Amy Schumer was met with both boos and cheers during her stand-up show in Tampa, Florida, after she laid into Donald Trump for several minutes, an insider tells ET.
The 35-year-old comedian referred to the presidential hopeful as an "orange, sexual-assaulting, fake-college-starting monster," which audibly displeased some of the audience members. "Of course, we're in Florida, you're going to boo," Schumer said. "I know you're here to laugh, but you choose how you're going to live your life, and it's just too important."
She also invited a man, who she said "doesn't seem like a psychopath," to come onstage and explain why he was voting for Trump. When the audience member explained that he felt the country was in better hands with Trump and that he "can't trust Hillary," some audience members started to cheer. "We're not talking about why you don't like Hillary, we're talking about why you like Trump," Schumer responded. After speaking with him for a bit, she kindly thanked the man for joining her onstage.
An insider at the show tells ET that Schumer's comments on Trump led to some of the audience members walking out mid-show. "It got a little awkward when she got political and someone shouted, 'We came to laugh,'" the insider says. "People definitely left. It went on longer than it should have, especially since she was only out there for little over an hour."
Schumer also addressed recent sexual assault allegations against Trump, which she said were "really triggering" for her. Another insider at the stand-up show tells ET that Schumer -- who revealed in her book, The Girl With the Lower Back Tattoo, that she was a victim of sexual assault -- then asked those in the audience who were survivors of sexual assault to stand up and dozens rose from their seats.
Amy Schumer through her career
Amy Schumer through her career
SANTA MONICA, CA - JANUARY 17: Actress-writer Amy Schumer accepts Critics' Choice MVP Award onstage during the 21st Annual Critics' Choice Awards at Barker Hangar on January 17, 2016 in Santa Monica, California. (Photo by Kevin Winter/Getty Images)
BEVERLY HILLS, CA - JANUARY 10: In this handout photo provided by NBCUniversal, Presenters Amy Schumer and Jennifer Lawrence speak onstage during the 73rd Annual Golden Globe Awards at The Beverly Hilton Hotel on January 10, 2016 in Beverly Hills, California. (Photo by Paul Drinkwater/NBCUniversal via Getty Images)
BEVERLY HILLS, CA - JANUARY 10: Amy Schumer arrives at the 73rd Annual Golden Globe Awards at The Beverly Hilton Hotel on January 10, 2016 in Beverly Hills, California. (Photo by Steve Granitz/WireImage)
WATCH WHAT HAPPENS LIVE -- Pictured: Amy Schumer -- (Photo by: Charles Sykes/Bravo/NBCU Photo Bank via Getty Images)
Comic Amy Schumer arrives at Wilhelmina Models' 40th anniversary celebration at The Angel Orensanz Foundation Thursday, Nov. 29, 2007 New York. (AP Photo/Gary He)
Amy Schumer performs at the "Just For Laughs Comedy Festival" on Wednesday June 13, 2012 in Chicago. (Photo by Barry Brecheisen/Invision/AP)
Amy Schumer attends the Comedy Central Roast of Roseanne at the Hollywood Palladium on Saturday, Aug. 4, 2012, in Los Angeles. (Photo by Jordan Strauss/Invision/AP)
Comedian Amy Schumer performs at Glamour's presentation of 'These Girls' at Joe's Pub on May 20, 2013 in New York City. (Photo by Astrid Stawiarz/Getty Images for Glamour)
Comedian Amy Schumer performs on stage at 'Comedy Central's Stars Under the Stars' at Central Park SummerStage on June 26, 2013 in New York City. (Photo by Neilson Barnard/Getty Images for Comedy Central)
Comedian Amy Schumer attends the 'Anchorman 2: The Legend Continues' premiere, sponsored by Buffalo David Bitton, on December 15, 2013 in New York City. (Photo by Cindy Ord/Getty Images for Buffalo David Bitton)
Comedian Amy Schumer attends the 'Girls' season three premiere at Jazz at Lincoln Center on January 6, 2014 in New York City. (Photo by Andrew H. Walker/Getty Images)
Honoree Amy Schumer accepts the Breakthrough Award for Comedy onstage at the Variety Breakthrough of the Year Awards during the 2014 International CES at The Las Vegas Hotel & Casino on January 9, 2014 in Las Vegas, Nevada. (Photo by Jeff Bottari/Getty Images for Variety)
Comedian Amy Schumer speaks onstage at NRDC's 'Night Of Comedy' benefiting the Natural Resources Defense Council at 583 Park Ave on November 5, 2014 in New York City. (Photo by Bryan Bedder/Getty Images for NRDC)
Actress/comedian Amy Schumer poses for a photo at the book signing for her book 'Not That Kind of Girl: A Young Woman Tells You What She's 'Learned' at Barnes & Noble Union Square on September 30, 2014 in New York City. (Photo by J. Countess/Getty Images)
Amy Schumer attends the Glamour 2014 Women Of The Year Awards at Carnegie Hall on November 10, 2014 in New York City. (Photo by Dimitrios Kambouris/Getty Images for Glamour)
Comedian Amy Schumer attends GQ and LeBron James Celebrate All-Star Style on February 14, 2015 in New York City. (Photo by Jamie McCarthy/Getty Images for GQ)
Comedian Amy Schumer arrives for the GQ Men of the Year Party, at Chateau Marmont in West Hollywood, California, on December 4, 2014. (Photo by Robyn Beck/AFP/Getty Images)
Amy Schumer attends Comedy Central Night Of Too Many Starts at Beacon Theatre on February 28, 2015 in New York City. (Photo by Stephen Lovekin/Getty Images for Comedy Central)
Amy Schumer performs onstage at Comedy Central Night Of Too Many Stars at Beacon Theatre on February 28, 2015 in New York City. (Photo by Mike Coppola/Getty Images for Comedy Central)
Actress Amy Schumer (L) and producer Kim Caramele arrive at the screening of 'Trainwreck' during the 2015 SXSW Music, Film + Interactive Festival at the Paramount on March 15, 2015 in Austin, Texas. (Photo by Michael Buckner/Getty Images)
Host Amy Schumer attends The 2015 MTV Movie Awards at Nokia Theatre L.A. Live on April 12, 2015 in Los Angeles, California. (Photo by Rich Polk/Getty Images for MTV)
Amy Schumer poses for a photo in the press room during the 2015 MTV Movie Awards on April 12, 2015 in Los Angeles, California. (Photo by Frederic J. Brown/AFP/Getty Images)
Actress Amy Schumer speaks at Tribeca Talks: After the Movie: Inside Amy Schumer during the 2015 Tribeca Film Festival at Spring Studio on April 19, 2015 in New York City. (Photo by Robin Marchant/Getty Images for the 2015 Tribeca Film Festival)
Honoree and Comedian Amy Schumer pretends to trip and fall on the floor in front of honorees Kim Kardashian (2nd-L) and Kanye West (L) as they attend the Time 100 Gala celebrating the Time 100 issue of the Most Influential People at The World at Jazz at Lincoln Center on April 21, 2015 in New York.(Photo by Timothy A. Clary/AFP/Getty Images)
Comedian Amy Schumer speaks onstage at Universal Pictures Invites You to an Exclusive Product Presentation Highlighting its Summer of 2015 and Beyondat The Colosseum at Caesars Palace during CinemaCon, the official convention of the National Association of Theatre Owners, on April 23, 2015 in Las Vegas, Nevada. (Photo by Michael Buckner/Getty Images for CinemaCon)
Actress Amy Schumer accepts the 'CinemaCon Breakthrough Performer of the Year Award' onstage at The CinemaCon Big Screen Achievement Awards Brought to you by The Coca-Cola Company at The Colosseum at Caesars Palace during CinemaCon, the official convention of the National Association of Theatre Owners, on April 23, 2015 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images for CinemaCon)
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Prior to the show, the Inside Amy Schumer star also registered people to vote while wearing a T-shirt in support of Clinton. "With my brother registering voters in Florida," she Instagrammed. "Registration was extended to the 18th."
Also this weekend, Jamie Lee Curtis revealed what she thinks of Trump, telling ET that he is going to "shock us all into an understanding that people are who they say they are." Here's more of our interview with the Scream Queens star, who also responds to Trump's 2004 comments about her Freaky Friday co-star, Lindsay Lohan.