"Ghostbusters" came in at second place during its first weekend in theaters, grossing an estimated $46 million from 3,963 screens.
Grosses for Sony and Village Roadshow's horror-comedy reboot are right in line with expectations.
Universal and Illumination Entertainment's "The Secret Life of Pets" won the box office in its second weekend in a row with $50.6 million from 4,381 locations — shy of initial predictions of $55 million.
It received generally favorable reviews, with a current Rotten Tomatoes score of 73 percent, but a weighted Metacritic score of only 60. "Ghostbusters" also has a B+ Cinemascore, reflecting audience anticipation levels among those surveyed.
SEE ALSO: The all-female Ghostbusters cast
The all-female Ghostbusters cast
The all-female Ghostbusters cast
FILE - In this Jan. 11, 2015 file photo, presenter Kristen Wiig poses in the press room at the 72nd annual Golden Globe Awards in Beverly Hills, Calif. Wiig will join Melissa McCarthy, Kate McKinnon and Leslie Jones in an all-female reboot of "Ghostbusters," scheduled for release in July of 2016. Director Paul Feig announced his stars by tweeting their pictures on Twitter on Tuesday, Jan. 27. (Photo by Jordan Strauss/Invision/AP, File)
BOSTON, MA - JUNE 18: Kristen Wiig is seen on the set of 'Ghostbuster' in Boston on June 18, 2015 in Boston, Massachusetts. (Photo by Stickman/Bauer-Griffin/GC Images)
SANTA MONICA, CA - FEBRUARY 21: Actress Kristen Wiig speaks onstage during the 2015 Film Independent Spirit Awards at Santa Monica Beach on February 21, 2015 in Santa Monica, California. (Photo by Kevork Djansezian/Getty Images)
Melissa McCarthy arrives at the People's Choice Awards at the Nokia Theatre on Wednesday, Jan. 7, 2015, in Los Angeles. (Photo by Jordan Strauss/Invision/AP)
US actress Melissa McCarthy poses for photographs on the carpet as she arrives to attend the European premiere of the film 'Spy' in London on May 21, 2015. AFP PHOTO / NIKLAS HALLE'N (Photo credit should read NIKLAS HALLE'N/AFP/Getty Images)
NEW YORK, NY - JUNE 01: Actress Melissa McCarthy speaks during SiriusXM's 'Town Hall' With Melissa McCarthy, Jason Statham And Paul Feig at the SiriusXM Studios on June 1, 2015 in New York City. (Photo by Astrid Stawiarz/Getty Images for SiriusXM)
FILE - In this Sept. 6, 2014 file photo, actress Leslie Jones poses at the "Top Five" premiere at the Princess of Wales Theatre during the 2014 Toronto International Film Festival in Toronto. Jones will star with Melissa McCarthy, Kristen Wiig, and Kate McKinnon in an all-female reboot of "Ghostbusters," scheduled for release in July of 2016. Director Paul Feig announced his stars by tweeting their pictures on Twitter on Tuesday, Jan. 27. (Photo by Arthur Mola/Invision/AP, File)
NEW YORK, NY - FEBRUARY 23: Samantha Yanks, Cecily Strong, Leslie Jones and Debra Halpert attend the Gotham & Hamptons Magazines celebration of Gotham's Spring Issue featuring Saturday Night Live's Cover Stars at Four Seasons Hotel on February 23, 2015 in New York City. (Photo by Eugene Gologursky/Getty Images for Gotham Magazine)
LATE NIGHT WITH SETH MEYERS -- Episode 205 -- Pictured: Leslie Jones, SNL cast member, during an interview on May 12, 2015 -- (Photo by: Lloyd Bishop/NBC/NBCU Photo Bank via Getty Images)
FILE - This Aug. 25, 2014 file photo shows actress Kate McKinnon at the 66th Annual Primetime Emmy Awards at the Nokia Theatre L.A. Live in Los Angeles. McKinnon will star with Melissa McCarthy, Kristen Wiig, and Leslie Jones in an all-female reboot of "Ghostbusters," scheduled for release in July of 2016. Director Paul Feig announced his stars by tweeting their pictures on Twitter on Tuesday, Jan. 27. (Photo by Richard Shotwell/Invision/AP, File)
NEW YORK, NY - APRIL 15: Actress Kate McKinnon attends Opening Night: Live From New York! during the 2015 Tribeca Film Festival at the Beacon Theatre on April 15, 2015 in New York City. (Photo by Jamie McCarthy/Getty Images for the 2015 Tribeca Film Festival)
Kate McKinnon attends the "Anchorman 2: The Legend Continues" premiere on Sunday, Dec. 15, 2013 in New York. (Photo by Charles Sykes/Invision/AP)
Kate McKinnon of NBC's "Saturday Night Live" arrives at the 2013 NBCUniversal Summer Press Day at The Langham Huntington Hotel and Spa on Monday, April 22, 2013 in Pasadena, Calif. (Photo by Jordan Strauss/Invision/AP)
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Meanwhile, Broad Green's drug cartel drama "The Infiltrator" made $6.7 million during its five-day opening — $5.3 million of that during the three-day weekend. In theaters since Wednesday, the fact-based film stars Oscar winner Bryan Cranston and played on 1,601 screens.
The film has an A- Cinemascore with mixed review averages: 65 percent Rotten Tomatoes and a favorable 66 Metascore.