Rosie O'Donnell on Donald Trump: 'Do not give up, he will never be president'

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Rosie O'Donnell, patient-zero in Donald Trump's public feuds, couldn't resist taking a swing at the presumptive Republican presidential nominee on Monday night.

At a SAG panel with fellow actresses June Squibb and Linda Lavin, O'Donnell was explaining her role as Allison Janney's ex-lover on the CBS comedy "Mom," when she appeared to slip in a Trump insult.

"I've admired [Allison Janney] for so long, " O'Donnell said. "Being a lesbian in real life — news flash — get off your Twitter sir — don't tell people. ... It is not about politics it is about acting — lots of women around that house, too — I'm not going near him, trust me — Orange man. Anyway, the thing is, fin, his mouth looks like an anus. What I'm trying to say about 'Mom' is that everyone was really warm and lovely. But being that I am gay, I didn't want to be pushing the kiss part."

See photos of Rosie O'Donnell through the years:

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Rosie O'Donnell through the years
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Rosie O'Donnell on Donald Trump: 'Do not give up, he will never be president'
NEW YORK, NY - MAY 17: Rosie O'Donnell attends the 5th Annual Rosie's Theater Kids Spring Benefit at The Alvin Ailey Citigroup Theater on May 17, 2015 in New York City. (Photo by Paul Zimmerman/WireImage)
BENTONVILLE, AR - MAY 07: Rosie O'Donnell attends the 'League of their own' event at Arvest Park hosted by Geena Davis and Rosie O'Donnell at the Bentonville Film Festival on May 7, 2015 in Bentonville, Arkansas. (Photo by Ernesto Di Stefano Photography/WireImage)
NEW YORK, NY - MAY 03: Kate Mulgrew and Rosie O'Donnell attend 'An Evening with Kate Mulgrew', a reading and Q & A about her memoir 'Born with Teeth' at the Vineyard Theatre on May 3, 2015 in New York City. (Photo by Walter McBride/Getty Images)
Uzo Aduba and Rosie O'Donnell attend Netflix's "Orange Is The New Black" Season 2 premiere at the Ziegfeld Theatre on Thursday, May 15, 2014, in New York. (Photo by Scott Roth/Invision/AP)
NEW YORK, NY - FEBRUARY 09: (L-R) Liz McCartney, Rosie O'Donnell and Sarah Uriarte Berry attend the 'Taboo:Ten Years Later' reunion concert at 54 Below on February 9, 2014 in New York City. (Photo by Bruce Glikas/FilmMagic)
NEW YORK, NY - FEBRUARY 06: (L-R) Lena Hall, Rosie O'Donnell and Annaleigh Ashford pose backstage at the hit musical 'Kinky Boots' on Broadway at The Hirshfeld Theater on February 6, 2014 in New York City. (Photo by Bruce Glikas/FilmMagic)
NEW YORK, NY - JANUARY 31: Cyndi Lauper and Rosie O'Donnell attend 'Howard Stern's Birthday Bash' presented by SiriusXM, produced by Howard Stern Productions at Hammerstein Ballroom on January 31, 2014 in New York City. (Photo by Kevin Mazur/Getty Images for SiriusXM)
THE VIEW - Rosie O'Donnell returns to THE VIEW to a standing ovation, FRIDAY, FEB. 7 (11:00 a.m. - 12:00 noon, ET) airing on the ABC Television Network. Never shy on opinions, the Emmy Award-winner joins the co-hosts for Hot Topics, shares how her life dramatically changed since leaving THE VIEW and makes a declaration that even she thought she would never say. The appearance marks the first time Rosie O'Donnell has returned to the talk show since moderating Season 10 (2006-2007). (Photo by Lou Rocco/ABC via Getty Images) BARBARA WALTERS, ROSIE O'DONNELL
NEW YORK, NY - FEBRUARY 06: (L-R) Rosie O'Donnell, Billy Porter as 'Lola', Eric Stonestreet and Andy Kelso as 'Charlie' pose backstage at the hit musical 'Kinky Boots' on Broadway at The Hirshfeld Theater on February 6, 2014 in New York City. (Photo by Bruce Glikas/FilmMagic)
NEW YORK, NY - JANUARY 31: Rosie O'Donnell at SiriusXM's 'Howard Stern Birthday Bash' at Hammerstein Ballroom on January 31, 2014 in New York City. (Photo by Bobby Bank/WireImage)
Actress Jenny McCarthy, right, jokes with Rosie O'Donnell after a radio interview on radio row at the Super Bowl XLVI media center Friday, Feb. 3, 2012, in Indianapolis. The New England Patriots will face the New York Giants in Super Bowl XLVI on Feb. 5. (AP Photo/David J. Phillip)
Television personality Rosie O'Donnell and girlfriend Michelle Rounds attend the National Board of Review awards gala at Cipriani 42nd Street on Tuesday, Jan. 10, 2012 in New York. (AP Photo/Evan Agostini)
Rosie O'Donnell talks to the audience during a taping of her show in Chicago, Thursday, Oct. 6, 2011. "The Rosie Show" premieres Monday, Oct. 10 on the Oprah Winfrey Network (OWN) and will be taped at the former home of "The Oprah Winfrey Show." (AP Photo/Nam Y. Huh)
** FILE ** In this Nov. 13, 2008 file photo, Rosie O'Donnell and her son Parker arrive to the Broadway opening of Billy Elliot The Musical, in New York. O'Donnell's variety special, "Rosie Live," will air Wednesday, Nov. 26, on NBC at 8 p.m. EST. (AP Photo/Stuart Ramson, file)
Rosie O'Donnell arrives at the opening reception for her art exhibition "Solace" at The Gallery at New World Stages Tuesday, Oct. 9, 2007 in New York. (AP Photo/Gary He)
Rosie O'Donnell performs during the True Colors Tour concert at the Greek Theatre in Los Angeles on Saturday, June 30, 2007. (AP Photo/Matt Sayles)
Rosie O'Donnell, second from right, poses with soldiers prior to the official dedication of the Center for the Intrepid, a $50 million high-tech rehabilitation center designed to serve the growing number of soldiers who return from war as amputees or with severe burns, at Fort Sam Houston in San Antonio, Monday, Jan. 29, 2007. (AP Photo/Eric Gay)
Rosie O'Donnell, left, fills the moderator spot as she joins co-hosts Barbara Walters, second from left, Joy Behar, second from right, and Elisabeth Hasselbeck during the taping of the first show of the 10th season of the ABC talk show, "The View," Tuesday, Sept. 5, 2006 in New York. The show began its 10th season with O'Donnell joining the returning Behar, Hasselbeck and Walters. Another change was a cozy, blue-and-orange arena-like set with a glass-top version of the drop-leaf table the ladies sit around for their "Hot Topics" segment. (AP Photo/Mary Altaffer)
Rosie O'Donnell gestures as she enters Manhattan state Supreme Court, Thursday, Nov. 6, 2003, in New York, where the popular TV personality and "Rosie" publisher Gruner + Jahr USA are suing each other for breach of contract. O'Donnell quit the magazine in mid-September 2002, following a dispute over editorial control, and it ceased publication shortly afterward. (AP Photo/Kathy Willens)
Rosie O'Donnell hosts Nickelodeon's 15th annual Kids' Choice Awards in Santa Monica, Calif., Saturday, April 20, 2002. (AP Photo/Lucy Nicholson)
Rosie O'Donnell appeares at the Gladstone Center for girls in Miami, Wednesday, July 26, 2000, during a presentation of a $ 1 million donation from Office Depot to the CHARLEE Program, a south Florida charitable organization that cares for children who have been abused or neglected. (AP Photo/Ed Cox)
Rosie O' Donnell, left, talks to parents about improving day care Tuesday, June 6, 2000, as Democratic presidential candidate Vice President Al Gore and his wife Tipper Gore listen at the Children's All Day School in New York. Gore, who is trying to soften his image and improve his support among women, announced today that he would propose to provide about $8 billion in incentives over the next decade to states that come up with plans to improve both quality and affordability of day care. (AP Photo/Mitsu Yasukawa, Pool)
Rosie O'Donnell, left, poses with Barbra Streisand during the taping of the Rosie O'Donnell Show in New York Wednesday, Nov. 19, 1997. The show will air Friday Nov. 21, 1997. (AP Photo/Warner Bros., Rav Amati)
Comedian-actress Rosie O'Donnell is shown in this 1994 photo. (AP Photo)
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The comedian's comment was the latest in a back-and-forth with Trump dating to 2006, when O'Donnell first blasted the billionaire on "The View." The feud has persisted for a decade, and came up last summer at the Republican debate. Just days ago, Trump said of O'Donnell, "Who the hell wouldn't speak badly about Rosie O'Donnell? She's terrible. She's terrible."

Speaking to Variety, O'Donnell seemed to assure fans she's not putting the tabloid-war to rest anytime soon and will continue to rail against Trump, which she has done actively on Twitter. "I believe in the innate humanity and sensible nature of Americans," O'Donnell said. "Do not give up, he will never be president."

See photos of Donald Trump's recent "TODAY" Show appearance:

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Donald Trump on TODAY Show
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Rosie O'Donnell on Donald Trump: 'Do not give up, he will never be president'
U.S. Republican presidential candidate Donald Trump (C) poses with members of his family during an appearance on NBC's "Today" show in New York, April 21, 2016. REUTERS/Brendan McDermid
U.S. Republican presidential candidate Donald Trump holds a town hall meeting with hosts Matt Lauer and Savannah Guthrie on NBC's "Today" show in New York, April 21, 2016. REUTERS/Brendan McDermid
U.S. Republican presidential candidate Donald Trump arrives for a town hall meeting on NBC's "Today" show in New York, April 21, 2016. REUTERS/Brendan McDermid
U.S. Republican presidential candidate Donald Trump reacts to an answer his wife Melania gives during an interview on NBC's "Today" show in New York, April 21, 2016. REUTERS/Brendan McDermid TPX IMAGES OF THE DAY
U.S. Republican presidential candidate Donald Trump speaks during an interview with hosts Matt Lauer and Savannah Guthrie on NBC's "Today" show in New York, April 21, 2016. REUTERS/Brendan McDermid
NEW YORK, NY - APRIL 21: Presidential Candidate Donald Trump attends NBC's 'Today' Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by John Lamparski/WireImage)
NEW YORK, NY - APRIL 21: Presidential Candidate Donald Trump attends NBC's 'Today' Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by John Lamparski/WireImage)
Eric Trump, Ivanka Trump and Donald Trump Jr. Trump attend NBC's 'Today' Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by John Lamparski/WireImage)
Donald Trump lll attends NBC's 'Today' Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by John Lamparski/WireImage)
NEW YORK, NY - APRIL 21: 2016 Republican presidential candidate Donald Trump (L) signs autographs during NBC's Today Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by D Dipasupil/FilmMagic)
NEW YORK, NY - APRIL 21: 2016 Republican presidential candidate Donald Trump attends NBC's Today Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by D Dipasupil/FilmMagic)
NEW YORK, NY - APRIL 21: Melania and Presidential Candidate Donald Trump attends NBC's 'Today' Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by John Lamparski/WireImage)
NEW YORK, NY - APRIL 21: (L-R) Tiffany Trump, Donald Trump Jr, Kai Trump, Melania Trump, 2016 Republican presidential candidate Donald Trump, Tristan Trump, Ivanka Trump, and Eric Trump pose onstage during NBC's Today Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by D Dipasupil/FilmMagic)
NEW YORK, NY - APRIL 21: Presidential Candidate Donald Trump, Matt Lauer and Savannah Guthrie attend NBC's 'Today' Trump Town Hall at Rockefeller Plaza on April 21, 2016 in New York City. (Photo by John Lamparski/WireImage)
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