Reese Witherspoon and Mindy Kaling in talks to join Oprah Winfrey in 'A Wrinkle in Time'

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Reese Witherspoon and Mindy Kaling are in negotiations to appear in Disney's adaptation of the classic novel "A Wrinkle In Time," TheWrap has learned.

The project is being directed by Ava DuVernay.

Oprah Winfrey, who is re-teaming with her "Selma" director, has already been cast in the film to star as Mrs. Which.

The script was written by "Frozen" writer and co-director Jennifer Lee, who won an Oscar in 2014 for the Disney Animation film.

The classic children's book by Madeleine L'Engle revolves around a young girl in search of her missing scientist father. Mrs. Which is one of the supernatural entities who helps the girl — along with her brother and her friend — traverse the universe.

Winfrey had a smaller role in DuVernay's 2014 historical drama "Selma," and also helped the film get made, serving as a producer. The two have also teamed up for DuVernay's forthcoming OWN drama series "Queen Sugar," which premieres Sept. 6.

More to come...

Read original story Reese Witherspoon and Mindy Kaling in Talks to Join Oprah Winfrey in 'A Wrinkle in Time' At TheWrap

Check out more from Reese Witherspoon in the gallery below!

19 PHOTOS
Reese Witherspoon through the years
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Reese Witherspoon through the years
Reese Witherspoon arrives at the Hollywood Film Awards at the Beverly Hilton Hotel on Sunday, Nov. 1, 2015, in Beverly Hills, Calif. (Photo by Jordan Strauss/Invision/AP)
Actress Reese Witherspoon, pictured at the Four Seasons Hotel in Beverly Hills, Calif., June 30, 2001, stars in the comedy movie, "Legally Blonde," which opens nationwide July 13. (AP Photo/Chris Pizzello)
Reese Witherspoon accepts the award for outstanding performance by a female actor in a leading role for her work in "Walk the Line," at the 12th Annual Screen Actors Guild Awards on Sunday, Jan. 29, 2006, in Los Angeles. (AP Photo/Mark J. Terrill)
Actress Reese Witherspoon arrives to the premiere of "Rendition" in Beverly Hills, Calif., Wednesday, Oct. 10, 2007. (AP Photo/Mark J. Terrill)
**FILE**Actress Reese Witherspoon and her husband Ryan Phillippe pose at the Academy Awards March 5, 2006, in Los Angeles. Phillippe wants joint custody of his children with the "Walk the Line" Oscar winner. Witherspoon filed for divorce on Nov. 8, citing "irreconcilable differences" as the reason for the split, and she asked for physical custody of the couple's two children. In a response filed Tuesday, MaY 15, 2007, Phillippe also cited irreconcilable differences but asked for joint legal custody and physical custody of the children as well as visitation granted "to both parties, equally allocated." (AP Photo/Kevork Djansezian)
Reese Witherspoon arrives at the premiere of the film "Four Christmases" in Los Angeles, Friday, Nov. 20, 2008. (AP Photo/Chris Pizzello)
U.S. actress Reese Witherspoon, right, and British-born Canadian actor Kiefer Sutherland, left, are seen during a photocall for the animation movie 'Monsters vs Aliens' in Berlin, Germany, Tuesday March 10, 2009. (AP Photo/Michael Sohn)
Reese Witherspoon, a cast member in "How Do You Know," poses at the premiere of the film in Los Angeles, Monday, Dec. 13, 2010. (AP Photo/Chris Pizzello)
Actors Robert Pattinson and Reese Witherspoon attend the premiere of "Water For Elephants" at The Ziegfeld Theater, in New York, on Sunday, April 17, 2011. (AP Photo/Peter Kramer)
Actress Reese Witherspoon arrives at the 18th Annual ELLE Women in Hollywood celebration in Beverly Hills, Calif., Monday, Oct. 17, 2011. The dinner celebrates womenâs achievements in film. (AP Photo/Matt Sayles)
Reese Witherspoon arrives at the 69th Annual Golden Globe Awards Sunday, Jan. 15, 2012, in Los Angeles. (AP Photo/Matt Sayles)
From left, actors Reese Witherspoon, Matthew McConaughey, and Tye Sheridan depart after a screening of Mud at the 65th international film festival, in Cannes, southern France, Saturday, May 26, 2012. (AP Photo/Francois Mori)
FILE - In this Friday, March 8, 2013 file photo, actress Reese Witherspoon and her husband, Jim Toth, watch the Toronto Raptors take on the Los Angeles Lakers in an NBA basketball game in Los Angeles. Police in Georgia say that Witherspoon has been arrested on a disorderly conduct charge after a traffic stop involving her husband in Atlanta. A Georgia State Police incident report says that Witherspoon was arrested early Friday, April 19, 2013, and charged with disorderly conduct. The report says a state trooper observed that a car driven by Toth was failing to stay in its lane. The officer writes that Witherspoon disobeyed multiple orders to stay in the car while he performed a field sobriety test on Toth. After she refused to return to the car, she was handcuffed and arrested. (AP Photo/Reed Saxon, File)
Actress Reese Witherspoon arrives at the ELLE 20th annual "Women in Hollywood" event at the Four Seasons Hotel on Monday, Oct. 21, 2013 in Los Angeles. (Photo by Jordan Strauss/Invision/AP)
Reese Witherspoon arrives at the Los Angeles premiere of "Inherent Vice" at the TCL Chinese Theatre on Wednesday, Dec. 10, 2014. (Photo by Jordan Strauss/Invision/AP)
Reese Witherspoon arrives at the 72nd annual Golden Globe Awards at the Beverly Hilton Hotel on Sunday, Jan. 11, 2015, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP)
Actress Reese Witherspoon, left, and entertainer Carol Burnett speak at the Wal-Mart shareholder meeting in Fayetteville, Ark., Friday, June 5, 2015. (AP Photo/Danny Johnston)
Reese Witherspoon accepts her award at the 29th American Cinematheque Awards at the Hyatt Regency Century Plaza on Friday, Oct. 30, 2015, in Los Angeles. (Photo by John Salangsang/Invision/AP)
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