Air strikes hit Aleppo hospital, at least 27 killed: Observatory

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Hospitals in Syria Hit by Airstrikes

Air strikes hit a hospital in a rebel-held area of Syria's Aleppo and killed at least 27 people, including three children and the city's last pediatrician, the Syrian Observatory for Human Rights said on Thursday.

The al-Quds hospital was supported by international medical charity Medecins Sans Frontieres (MSF), which said it was destroyed after being hit by a direct air strike that killed at least three doctors.

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The head of a rescue service put the death toll at 50, saying most of the dead were in a building next door.

Aleppo has been the epicenter of a military escalation that has helped to undermine U.N.-led peace talks in recent weeks. A cessation of hostilities agreement has unraveled and fighting has resumed on numerous fronts in western Syria.

The city is divided into areas held by the government and rebels.

The Britain-based Observatory said 91 civilians had been killed in air strikes in the past six days in Aleppo and 49 civilians were killed in rebel shelling of government-held areas.

"Destroyed #MSF-supported hospital in Aleppo was well known locally and hit by direct airstrike on Wednesday. Hospitals are #notatarget," an MSF Twitter account said.

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Air strikes hit Aleppo hospital, at least 27 killed: Observatory
In this Thursday, Sept. 10, 2015 photo, Syrian refugee boys herd sheep near a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
In this Friday, Sept. 11, 2015 photo, Syrians line up to apply for visas, outside the German embassy, in Rabieh, north Beirut, Lebanon. Many of those applying are seeking asylum -- a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Friday, Sept. 11, 2015 photo, Syrians line up to apply for visas, outside the German embassy, in Rabieh, north Beirut, Lebanon. Many of those applying are seeking asylum -- a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Friday, Sept. 11, 2015 photo, Syrian Abdul-Razzak al-Dabi, 40, who wants to move to Germany where he can treat his two disabled sons, displays medical reports, as he waits with other Syrians who are lining up to apply for visas, outside the German embassy, in Rabieh north of Beirut, Lebanon. Many of those applying for visas are seeking asylum -- a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Friday, Sept. 11, 2015, photo, a Syrian boy sits in a wheelchair as he lines up with his family to apply for an asylum visa, outside the German embassy, in Rabieh, north Beirut, Lebanon. Many of those applying are seeking asylum -- a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Friday, Sept. 11, 2015 photo, a Syrian man, right, Andreh Abdul-Nour, 19, who lost his right leg in a mortar attack in the northern city of Aleppo last December, waits with other Syrians, who line up to apply for visas, outside the German embassy, in Rabieh, north Beirut, Lebanon. Many of those applying are seeking asylum -- a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Thursday, Sept. 10, 2015 photo, Syrian refugee Rim Obeid, 26, hangs laundry at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
n this Friday, Sept. 11, 2015 photo, a Lebanese policeman stands guard as Syrian citizens line up to apply for visas, outside the German embassy, in Rabieh, north Beirut, Lebanon. Many of those applying are seeking asylum - a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Thursday, Sept. 10, 2015 photo, Syrian refugee Rim Hilal, 25, reacts during an interview with The Associated Press inside her tent at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
In this Thursday, Sept. 10, 2015 photo, Syrian refugee Mohammed Adnan, speaks during an interview with The Associated Press inside his tent at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
In this Thursday, Sept. 10, 2015, a Syrian refugee covered with a cloth sleeps inside his family's tent, at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
In this Thursday, Sept. 10, 2015 photo, Syrian refugee boys watch television inside their family's tent at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
In this Thursday, Sept. 10, 2015 photo, Syrian refugee Ibrahim Mahmoud speaks during an interview with The Associated Press surrounded by his children inside his tent at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. AP Photo/Bilal Hussein)
In this Thursday, Sept. 10, 2015 photo, Syrian refugee Abdelkrim Mahmoud sleeps on a hammock hung in a tent at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The unending misery of the around 4 million Syrian refugees scattered around Turkey, Lebanon, Jordan and other Arab nations is one significant factor in the rise of those willing to risk the dangerous sea crossing and exhausting land trek to Europe. With the Syrian civil war in its fifth year, they have little hope of returning home, and for many the situation in exile is worsening. (AP Photo/Bilal Hussein)
In this Friday, Sept. 11, 2015 photo, Syrian citizens line up to apply for visas, outside the German embassy, in Rabieh north Beirut, Lebanon. Many of those applying are seeking asylum -- a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Friday, Sept. 11, 2015 photo, a Syrian man holds his family's passports as he lines up with other Syrians to apply for asylum visas, outside the German embassy, in Rabieh, north Beirut, Lebanon. Many of those applying are seeking asylum - a process that could take months. Lebanon hosts more than 1.1 million Syrian refugees or a quarter of the country's entire population while Jordan hosts about 630,000 Syrian refugees, who now make up about 10 percent of the country's population. (AP Photo/Hussein Malla)
In this Thursday, Sept. 10, 2015, Syrian refugee Ghazi Helal, 28, right, speaks during an interview with The Associated Press as his wife Rim, 25, and 17-month-old son Mohammed sit next to him inside their tent at a Syrian refugee camp in the town of Deir Zanoun, Bekaa Valley, Lebanon. The Helal family is willing to risk the arduous, dangerous journey to Europe, but, among the poorest of the Syrian refugees across the region, the family can’t afford to pay a smuggler. (AP Photo/Bilal Hussein)
?In this Thursday, Sept. 10, 2015 photo, Amena Abomosa, 43, a single mother, ?shows the documents for her successful application for direct resettlement in France, in Amman, Jordan. The family fled Damascus Syria for Jordan after Abomosa’s husband was killed by a sniper as he tried to save a wounded child. A single mother with three kids supporting a grandmother with cancer, Abomosa is headed to France on Monday, Sept. 15, 2015, a rare recipient of legal migration. Abomosa was able to prove her hardship and need for asylum because she carried with her from Syria a trove of documents detailing her struggle. (AP Photo/Sam McNeil)
?In this Thursday, Sept. 10, 2015 photo, Amena Abomosa, 43, center, poses for a photo with her daughters Isra,18, left, and Reemaz, 17, at their family home in Amman, Jordan. The family fled Damascus, Syria for Jordan after Abomosa’s husband was killed by a sniper while trying to save a wounded child. A single mother with three kids supporting a grandmother with cancer, Abomosa is headed to France on Monday, Sept. 14, 2015, a rare recipient of legal migration papers. (AP Photo/Sam McNeil)
In this Thursday, Sept. 10, 2015 photo, Amena Abomosa, 43, holds the passports of her five-person household containing visas to allow them to resettle as refugees in France,in Amman Jordan. The family fled Damascus, Syria for Jordan after Abomosa’s husband was killed by a sniper while trying to save a wounded child. A single mother with three kids supporting a grandmother with cancer, Abomosa is headed to France on Monday, Sept. 14, 2015, a rare recipient of legal migration. (AP Photo/Sam McNeil)
In this Thursday, Sept. 10, 2015 photo, Amena Abomosa's "widow of a martyr" certificate issued by the Syrian Institution for Documenting and Publishing lays next to two portraits of her 62-year-old mother, Hana, and other documents, in Amman, Jordan. A year after her husband, Abdul Arrzaq Adnan Khalil Mardini, 48, was killed by a sniper in Damascus in July 2012, Abomosa fled Syria for Jordan with her three kids supporting a mother with cancer. On Monday, Sept. 14, 2015, Abomosa is headed to France, a rare recipient of legal migration. ????????????????(AP Photo/Sam McNeil)
In this Monday, Sept. 7, 2015 photo, Syria's top diplomat in Jordan, Ayman Alloush, looks over documents for the passport application of a Syrian refugee outside the Syrian embassy in Amman, Jordan. Criticizing the international and regional failure to address Syrian’s plight within the Middle East, Alloush, said he was directing staff to work overtime to issue the travel documents regardless of the applicant's sect. (AP Photo/Sam McNeil)
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Bebars Mishal of the Civil Defence in Aleppo told Reuters that 40 people had been killed in a five-storey building next to the hospital.

A Syrian military source said government warplanes had not been used in areas where airstrikes were reported.

The Russian defense ministry, which is also conducting air strikes in Syria in support of President Bashar al-Assad, could not immediately be reached for comment. Russia has previously denied hitting civilian targets in Syria.

The Syrian state news agency SANA said nine people had been killed in rebel shelling of residential areas of Aleppo on Thursday.

The Syrian military source said the army has been responding to insurgent attacks in Aleppo, adding: "If the militants continue using this fire and bombardment of civilians, the army will certainly not be quiet about it."

U.N. envoy Staffan de Mistura said on Thursday the cessation of hostilities agreement was "barely alive".

Peace talks he has convened in Geneva were undermined last week when the main opposition alliance walked out, citing ongoing violence and calling for proper implementation of a U.N. resolution requiring full humanitarian access to besieged areas.

The talks were making no obvious progress toward discussion of the political transition sought by President Bashar al-Assad's opponents.

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