Cancer treatment untested in many patients with immune problems

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(Reuters Health) - - The safety and effectiveness of a new cancer treatment known as immunotherapy is largely unknown in patients with autoimmune diseases, researchers say - and that might account for up to a quarter of individuals with lung cancer.

In autoimmune diseases - such as rheumatoid arthritis, ulcerative colitis or psoriasis, for example - the immune system attacks the body.

Patients with autoimmune diseases have been mostly excluded from clinical trials testing immunotherapies over fears that the treatments will worsen the conditions or cause new ones to appear, because immunotherapy uses the body's own immune system to fight cancer.

As a result, the effectiveness and potential side effects of immunotherapy are largely unknown for these patients, said senior author Dr. David Gerber, of the University of Texas Southwestern Medical Center in Dallas.

To estimate how many people with lung cancer in the U.S. may have autoimmune conditions, the researchers matched government insurance data from 1991 to 2011 with national cancer data from 1992 to 2009.

Overall, there were 210,509 patients with lung cancer, of whom 28,453, or about 14 percent, had been hospitalized at least once for an autoimmune disease or had at least two insurance claims for autoimmune conditions.

Related: Common foods thought to cause cancer:

17 PHOTOS
Common foods suspected of causing cancer
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Cancer treatment untested in many patients with immune problems

Microwave popcorn

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Soda

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Non-organic fruit

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Processed meats

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Alcohol

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Farmed salmon

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Refined sugars

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Canned tomatoes 

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Potato chips

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Hydrogenated oils

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Artificial sweeteners

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Foods that are highly salted, pickled, or smoked

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Red meat

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Highly processed white flours

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"Diet" or "Low Fat" anything

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Genetically modified organisms (GMO's)

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Using more liberal criteria - just one insurance claim for an autoimmune condition - the proportion with one of these diseases went up to nearly 25 percent.

Gerber said doctors can generally speculate about the possible effects immunotherapy will have among people with autoimmune diseases since it's largely untested in that group.

"It's because immunotherapy has demonstrated such effectiveness and promise that these questions are worth asking," he said.

"I don't think the concern is that effectiveness of treatment against the cancer is going to be less," Gerber said. "I think the concern is that toxicity would be more."

There may, however, be concern over the effectiveness of immunotherapy if the person is also on drugs that suppress the immune system, Gerber said.

The results were presented Saturday at the annual meeting of the American Society of Clinical Oncology in Chicago and published online in JAMA Oncology.

SOURCE: JAMA Oncology, online June 4, 2016.

Related: Warning signs and risk factors for breast cancer:

12 PHOTOS
Warning signs and risk factors of breast cancer
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Cancer treatment untested in many patients with immune problems

Risk factors of breast cancer: obesity

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Risk factors of breast cancer: lack of exercise

(Photo by Martin Barraud, Getty Images)

Risk factors of breast cancer: alcohol use

(Photo via Ron Chapple Stock, Getty Images)

Risk factors of breast cancer: an unhealthy diet

(Photo by Dean Belcher, Getty Images)

Risk factors of breast cancer: smoking

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Common signs of breast cancer: a breast mass that is hard and/or irregular 

(Photo via Getty Images)

Common signs of breast cancer: changes in the skin of the breast such as puckering, irritation, scaling, dimpling, redness or thickening

(Photo via Getty Images)

Common signs of breast cancer: swelling of all or part of the breast, even with no specific lump

(Photo via Getty Images)

Common signs of breast cancer: enlargement or swelling of the lymph nodes in the armpit area

(Photo via Getty Images)

Common signs of breast cancer: nipple discharge, that is not breast milk

(Photo via Ron Chapple Stock, Getty Images)

Common signs of breast cancer: nipple retraction, which looks like a turning inward of the nipple

(Photo via Getty Images)

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