Garry Shandling's apparent cause of death was a heart attack

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Garry Shandling Dead at 66

Comedian Garry Shandling's life was cut tragically short on Thursday after The Larry Sanders Show star died of an apparent heart attack. Shandling was 66 at the time of his death.

His publicist Alan Nierob told the ET that Shandling had no history of heart problems, but that doctors believe he died as the result of a heart attack.

SEE MORE: EXCLUSIVE: Goldie Hawn Tears Up Remembering Garry Shandling

There is no autopsy planned at this time as he is believed to have died of natural causes, a coroner told the Associated Press.

Following the news of Shandling's death, co-stars, friends, and fellow comedians spoke out, honoring the trailblazing comedian and writer.

"I'm gonna miss him. It was such a shock," actress Goldie Hawn told ET through tears at UCLA Institute of the Environment and Sustainability on Thursday night.

Stars react to the death of Garry Shandling:

Stars react to Garry Shandling's death
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Garry Shandling's apparent cause of death was a heart attack
RIP the great Garry Shandling. Surely, one of the most influential comedians of a generation.
Goodbye Gary Shandling thank you for your kindness and your generosity and for making me laugh so damn much
One of the funniest of all, the beloved and very complicated Gary Shandling has died.
Sunday, my longtime friend Garry Shandling was here, making every1 laugh. I loved him. I'll miss our talks the most.
Garry Shandling was as kind and generous as he was funny and that is saying a lot.
.@GarryShandling no no no. I love you. I cannot accept that you are gone. Rest in Power my hero. #RIPGarry
Not Garry Shandling!!!!!! A treasure!!!!!! How sad.
LARRY SANDERS FOREVER. Such sad news. #RIPGarryShandling
No!!! Not #GaryShandling!! I am devastated. Grew up with Larry Sanders. Can't process this. RIP. Beyond sad. Thoughts are with his family.
Wait, what? Gary Shandling? No.
I am shocked that Gary Shandling has passed. I was so thrilled to have worked with him on The Larry Sanders Show. So funny & witty. RIP.
Gary Shandling was a comedy hero of mine. He once sent me a thank you note that read, "Thanks for nothing." RIP
Peace to a very funny man Garry Shandling
Sad today. My friend @GarryShandling passed. He encouraged me from the very start. A few weeks ago he told me life was short and enjoy it.
I can't........
Sad to hear about Garry Shandling's death. He made me laugh.
Saddened over Garry Shandling. He was a comedy idol of mine. He leaves behind the greatest single-camera comedy of all time. #LarrySanders
Absolutely can't process the loss of Garry Shandling. Such a genius, such a wonderful man, such an inspiration. I was so honored to know him
Garry Shandling, you came to an early promotional screening of CYRUS and hung w/me & @jayduplass afterwards at PF Changs. Thank you.
"Nice guys finish first. If you don't know that, then you don't know where the finish line is." Garry Shandling
R.I.P. Garry Shandling. I’m so shocked and saddened. He was brilliantly funny, and so kind to me.
The great Garry Shandling's work is such a touchstone for me that I was actually discussing him moments before I heard the sad news. RIP
If it's true I am heartsick @GarryShandling has died? One in a million brilliant people say it's not so
R.I.P. Garry Shandling. I am so saddened to hear this. Brilliantly funny and such a great guy. He will be so missed.
I'm both shocked & saddened at the passing of Garry Shandling. He'll forever remain a comedic legend. #RIP
Can't believe that I just heard Garry Shandling died. I'm shattered.
This Garry Shandling news is devastating.
OMG not @GarryShandling, I'm heartbroken and will always remember our laughs we shared on the set of #XFiles #RIP
So saddened by the death of Garry Shandling. Brilliantly funny guy. And a sweetheart, too. Did his show twice. RIP.
This really hurts. Rest In Peace, @GarryShandling.
RIP Garry Shandling. #Irreplaceable
Heartbreaking news about Garry Shandling. Just heartbreaking.
He was as deep as he was funny. I wanted Garry Shandling to live forever and I somehow thought he would.
Rest in Peace, Garry Shandling. His work, including the Larry Sanders Show, was an enormous influence.
Oh my ..GOD will laugh now as he never has Before REST IN PEACE .. Wayyyy to soon
Nooooo!!! I love Garry Shandling. So sad!! #pioneer
Dammit. He was the best. So sad. RIP Garry Shandling
R.I.P. @GarryShandling. A great career and an iconic television series. #larrysanders :(
Garry Shandling is one of the great teachers in my life. He taught me about subtext, honesty, compassion, the best kind of comedy. Much love
So sad to hear about @GarryShandling he was one of my favorites #ripgarryshandling
Gary Shandling was a comedy hero of mine. He once sent me a thank you note that read, "Thanks for nothing." RIP
Garry Shandling you were and always will be comedy gold. #gonewaytoosoon #rip #alwaysfunny
I'm both shocked & saddened at the passing of Garry Shandling. He'll forever remain a comedic legend. #RIP
#GaryShandling NO!! What happened?!! My first job in LA. NO!
Gary Shandling was to comedy what grumpy cat is to the internet. #gamechanger. RIP #garyshandling.
Oh no RIP @garyshandling Such a talent.

READ MORE: Conan O'Brien Remembers Garry Shandling Who Helped Him in a 'Particularly Difficult Time'

Conan O'Brien remembered Shandling during Thursday's show, recalling how the comedian helped him through a tough time in his life after he was fired from The Tonight Show.

"He was obviously hysterically funny pretty much all the time, but he was also extremely sensitive," O'Brien said. "He was complicated. And he had a ton of empathy for other people, and I want to make that point. That is something in this business, in comedy, that is very rare."

Shandling was best known for his work on The Larry Sanders Show and It's Garry Shandling's Show. The Emmy winner was revered in the comedy world for his work as both a writer and comic.

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