobby Darin. (AP Photo/Ann Johansson)
Kevin Spacey holds up his Oscar for best actor in a leading role in "American Beauty" during the 72nd Academy Awards at the Shrine Auditorium in Los Angeles, Sunday, March 26, 2000. (AP Photo/Kevork Djansezian)
Actor Kevin Spacey waves to the crowd in the Houston Astrodome as he walks to the mound to throw out the ceremonial first pitch of game 4 in the National League Division Series between the Houston Astros and the Atlanta Braves, Saturday, Oct. 9, 1999. (AP Photo/Beth A. Keiser)
Kevin Spacey is all smiles backstage as he holds his Oscar for Best Supporting Actor for "The Usual Suspects" at the 68th Annual Academy Awards March 25, 1996, in Los Angeles. (AP Photo/Damian Dovarganes)
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Scott, meanwhile, will make his TV return following multiple seasons of USA Network's Royal Pains and a guest arc on FX's Sex&Drugs&Rock&Roll. On the film side, his credits include The Amazing Spider-Man 2 and The Exorcism of Emily Rose. He's with Paradigm.
For House of Cards, the castings mark the first additions to the series for new showrunners Frank Pugliese and Melissa James Gibson, who first joined the drama as senior writers in season three. They take over the showrunning duties from creator Beau Willimon, who in January exited the series when it was renewed for a fifth season.